Shari Damast, MD
Professor of Therapeutic RadiologyDownloadHi-Res Photo
Cards
Appointments
Therapeutic Radiology
Primary
Additional Titles
Chief, Gynecologic Radiotherapy Program, Therapeutic Radiology
Contact Info
Therapeutic Radiology
PO Box 208040
New Haven, CT 06520-8040
United States
Appointments
Therapeutic Radiology
Primary
Additional Titles
Chief, Gynecologic Radiotherapy Program, Therapeutic Radiology
Contact Info
Therapeutic Radiology
PO Box 208040
New Haven, CT 06520-8040
United States
Appointments
Therapeutic Radiology
Primary
Additional Titles
Chief, Gynecologic Radiotherapy Program, Therapeutic Radiology
Contact Info
Therapeutic Radiology
PO Box 208040
New Haven, CT 06520-8040
United States
About
Titles
Professor of Therapeutic Radiology
Chief, Gynecologic Radiotherapy Program, Therapeutic Radiology
Biography
Dr. Damast is board-certified radiation oncologist with a clinical and academic focus on treating gynecologic malignancies with radiation therapy. She has been on the faculty of the Department of Therapeutic Radiology at Yale since 2011, after completing her residency training in radiation oncology at Memorial Sloan-Kettering Cancer Center in New York City. Dr. Damast is a member of the American Society of Radiation Oncology (ASTRO), the American Brachytherapy Society (ABS), and the Scientific Network on Female Sexual Health and Cancer.
Appointments
Therapeutic Radiology
ProfessorPrimary
Other Departments & Organizations
Education & Training
- Residency
- Memorial Sloan Kettering Cancer Center (2011)
- Internship
- Beth Israel Medical Center - Petrie Division (2007)
- MD
- Weill Cornell Medical College (2006)
- BS
- Yale University (2002)
Research
Overview
Medical Subject Headings (MeSH)
Brachytherapy; Radiotherapy
Research at a Glance
Yale Co-Authors
Frequent collaborators of Shari Damast's published research.
Publications Timeline
A big-picture view of Shari Damast's research output by year.
Research Interests
Research topics Shari Damast is interested in exploring.
Christopher J. Tien, PhD, DABR, FAAPM
Henry S. Park, MD, MPH
Alessandro Santin, MD
Melissa Rasar Young, MD, PhD
Peter Schwartz, MD
Gloria Huang, MD, FACOG
72Publications
3,338Citations
Brachytherapy
Radiotherapy
Publications
2024
PO0205 Investigation of Inter-Observer Variability of Rectovaginal Reference Point Definition for Cervical Cancer Brachytherapy
Adefres B, Wallington D, Tien C, Damast S. PO0205 Investigation of Inter-Observer Variability of Rectovaginal Reference Point Definition for Cervical Cancer Brachytherapy. Brachytherapy 2024, 23: s96. DOI: 10.1016/j.brachy.2024.08.140.Peer-Reviewed Original ResearchConceptsExternal beam radiotherapyTreatment planning systemCervical cancer brachytherapyObserver 1Inter-observer variationObserver 2High dose rate brachytherapyDose gradientCombined external beam radiotherapyExternal beam radiotherapy doseDose measurementsPhysical doseCancer brachytherapyPosterior vaginal wallCervical cancer patientsBrachytherapy techniquesPlanning systemInter-observer differencesInter-observer variabilityBrachytherapy doseCumulative EQD2HDR-BTVaginal doseBeam radiotherapyVaginal wallPO0222 Feasibility of 3-D Printed Prototypes of Indwelling Intrauterine Tube for Tandem-Based Cervical Brachytherapy
