2018
What Mediated Pioglitazone's Cardiovascular (CV) Benefit in the IRIS Trial?
INZUCCHI S, VISCOLI C, YOUNG L, GORMAN M, CONWIT R, SCHWARTZ G, KERNAN W. What Mediated Pioglitazone's Cardiovascular (CV) Benefit in the IRIS Trial? Diabetes 2018, 67 DOI: 10.2337/db18-17-lb.Peer-Reviewed Original ResearchTransient ischemic attackDensity lipoprotein cholesterolInsulin resistanceCV benefitsLog HRCardiovascular benefitsLipoprotein cholesterolBlood pressureStroke/transient ischemic attackHigh-sensitivity C-reactive proteinHigh-density lipoprotein cholesterolLow-density lipoprotein cholesterolMeasures of IRInsulin Resistance InterventionHomeostatic model assessmentDiastolic blood pressureEffect of pioglitazoneSystolic blood pressureC-reactive proteinFavorable effectBoehringer Ingelheim PharmaceuticalsPIO effectIschemic attackNondiabetic patientsHOMA-IR
2008
Cardiovascular risk-benefit ratio of thiazolidinediones
Lipska K, Inzucchi S. Cardiovascular risk-benefit ratio of thiazolidinediones. Current Cardiovascular Risk Reports 2008, 3: 42-50. DOI: 10.1007/s12170-009-0008-9.Peer-Reviewed Original ResearchRisk-benefit ratioType 2 diabetes mellitusActual cardiovascular outcomesSurrogates of atherosclerosisDifferential clinical effectsInsulin-sensitizing thiazolidinedionesEffective antihyperglycemic agentCardiovascular eventsCardiovascular outcomesCardiovascular implicationsBlood pressureDiabetes mellitusEndothelial functionHeart failureClinical effectsInsulin resistanceAntihyperglycemic agentsFluid retentionLipid profileThiazolidinedionesPatientsAvailable membersBeneficial impactMellitusT2DM