RAGE-independent autoreactive B cell activation in response to chromatin and HMGB1/DNA immune complexes
Avalos AM, Kiefer K, Tian J, Christensen S, Shlomchik M, Coyle AJ, Marshak-Rothstein A. RAGE-independent autoreactive B cell activation in response to chromatin and HMGB1/DNA immune complexes. Autoimmunity 2009, 43: 103-110. PMID: 20014975, PMCID: PMC2929824, DOI: 10.3109/08916930903384591.Peer-Reviewed Original ResearchConceptsAM14 B cellsB cell activationHMGB1-DNA complexHMGB1-RAGE interactionNuclear DNACell activationAutoreactive B cell activationB cell responsesB cellsDNA immune complexesImmune complexesSoluble formRole of HMGB1DNAAutoreactive B cell responsesCell responsesCell debrisCellsCellular debrisExcessive accumulationRAGE-deficient miceSystemic autoimmune diseaseActivationRole of RAGETLR9-dependent mannerDifferential Cytokine Production and Bystander Activation of Autoreactive B Cells in Response to CpG-A and CpG-B Oligonucleotides
Avalos AM, Latz E, Mousseau B, Christensen SR, Shlomchik MJ, Lund F, Marshak-Rothstein A. Differential Cytokine Production and Bystander Activation of Autoreactive B Cells in Response to CpG-A and CpG-B Oligonucleotides. The Journal Of Immunology 2009, 183: 6262-6268. PMID: 19864612, PMCID: PMC3426913, DOI: 10.4049/jimmunol.0901941.Peer-Reviewed Original ResearchMurine B Cell Response to TLR7 Ligands Depends on an IFN-β Feedback Loop
Green NM, Laws A, Kiefer K, Busconi L, Kim YM, Brinkmann MM, Trail EH, Yasuda K, Christensen SR, Shlomchik MJ, Vogel S, Connor JH, Ploegh H, Eilat D, Rifkin IR, van Seventer JM, Marshak-Rothstein A. Murine B Cell Response to TLR7 Ligands Depends on an IFN-β Feedback Loop. The Journal Of Immunology 2009, 183: 1569-1576. PMID: 19587008, PMCID: PMC2929820, DOI: 10.4049/jimmunol.0803899.Peer-Reviewed Original Research