Featured Publications
DNA methylation of the promoter region at the CREB1 binding site is a mechanism for the epigenetic regulation of brain-specific PKMζ
Pramio D, Vieceli F, Varella-Branco E, Goes C, Kobayashi G, da Silva Pelegrina D, de Moraes B, El Allam A, De Kumar B, Jara G, Farfel J, Bennett D, Kundu S, Viapiano M, Reis E, de Oliveira P, Dos Santos E Passos-Bueno M, Rothlin C, Ghosh S, Schechtman D. DNA methylation of the promoter region at the CREB1 binding site is a mechanism for the epigenetic regulation of brain-specific PKMζ. Biochimica Et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 2023, 1866: 194909. PMID: 36682583, PMCID: PMC10037092, DOI: 10.1016/j.bbagrm.2023.194909.Peer-Reviewed Original ResearchConceptsInduced pluripotent stem cellsInternal promoterNeuronal differentiationEpigenetic mechanismsDNA methylationUpstream promoterProtein kinase C ζHuman neuronal differentiationSite-specific hypermethylationAberrant DNA hypermethylationPluripotent stem cellsEpigenetic regulationSame epigenetic mechanismsLong-term memory formationDNA hypermethylationDemethylated regionsEpigenetic factorsPromoter regionTissue specificityMolecular mechanismsPRKCZ geneDifferentiated neuronsPromoterProtein kinase M zetaLong-term potentiation
2019
aPKC in neuronal differentiation, maturation and function
Hapak SM, Rothlin CV, Ghosh S. aPKC in neuronal differentiation, maturation and function. Neuronal Signaling 2019, 3: ns20190019. PMID: 32269838, PMCID: PMC7104321, DOI: 10.1042/ns20190019.BooksProtein kinase C (PKC) familyAtypical protein kinase CsProtein kinase CsKey metabolic functionsNervous system developmentHuman neuropsychiatric diseasesC familyCellular responsesAPKCsNeural developmentNeuronal differentiationFunctional roleMetabolic functionsNervous systemNeuronal maturationNeuronal functionGenetic deletionKinaseGlucose uptakeDifferentiationLikely candidateMaturationNeuropsychiatric diseasesSubfamiliesPRKCI