2020
High-throughput quantitative histology in systemic sclerosis skin disease using computer vision
Correia C, Mawe S, Lofgren S, Marangoni RG, Lee J, Saber R, Aren K, Cheng M, Teaw S, Hoffmann A, Goldberg I, Cowper SE, Khatri P, Hinchcliff M, Mahoney JM. High-throughput quantitative histology in systemic sclerosis skin disease using computer vision. Arthritis Research & Therapy 2020, 22: 48. PMID: 32171325, PMCID: PMC7071594, DOI: 10.1186/s13075-020-2127-0.Peer-Reviewed Original ResearchConceptsSystemic sclerosisFibrosis scoreQuantitative image featuresBiopsy scorePrimary cohortOutcome measuresSecondary cohortDiagnostic scoreSkin severity scoreSSc clinical trialsRodnan skin scoreLogistic regression modelsControl biopsiesRegression modelsSkin scoreSeverity scoreClinical hallmarkClinical trialsForearm biopsiesSSc skinBiopsy sectionsIndependent cohortPatient basisSSc biopsiesCollagen deposition
2009
Nephrogenic Systemic Fibrosis and Other Scleroderma Mimickers
Perazella M, Pope J, Cowper S. Nephrogenic Systemic Fibrosis and Other Scleroderma Mimickers. 2009, 97-106. DOI: 10.1007/978-1-84800-934-9_11.ChaptersNephrogenic systemic fibrosisCases of NSFSystemic fibrosisDiagnosis of NSFRisk of NSFDose of gadoliniumUnderlying renal diseaseYellow scleral plaquesDermal dendritic cellsNormal kidney functionSystemic fibrosing disorderScar-like fibrosisFibrocyte-like cellsExtracutaneous diseaseSymmetrical edemaEosinophilic fasciitisRenal insufficiencyAntinuclear antibodiesDendritic cellsFibrosing disorderRenal diseaseSystemic sclerosisHistopathological featuresHistopathological findingsKidney function