T Cell-Derived Protein S Engages TAM Receptor Signaling in Dendritic Cells to Control the Magnitude of the Immune Response
Silva E, Chan PY, Joannas L, Errasti AE, Gagliani N, Bosurgi L, Jabbour M, Perry A, Smith-Chakmakova F, Mucida D, Cheroutre H, Burstyn-Cohen T, Leighton JA, Lemke G, Ghosh S, Rothlin CV. T Cell-Derived Protein S Engages TAM Receptor Signaling in Dendritic Cells to Control the Magnitude of the Immune Response. Immunity 2013, 39: 160-170. PMID: 23850380, PMCID: PMC4017237, DOI: 10.1016/j.immuni.2013.06.010.Peer-Reviewed Original ResearchMeSH KeywordsAdaptive ImmunityAnimalsCells, CulturedColitisCytokinesDendritic CellsFlow CytometryGene ExpressionHumansImmunoblottingLymphocyte ActivationMiceMice, KnockoutMice, TransgenicProtein SReceptor Protein-Tyrosine KinasesReverse Transcriptase Polymerase Chain ReactionSignal TransductionT-LymphocytesConceptsImmune responseDC activationProtein STAM receptor signalingDendritic cell activationExaggerated immune responseTAM receptor tyrosine kinasesDendritic cellsChronic inflammationCostimulatory moleculesImmune homeostasisAdaptive immunityCell activationInnate immunityGenetic ablationReceptor tyrosine kinasesReceptor signalingImmune defenseNegative feedback mechanismMouse TImmunityActivationTyrosine kinaseCellsPROS1