2013
TLR9 Promotes Tolerance by Restricting Survival of Anergic Anti-DNA B Cells, Yet Is Also Required for Their Activation
Nickerson KM, Christensen SR, Cullen JL, Meng W, Prak E, Shlomchik MJ. TLR9 Promotes Tolerance by Restricting Survival of Anergic Anti-DNA B Cells, Yet Is Also Required for Their Activation. The Journal Of Immunology 2013, 190: 1447-1456. PMID: 23296704, PMCID: PMC3563726, DOI: 10.4049/jimmunol.1202115.Peer-Reviewed Original ResearchConceptsAnti-DNA B cellsB cellsBone marrowAbsence of TLR9Autoimmune prone animalsAutoimmune-prone MRLSystemic lupus erythematosusAnergic B cellsB cell compartmentB cell toleranceAb-forming cellsL chain editingB cell life spanFunctional anergyLupus erythematosusTLR9 expressionAutoreactive cellsPeripheral activationExtrafollicular pathwayPeripheral repertoireSystemic autoimmunityMouse modelAnergic cellsTLR9Cell life span
2009
RAGE-independent autoreactive B cell activation in response to chromatin and HMGB1/DNA immune complexes
Avalos AM, Kiefer K, Tian J, Christensen S, Shlomchik M, Coyle AJ, Marshak-Rothstein A. RAGE-independent autoreactive B cell activation in response to chromatin and HMGB1/DNA immune complexes. Autoimmunity 2009, 43: 103-110. PMID: 20014975, PMCID: PMC2929824, DOI: 10.3109/08916930903384591.Peer-Reviewed Original ResearchConceptsAM14 B cellsB cell activationHMGB1-DNA complexHMGB1-RAGE interactionNuclear DNACell activationAutoreactive B cell activationB cell responsesB cellsDNA immune complexesImmune complexesSoluble formRole of HMGB1DNAAutoreactive B cell responsesCell responsesCell debrisCellsCellular debrisExcessive accumulationRAGE-deficient miceSystemic autoimmune diseaseActivationRole of RAGETLR9-dependent mannerDifferential Cytokine Production and Bystander Activation of Autoreactive B Cells in Response to CpG-A and CpG-B Oligonucleotides
Avalos AM, Latz E, Mousseau B, Christensen SR, Shlomchik MJ, Lund F, Marshak-Rothstein A. Differential Cytokine Production and Bystander Activation of Autoreactive B Cells in Response to CpG-A and CpG-B Oligonucleotides. The Journal Of Immunology 2009, 183: 6262-6268. PMID: 19864612, PMCID: PMC3426913, DOI: 10.4049/jimmunol.0901941.Peer-Reviewed Original Research
2006
Toll-like Receptor 7 and TLR9 Dictate Autoantibody Specificity and Have Opposing Inflammatory and Regulatory Roles in a Murine Model of Lupus
Christensen SR, Shupe J, Nickerson K, Kashgarian M, Flavell RA, Shlomchik MJ. Toll-like Receptor 7 and TLR9 Dictate Autoantibody Specificity and Have Opposing Inflammatory and Regulatory Roles in a Murine Model of Lupus. Immunity 2006, 25: 417-428. PMID: 16973389, DOI: 10.1016/j.immuni.2006.07.013.Peer-Reviewed Original ResearchConceptsLupus-prone miceSystemic lupus erythematosusAutoimmune diseasesToll-like receptor 7Toll-like receptor 9Absence of TLR9TLR7-deficient miceDevelopment of lupusPlasmacytoid DCsLupus erythematosusSerum IgGSusceptible miceAutoantibody specificitiesReceptor 7Receptor 9DNA autoantibodiesClinical diseaseIFN-alphaMurine modelLymphocyte activationTLR7TLR9Regulatory roleDiseaseMice
2005
Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus
Christensen SR, Kashgarian M, Alexopoulou L, Flavell RA, Akira S, Shlomchik MJ. Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus. Journal Of Experimental Medicine 2005, 202: 321-331. PMID: 16027240, PMCID: PMC2212997, DOI: 10.1084/jem.20050338.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, AntinuclearAntibody FormationAutoantigensAutoimmunityB-LymphocytesDNADNA-Binding ProteinsHumansImmunity, InnateLupus NephritisMembrane GlycoproteinsMiceMice, KnockoutReceptors, Cell SurfaceRibonucleoproteins, Small NuclearSnRNP Core ProteinsToll-Like Receptor 3Toll-Like Receptor 9Toll-Like ReceptorsConceptsToll-like receptor 9TLR9-deficient miceAutoantibody productionAutoimmune diseasesReceptor 9Clinical autoimmune diseaseDNA-containing antigensSelf-nuclear antigensAnti-DNA autoantibody productionAnti-dsDNA autoantibodiesLupus-prone miceSystemic lupus erythematosusFormation of autoantibodiesSystemic autoimmune diseaseInnate immune activationAutoreactive B cellsLupus erythematosusAutoantibody formationMurine lupusImmune activationImmunologic toleranceAntichromatin autoantibodiesSmith antigenCpG DNAB cells