Tien C, Damast S, Glennon A. PO0222 Feasibility of 3-D Printed Prototypes of Indwelling Intrauterine Tube for Tandem-Based Cervical Brachytherapy. Brachytherapy 2024, 23: s105. DOI: 10.1016/j.brachy.2024.08.156.Peer-Reviewed Original ResearchConceptsSmit sleeveIntrauterine tubeCervical brachytherapyAnimal modelsClinical useUtero timeCT imagesBeam radiationPrevent perforationBrachytherapyClinical prototypeIn-house methodologyClinicMinutesImplantationSTL fileSleeveCervixIntrauterineDaysUterusUteroLong-termCoefficient of thermal expansionISO testsSaturday, July 13, 202411:30 AM - 12:30 PMGSOR01 Presentation Time: 11:30 AM A Prospective Clinical Trial Assessing Comfort of Brachytherapy with a Novel Tapered Vaginal Applicator
Mahal A, Yu J, Mahal R, Tien C, Adefres B, Damast S. Saturday, July 13, 202411:30 AM - 12:30 PMGSOR01 Presentation Time: 11:30 AM A Prospective Clinical Trial Assessing Comfort of Brachytherapy with a Novel Tapered Vaginal Applicator. Brachytherapy 2024, 23: s72-s73. DOI: 10.1016/j.brachy.2024.08.099.Peer-Reviewed Original ResearchConceptsVisual-analogue-scaleVaginal brachytherapyVaginal stretchingVaginal applicationEndometrial cancerAssociated with less painIr-192 seedsDose fall-offClinically significant responseProspective clinical trialPatient-centered evaluationVaginal introitusProspective trialsDose distributionSurface doseVaginal mucosaIr-192Less painNarrow introitusPaired t-testEC patientsConsenting patientsClinical trialsIntroitusPatientsThe Prognostic Impact of MLH1 Promoter Hypermethylation in Stage I-II Endometrial Cancer Treated with Adjuvant Radiotherapy
Sherwani Z, Damast S, Fields E, Shah S, Beriwal S, Horne Z, Parks E, Kidd E, Leung E, Khoja L, Taunk N, Chino J, Huang C, Russo A, Dyer M, Albuquerque K, Hathout L. The Prognostic Impact of MLH1 Promoter Hypermethylation in Stage I-II Endometrial Cancer Treated with Adjuvant Radiotherapy. International Journal Of Radiation Oncology • Biology • Physics 2024, 120: s32. DOI: 10.1016/j.ijrobp.2024.07.044.Peer-Reviewed Original ResearchConceptsRecurrence-free survivalExternal beam radiationMismatch repair statusOverall survivalAdjuvant radiotherapyVaginal brachytherapyAssociated with decreased RFSPromoter hypermethylationInferior recurrence-free survivalProportion of locoregional recurrenceTreated with adjuvant radiotherapyDepth of myometrial invasionLympho-vascular space invasionMulti-institutional cohort studyRetrospective multi-institutional cohort studyCervical stromal involvementSite of recurrenceKaplan Meier methodPost-surgical resectionCox proportional hazards modelsMulti-institutional studyDeficient mismatch repairProportional hazards modelImpact OSLocoregional recurrenceVulvar Cancer, Version 3.2024, NCCN Clinical Practice Guidelines in Oncology.
Abu-Rustum N, Yashar C, Arend R, Barber E, Bradley K, Brooks R, Campos S, Chino J, Chon H, Crispens M, Damast S, Fisher C, Frederick P, Gaffney D, Gaillard S, Giuntoli R, Glaser S, Holmes J, Howitt B, Kendra K, Lea J, Lee N, Mantia-Smaldone G, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Podoll M, Rodabaugh K, Salani R, Schorge J, Siedel J, Sisodia R, Soliman P, Ueda S, Urban R, Wethington S, Wyse E, Zanotti K, McMillian N, Espinosa S. Vulvar Cancer, Version 3.2024, NCCN Clinical Practice Guidelines in Oncology. Journal Of The National Comprehensive Cancer Network 2024, 22: 117-135. PMID: 38503056, DOI: 10.6004/jnccn.2024.0013.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsNCCN Clinical Practice GuidelinesVulvar cancerClinical practice guidelinesCell carcinomaHistologically squamous cell carcinomaSystemic therapy optionsSquamous cell carcinomaBasal cell carcinomaExtramammary Paget's diseasePractice guidelinesVerrucous carcinomaGynecologic malignanciesHuman papillomavirusVulvar neoplasiaTherapy optionsPaget's diseaseInflammatory conditionsRisk factorsCigarette smokingCarcinomaCancerIncreasing ageHistologyNCCNVulvarPrognostic Effect of Mismatch Repair Status in Early-Stage Endometrial Cancer Treated With Adjuvant Radiation: A Multi-institutional Analysis
