2021
Prognostic impact of mismatch repair deficiency in high- and low-intermediate-risk, early-stage endometrial cancer following vaginal brachytherapy
Li JY, Park HS, Huang GS, Young MR, Ratner E, Santin A, Damast S. Prognostic impact of mismatch repair deficiency in high- and low-intermediate-risk, early-stage endometrial cancer following vaginal brachytherapy. Gynecologic Oncology 2021, 163: 557-562. PMID: 34602287, DOI: 10.1016/j.ygyno.2021.09.018.Peer-Reviewed Original ResearchConceptsRecurrence-free survivalEndometrioid endometrial cancerVaginal brachytherapyPMMR patientsOverall survivalEEC patientsEndometrial cancerExact testThree-year recurrence-free survivalEarly-stage endometrial cancerCox proportional hazards regressionPoor recurrence-free survivalAdjuvant vaginal brachytherapyThree-year OSMultivariable Cox regressionLympho-vascular invasionSignificant prognostic variablesProportional hazards regressionLog-rank testKaplan-Meier estimatesDeficient mismatch repairMismatch repair statusFisher's exact testMismatch repair deficiencyDMMR status
2012
Comparative patient-centered outcomes (health state and adverse sexual symptoms) between adjuvant brachytherapy versus no adjuvant brachytherapy in early-stage endometrial cancer.
Damast S, Alektiar K, Goldfarb S, Gerber N, Eaton A, Patil S, Mosenkis J, Sit L, Rogak L, Leitao M, Carter J, Basch E. Comparative patient-centered outcomes (health state and adverse sexual symptoms) between adjuvant brachytherapy versus no adjuvant brachytherapy in early-stage endometrial cancer. Journal Of Clinical Oncology 2012, 30: 9104-9104. DOI: 10.1200/jco.2012.30.15_suppl.9104.Peer-Reviewed Original ResearchFemale Sexual Function IndexSimple hysterectomyPoor sexual functioningFSFI scoreEndometrial cancerSexual functioningAdjuvant brachytherapyExact testEarly-stage endometrial cancerHealth statesStage I endometrial cancerBaseline sexual activityMedian FSFI scorePatient-centered outcomesSexual Function IndexWorse sexual functioningFisher's exact testWaiver of consentTreatment-related itemsCross-sectional analysisPoor health statesCurrent sexual functioningHormonal therapyPrimary endpointAlone group