2019
Cell cycle dynamics in the reprogramming of cellular identity
Hu X, Eastman AE, Guo S. Cell cycle dynamics in the reprogramming of cellular identity. FEBS Letters 2019, 593: 2840-2852. PMID: 31562821, DOI: 10.1002/1873-3468.13625.Peer-Reviewed Original ResearchConceptsCell fate reprogrammingCell cycle dynamicsCellular identityDaughter cellsGenome replicationCell cycleSpecific cell cycle phasesCell fate regulationCell cycle controlRapid cell cyclesCell cycle phasesCycle dynamicsFate regulationEpigenomic changesCycle controlFate controlReprogrammingCell typesBiochemical processesReplicationComplex mechanismsCycle phaseGenomeCellsProminent example
2018
Dppa2/4 Facilitate Epigenetic Remodeling during Reprogramming to Pluripotency
Hernandez C, Wang Z, Ramazanov B, Tang Y, Mehta S, Dambrot C, Lee YW, Tessema K, Kumar I, Astudillo M, Neubert TA, Guo S, Ivanova NB. Dppa2/4 Facilitate Epigenetic Remodeling during Reprogramming to Pluripotency. Cell Stem Cell 2018, 23: 396-411.e8. PMID: 30146411, PMCID: PMC6128737, DOI: 10.1016/j.stem.2018.08.001.Peer-Reviewed Original ResearchConceptsInduced pluripotent stem cellsDNA damage response pathwayAcquisition of pluripotencyDamage response pathwayDNA methylation patternsStem cellsEmbryonic stem cellsESC enhancersPluripotent stem cellsMyc factorsPluripotent stateSomatic genesChromatin decompactionMolecular machineryEpigenetic remodelingEfficient reprogrammingResponse pathwaysSomatic cellsMethylation patternsPluripotencyHuman cellsEpigenomeEnhancerCellsKey role