2023
Age-dependent differences in efferocytosis determine the outcome of opsonophagocytic protection from invasive pathogens
Bee G, Lokken-Toyli K, Yeung S, Rodriguez L, Zangari T, Anderson E, Ghosh S, Rothlin C, Brodin P, Khanna K, Weiser J. Age-dependent differences in efferocytosis determine the outcome of opsonophagocytic protection from invasive pathogens. Immunity 2023, 56: 1255-1268.e5. PMID: 37059107, PMCID: PMC10330046, DOI: 10.1016/j.immuni.2023.03.018.Peer-Reviewed Original ResearchConceptsAge-dependent differencesNeonatal neutrophilsEarly lifeModulation of CD11bCD11b surface expressionAge-dependent susceptibilitySpn infectionPeripheral bloodMore CD11bMouse modelInfection outcomesStreptococcus pneumoniaeNeutrophilsCD11bEfferocytosisSystemic expressionSurface expressionNeonatesOpsonophagocytosisInvasive pathogensOutcomesPopulation levelCD169PathogensExpression
2010
Telomere-independent Rap1 is an IKK adaptor and regulates NF-κB-dependent gene expression
Teo H, Ghosh S, Luesch H, Ghosh A, Wong ET, Malik N, Orth A, de Jesus P, Perry AS, Oliver JD, Tran NL, Speiser LJ, Wong M, Saez E, Schultz P, Chanda SK, Verma IM, Tergaonkar V. Telomere-independent Rap1 is an IKK adaptor and regulates NF-κB-dependent gene expression. Nature Cell Biology 2010, 12: 758-767. PMID: 20622870, DOI: 10.1038/ncb2080.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBlotting, WesternCell LineCell Line, TumorChromatin ImmunoprecipitationChromatography, GelHeLa CellsHumansI-kappa B KinaseImmunohistochemistryImmunoprecipitationKaplan-Meier EstimateMiceNF-kappa BPhosphorylationPolymerase Chain ReactionProtein BindingRNA, Small InterferingShelterin ComplexTelomere-Binding ProteinsTissue Array Analysis