2020
Sex differences in the role of atypical PKC within the basolateral nucleus of the amygdala in a mouse hyperalgesic priming model
Baptista-de-Souza D, Tavares-Ferreira D, Megat S, Sankaranarayanan I, Shiers S, Flores CM, Ghosh S, Nunes-de-Souza R, Canto-de-Souza A, Price TJ. Sex differences in the role of atypical PKC within the basolateral nucleus of the amygdala in a mouse hyperalgesic priming model. Neurobiology Of Pain 2020, 8: 100049. PMID: 32548337, PMCID: PMC7284072, DOI: 10.1016/j.ynpai.2020.100049.Peer-Reviewed Original ResearchHyperalgesic primingPlantar incisionFemale miceBasolateral nucleusHyperalgesic priming modelSucrose splash testSex differencesPain-related behaviorsIntra-BLA microinjectionGluA2-containing AMPA receptorsDistinct brain regionsMechanical hypersensitivityPain mechanismsAberrant behavioral responsesChronic painFacial grimacingBody of evidenceMale miceSplash testPain unpleasantnessProstaglandin EAMPA receptorsGluA2 expressionUnderlying neural mechanismsBrain regions
2013
BDNF Regulates Atypical PKC at Spinal Synapses to Initiate and Maintain a Centralized Chronic Pain State
Melemedjian OK, Tillu DV, Asiedu MN, Mandell EK, Moy JK, Blute VM, Taylor CJ, Ghosh S, Price TJ. BDNF Regulates Atypical PKC at Spinal Synapses to Initiate and Maintain a Centralized Chronic Pain State. Molecular Pain 2013, 9: 1744-8069-9-12. PMID: 23510079, PMCID: PMC3608966, DOI: 10.1186/1744-8069-9-12.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain-Derived Neurotrophic FactorCalcium-Calmodulin-Dependent Protein Kinase Type 2Cerebral CortexChronic PainEukaryotic Initiation Factor-4FExtracellular Signal-Regulated MAP KinasesMaleMAP Kinase Signaling SystemMiceMice, Inbred ICRMitogen-Activated Protein Kinase KinasesModels, BiologicalPhosphorylationPosterior Horn CellsProtein BiosynthesisProtein Kinase CProtein TransportSynapsesTime FactorsTOR Serine-Threonine KinasesConceptsChronic pain statesPain statesPersistent nociceptive sensitizationSpinal synapsesChronic painNociceptive sensitizationPotential therapeutic targetImportant medical problemNeurotrophic factorBDNF regulationPersistent sensitizationBDNFTherapeutic targetMedical problemsPainNovel therapeuticsEssential mediatorSensitizationPermanent reversalSynapsesMolecular linkPKMζKey regulatorZIPping to Pain Relief: The Role (or Not) of PKMζ in Chronicc Pain
Price TJ, Ghosh S. ZIPping to Pain Relief: The Role (or Not) of PKMζ in Chronicc Pain. Molecular Pain 2013, 9: 1744-8069-9-6. PMID: 23433248, PMCID: PMC3621284, DOI: 10.1186/1744-8069-9-6.BooksConceptsChronic pain statesChronic painLong-term potentiationAnterior cingulate cortexPain statesPain plasticityCertain chronic pain statesRole of PKMζSpinal dorsal hornChronic pain developmentSignificant clinical problemPotential roleSuch off-target effectsPain reliefDorsal hornPain developmentCNS areasCNS regionsClinical problemNociceptor stimulationPainCingulate cortexNew targetsKey moleculesOff-target effects