2020
High-throughput quantitative histology in systemic sclerosis skin disease using computer vision
Correia C, Mawe S, Lofgren S, Marangoni RG, Lee J, Saber R, Aren K, Cheng M, Teaw S, Hoffmann A, Goldberg I, Cowper SE, Khatri P, Hinchcliff M, Mahoney JM. High-throughput quantitative histology in systemic sclerosis skin disease using computer vision. Arthritis Research & Therapy 2020, 22: 48. PMID: 32171325, PMCID: PMC7071594, DOI: 10.1186/s13075-020-2127-0.Peer-Reviewed Original ResearchConceptsSystemic sclerosisFibrosis scoreQuantitative image featuresBiopsy scorePrimary cohortOutcome measuresSecondary cohortDiagnostic scoreSkin severity scoreSSc clinical trialsRodnan skin scoreLogistic regression modelsControl biopsiesRegression modelsSkin scoreSeverity scoreClinical hallmarkClinical trialsForearm biopsiesSSc skinBiopsy sectionsIndependent cohortPatient basisSSc biopsiesCollagen deposition
2009
Gadolinium‐containing magnetic resonance image contrast agent promotes fibrocyte differentiation
Vakil V, Sung JJ, Piecychna M, Crawford JR, Kuo P, Abu‐Alfa A, Cowper SE, Bucala R, Gomer RH. Gadolinium‐containing magnetic resonance image contrast agent promotes fibrocyte differentiation. Journal Of Magnetic Resonance Imaging 2009, 30: 1284-1288. PMID: 19937928, PMCID: PMC2787835, DOI: 10.1002/jmri.21800.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear cellsNephrogenic systemic fibrosisSerum amyloid PFibrocyte differentiationDifferentiation of monocytesNSF patientsBlood mononuclear cellsHemodialysis patientsInterleukin-12Mononuclear cellsPurified monocytesFibroblast-like cellsFibrotic lesionsHealthy controlsSystemic fibrosisAmyloid PContrast agentsPatientsMonocytesDifferentiation inhibitorWiley-LissFibrocytesOmniscanDifferentiation protocolsCells
2007
Nephrogenic systemic fibrosis: a case series suggesting gadolinium as a possible aetiological factor
Moreno‐Romero J, Segura S, Mascaró JM, Cowper SE, Julià M, Poch E, Botey A, Herrero C. Nephrogenic systemic fibrosis: a case series suggesting gadolinium as a possible aetiological factor. British Journal Of Dermatology 2007, 157: 783-787. PMID: 17627792, DOI: 10.1111/j.1365-2133.2007.08067.x.Peer-Reviewed Original ResearchConceptsNephrogenic systemic fibrosisDevelopment of NSFRenal insufficiency patientsOnset of symptomsNephrogenic fibrosing dermopathyPossible aetiological factorsMagnetic resonance angiographyRenal diseaseCase seriesAetiological factorsSystemic fibrosisResonance angiographyFibrotic conditionsPatientsParamagnetic contrast agentHistory of useDiseaseContrast agentsAngiographyFibrosisDermopathyEtiologyGadoliniumSymptoms
2005
Cellular digital fibromas: distinctive CD34‐positive lesions that may mimic dermatofibrosarcoma protuberans
McNiff JM, Subtil A, Cowper SE, Lazova R, Glusac EJ. Cellular digital fibromas: distinctive CD34‐positive lesions that may mimic dermatofibrosarcoma protuberans. Journal Of Cutaneous Pathology 2005, 32: 413-418. PMID: 15953374, DOI: 10.1111/j.0303-6987.2005.00358.x.Peer-Reviewed Original Research
2003
Nephrogenic fibrosing dermopathy: the first 6 years
Cowper SE. Nephrogenic fibrosing dermopathy: the first 6 years. Current Opinion In Rheumatology 2003, 15: 785-790. PMID: 14569211, DOI: 10.1097/00002281-200311000-00017.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsNephrogenic fibrosing dermopathyRecent case reportsCase reportCutaneous fibrosing disorderYellow scleral plaquesDistinct clinical patternsDual immunohistochemical stainingAntiphospholipid antibodiesRenal insufficiencyClinical patternDual immunolabelingFibrosing disorderSystemic disordersClinical spectrumScleral plaquesDisease onsetEpidemiologic dataSpindle cellsImmunohistochemical stainingDisease triggersSkin conditionsDisease pathogenesisNormal skinRegistry projectDiagnostic tests
2001
Nephrogenic Fibrosing Dermopathy
Cowper S, Su L, Bhawan J, Robin H, LeBoit P. Nephrogenic Fibrosing Dermopathy. American Journal Of Dermatopathology 2001, 23: 383-393. PMID: 11801769, DOI: 10.1097/00000372-200110000-00001.Peer-Reviewed Original ResearchConceptsNephrogenic fibrosing dermopathyElastic fibersPositive dermal dendrocytesCollagen bundlesDifferent kidney diseasesThick collagen bundlesRenal transplantCutaneous changesDendritic cellsFibrosing disorderRenal diseaseSystemic findingsIndurated plaquesDermal mucinKidney diseaseSingle institutionDermal dendrocytesDialysis centersHistopathologic examinationHistopathologic findingsRenal dialysisEntire dermisSpindle cellsEarly lesionsRoutine microscopy
2000
Scleromyxoedema-like cutaneous diseases in renal-dialysis patients
Cowper S, Robin H, Steinberg S, Su L, Gupta S, LeBoit P. Scleromyxoedema-like cutaneous diseases in renal-dialysis patients. The Lancet 2000, 356: 1000-1001. PMID: 11041404, DOI: 10.1016/s0140-6736(00)02694-5.Commentaries, Editorials and Letters
1999
Expression of p-27 (kip1) in Nevi and Melanomas
Morgan M, Cowper S. Expression of p-27 (kip1) in Nevi and Melanomas. American Journal Of Dermatopathology 1999, 21: 121-124. PMID: 10218670, DOI: 10.1097/00000372-199904000-00002.Peer-Reviewed Original ResearchConceptsExpression of p27Melanocytic lesionsSpitz neviDistribution of immunoreactivityP27 labeling indexMinority of casesCell cycle inhibitory proteinsChart reviewMalignant melanocytic lesionsClinical historyDiagnostic challengeBiologic behaviorHistopathologic criteriaLabeling indexCompound neviLogistic regressionHuman neoplasmsNeviNuclear stainingLesionsMelanomaP27Inhibitory proteinAccurate distinctionSkin