Two types of precursor cells in a multipotential hematopoietic cell line
Ye ZJ, Kluger Y, Lian Z, Weissman SM. Two types of precursor cells in a multipotential hematopoietic cell line. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 18461-18466. PMID: 16352715, PMCID: PMC1317970, DOI: 10.1073/pnas.0509314102.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CD34Cell DifferentiationCell LineGene Expression ProfilingGene Expression RegulationGlobinsHematopoietic Stem CellsMiceMultipotent Stem CellsOligonucleotide Array Sequence AnalysisPhosphorylationProtein BindingProto-Oncogene Proteins c-kitReceptors, Interleukin-3Transcription FactorsConceptsMultipotential hematopoietic cell linePrecursor cellsBeta-globin transcriptionCell linesMultipotential cell lineLocus control region hypersensitive site-2CD34- populationHypersensitive site 2Hematopoietic cell linesStem cell factor receptorPresence of SCFHematopoietic differentiationCell factor receptorDevelopmental transitionsNormal developmental transitionsCytokines IL-3Growth responseCell surface markersFactor receptorIL-3Mixed populationSite 2CellsSurface markersDifferent rolesWerner Protein Protects Nonproliferating Cells from Oxidative DNA Damage
Szekely AM, Bleichert F, Nümann A, Van Komen S, Manasanch E, Nasr A, Canaan A, Weissman SM. Werner Protein Protects Nonproliferating Cells from Oxidative DNA Damage. Molecular And Cellular Biology 2005, 25: 10492-10506. PMID: 16287861, PMCID: PMC1291253, DOI: 10.1128/mcb.25.23.10492-10506.2005.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphatasesCell ProliferationCells, CulturedCellular SenescenceDNADNA DamageDNA HelicasesDNA ReplicationExodeoxyribonucleasesFibroblastsGene Expression RegulationHumansOxidation-ReductionOxidative StressOxygenRecQ HelicasesRNA InterferenceTelomeric Repeat Binding Protein 2Werner Syndrome HelicaseConceptsDNA damage responseWerner syndromeDamage responseDNA damageRNA interferenceOxidative DNA damageWRN-depleted cellsInduction of gammaH2AXDNA damage fociCellular senescence phenotypePrimary human fibroblastsWRN depletionWerner proteinWRN proteinNuclear fociWRN deficiencyProtein TRF2Telomere maintenanceAcute oxidative stressBLM expressionDNA homeostasisDNA replicationDamage fociSenescence phenotypePhysiological oxygen