Advances in Ischemia Reperfusion Injury Prevention in Free Flaps and Vascularized Composite Allotransplantation
Hadzimustafic N, D’Elia A, Duru C, Haykal S. Advances in Ischemia Reperfusion Injury Prevention in Free Flaps and Vascularized Composite Allotransplantation. 2024, 4 DOI: 10.5772/intechopen.112993.Peer-Reviewed Original ResearchIschemia-reperfusion injuryVascularized composite allotransplantationFree flapsStatic cold storagePharmacological strategiesAdvanced reconstructive optionsAttenuation of ischemia-reperfusion injuryIrreversible ischemic damagePost-operative monitoringStem cell strategiesPre-clinical studiesPlastic and Reconstructive SurgeryPost-ischemic periodPost-ischemicReperfusion injuryReconstructive optionsIschemia-reperfusionPre-ischemicReconstructive surgeryIschemic periodPre-ischemic periodIschemic damageClinical toolFlapMachine perfusionImmune modulation in transplant medicine: a comprehensive review of cell therapy applications and future directions
Knoedler L, Dean J, Diatta F, Thompson N, Knoedler S, Rhys R, Sherwani K, Ettl T, Mayer S, Falkner F, Kilian K, Panayi A, Iske J, Safi A, Tullius S, Haykal S, Pomahac B, Kauke-Navarro M. Immune modulation in transplant medicine: a comprehensive review of cell therapy applications and future directions. Frontiers In Immunology 2024, 15: 1372862. PMID: 38650942, PMCID: PMC11033354, DOI: 10.3389/fimmu.2024.1372862.Peer-Reviewed Original ResearchConceptsRegulatory myeloid cellsSolid organ transplantationVascularized composite allotransplantationMesenchymal stromal cellsT cellsTransplant patientsCellular therapyChimeric antigen receptor T cellsTransplant surgerySide effectsIncreased risk of malignancyProgression to chronic rejectionAcute rejection ratesPerioperative treatment strategiesRegulatory T cellsPromote immune toleranceRisk of malignancySystemic side effectsRelated side effectsCell typesImprove transplant survivalCAR-TCell therapy applicationsImmunosuppressive regimensChronic rejection