Vitamin B12 and hepatitis C: Molecular biology and human pathology
Lott W, Takyar S, Tuppen J, Crawford D, Harrison M, Sloots T, Gowans E. Vitamin B12 and hepatitis C: Molecular biology and human pathology. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 4916-4921. PMID: 11296247, PMCID: PMC33138, DOI: 10.1073/pnas.081072798.Peer-Reviewed Original ResearchMeSH KeywordsAntiviral AgentsBase SequenceClassical swine fever virusDose-Response Relationship, DrugEncephalomyocarditis virusHepacivirusHepatitis CHumansLiverMolecular Sequence DataProtein BindingProtein BiosynthesisRegulatory Sequences, Nucleic AcidRibosomesSubstrate SpecificityThermodynamicsViral LoadVirus ReplicationVitamin B 12ConceptsViral loadCobalamin concentrationsHCV viral loadVitamin B12HCV-infected liverDose-dependent mannerReporter gene in vitroEncephalomyocarditis virusGenes in vitroInternal ribosome entry site (IRES)-dependent translationHCVHCV replicationSwine fever virusCap-dependent mechanismSerum cobalamin concentrationsSerumHuman liverHuman serumIRES elementsLiverInhibit translationB12VitaminVirus functions