Hathout L, Sherwani Z, Alegun J, Ohri N, Fields E, Shah S, Beriwal S, Horne Z, Kidd E, Leung E, Song J, Taunk N, Chino J, Huang C, Russo A, Dyer M, Li J, Albuquerque K, Damast S. Prognostic Effect of Mismatch Repair Status in Early-Stage Endometrial Cancer Treated With Adjuvant Radiation: A Multi-institutional Analysis. International Journal Of Radiation Oncology • Biology • Physics 2024, 119: 1158-1165. PMID: 38253292, DOI: 10.1016/j.ijrobp.2024.01.203.Peer-Reviewed Original ResearchAltmetricConceptsRecurrence-free survivalEndometrioid endometrial adenocarcinomaMismatch repair statusAdjuvant radiation therapyOverall survivalRadiation therapyVaginal brachytherapyMismatch repair deficiencyAssociated with worse recurrence-free survivalMulti-institutional retrospective cohort studyTreated with adjuvant radiation therapyAssociated with recurrence-free survivalMultivariate analysisExternal beam radiation therapyRecurrence-free survival ratesMismatch repair deficiency statusBeam radiation therapyGrades 1 to 2Kaplan-Meier methodOutcomes of patientsMulti-institutional analysisRetrospective cohort studyCox proportional hazards modelsProportional hazards modelAdjuvant radiation
2023
NCCN Guidelines® Insights: Cervical Cancer, Version 1.2024.
Abu-Rustum N, Yashar C, Arend R, Barber E, Bradley K, Brooks R, Campos S, Chino J, Chon H, Crispens M, Damast S, Fisher C, Frederick P, Gaffney D, Gaillard S, Giuntoli R, Glaser S, Holmes J, Howitt B, Lea J, Mantia-Smaldone G, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Podoll M, Rodabaugh K, Salani R, Schorge J, Siedel J, Sisodia R, Soliman P, Ueda S, Urban R, Wyse E, McMillian N, Aggarwal S, Espinosa S. NCCN Guidelines® Insights: Cervical Cancer, Version 1.2024. Journal Of The National Comprehensive Cancer Network 2023, 21: 1224-1233. PMID: 38081139, DOI: 10.6004/jnccn.2023.0062.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCervical cancerNCCN guidelinesNCCN Guidelines InsightsSystemic therapy recommendationsAdvanced cervical cancerMetastatic diseaseTreatment landscapeClinical outcomesDiagnostic workupHistopathologic classificationTherapy recommendationsCancerMolecular profileAspects of managementRecent updatesDiagnostic featuresGuidelinesWorkupStagingDiseaseRecurrentPathologyInvestigating the Relationship between the Dose to the Recto-Vaginal Reference Point and Vaginal Stenosis among Cervical Cancer Patients Treated at a North American Academic Institution
Adefres B, Wallington D, Tien C, Damast S. Investigating the Relationship between the Dose to the Recto-Vaginal Reference Point and Vaginal Stenosis among Cervical Cancer Patients Treated at a North American Academic Institution. International Journal Of Radiation Oncology • Biology • Physics 2023, 117: e501. DOI: 10.1016/j.ijrobp.2023.06.1746.Peer-Reviewed Original ResearchConceptsVaginal stenosisDose constraintsMedian doseMultivariable Cox proportional hazards regressionCox proportional hazards regressionCohort median ageAdvanced cervical cancerInterstitial needlesKaplan-Meier methodCervical cancer patientsProportional hazards regressionLog-rank testHR-CTV D90MATERIAL/METHODSImage-guided brachytherapyNorth American academic institutionsLACC patientsPrimary endpointCumulative incidenceOnly patientsPatient demographicsMedian ageCervical cancerCancer patientsSingle institutionPrognostic Impact of Mismatch Repair Deficiency on Stage I-II Endometrioid Endometrial Cancer Treated with Adjuvant Radiation Therapy: A Multi-Institutional Analysis
Sherwani Z, Alegun J, Russo A, Damast S, Albuquerque K, Nwachukwu C, Dyer M, Fields E, Beriwal S, Horne Z, Vergalasova I, Ohri N, Taunk N, Chino J, Kidd E, Leung E, Song J, Hathout L. Prognostic Impact of Mismatch Repair Deficiency on Stage I-II Endometrioid Endometrial Cancer Treated with Adjuvant Radiation Therapy: A Multi-Institutional Analysis. International Journal Of Radiation Oncology • Biology • Physics 2023, 117: s8. DOI: 10.1016/j.ijrobp.2023.06.217.Peer-Reviewed Original ResearchConceptsEndometrioid endometrial cancerEarly-stage endometrioid endometrial cancerExternal beam radiation therapyAdjuvant radiation therapyLymphovascular space invasionOverall survivalGrade 3Radiation therapyStage IMultivariate analysisWorse RFSWorse OSEndometrial cancerUnivariate analysisMulti-institutional retrospective cohort studyFIGO 2009 stage IRecurrence-free survival ratesCox proportional hazards modelPost-surgical stagingRetrospective cohort studyKaplan-Meier methodDeep myometrial invasionFIGO grade 1Proportional hazards modelBeam radiation therapyPO38 Clinical Outcomes Following Brachytherapy for Endometrial Cancer Patients with Narrow Vaginal Anatomy
Adefres B, Tien C, Damast S. PO38 Clinical Outcomes Following Brachytherapy for Endometrial Cancer Patients with Narrow Vaginal Anatomy. Brachytherapy 2023, 22: s84-s85. DOI: 10.1016/j.brachy.2023.06.139.Peer-Reviewed Original ResearchConceptsVaginal cuff brachytherapyVaginal recurrenceEndometrial cancerEC patientsVaginal surfaceClinical outcomesVaginal anatomyGrade 2Single-channel vaginal cylinderStage IVb endometrial cancerAdjuvant vaginal cuff brachytherapyConsecutive EC patientsEndometrial cancer patientsExcellent local controlKaplan-Meier methodExternal beam radiotherapyInsertional painBaseline painVaginal stenosisCTCAE v4.0Patient demographicsStage IIIAUrinary toxicityMedian ageMedian BMI
Clinical Trials
Current Trials
Parallel Phase III Randomized Trials for High Risk Prostate Cancer Evaluating De-Intensification for Lower Genomic Risk and Intensification of Concurrent Therapy for Higher Genomic Risk With Radiation (PREDICT-RT*)
HIC ID2000032279RoleSub InvestigatorPrimary Completion Date12/31/2033Recruiting Participants
Academic Achievements & Community Involvement
honor 2020 Yale Cancer Center Award for Clinical Excellence
Yale School of Medicine AwardDetails01/26/2021United Stateshonor 2019-2020 ARRO Educator of the Year Award
Other AwardDetails04/15/2020United Stateshonor YNHH/Smilow Cancer Hospital Luminary Award of Excellence
Other AwardDetails09/10/2019United Stateshonor ABR Volunteer Service Award
Other AwardDetails05/15/2019United States
Clinical Care
Overview
Clinical Specialties
Therapeutic Radiology; Gynecologic Oncology
Fact Sheets
Brachytherapy
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News
- January 29, 2024
Comprehensive Breast Cancer Care at Smilow Cancer Hospital in New Haven
- March 13, 2023
Christopher J. Tien, PhD awarded pilot grant
- March 02, 2023
Gynecologic Oncology Specialty Team at Smilow Cancer Hospital Care Center in Trumbull
- June 23, 2022
Smilow Cancer Hospital Care Centers at Trumbull and Fairfield
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Academic Office Number
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Mailing Address
Therapeutic Radiology
PO Box 208040
New Haven, CT 06520-8040
United States
Locations
Yale Therapeutic Radiology
Academic Office
Hunter Building
15 York Street, Ste HRT 136
New Haven, CT 06510
Patient Care Locations
Are You a Patient? View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.