2024
In the Eyes of the Beholder—New Mertk Knockout Mouse and Re-Evaluation of Phagocytosis versus Anti-Inflammatory Functions of MERTK
Ghosh S, Finnemann S, Vollrath D, Rothlin C. In the Eyes of the Beholder—New Mertk Knockout Mouse and Re-Evaluation of Phagocytosis versus Anti-Inflammatory Functions of MERTK. International Journal Of Molecular Sciences 2024, 25: 5299. PMID: 38791338, PMCID: PMC11121519, DOI: 10.3390/ijms25105299.Peer-Reviewed Original ResearchReceptor tyrosine kinasesFamily of receptor tyrosine kinasesTAM family of receptor tyrosine kinasesEarly-onset photoreceptor degenerationKnockout mouse modelMolecular functionsNegative regulator of inflammationKnockout phenotypesNegative regulatorMouse geneticsRegulation of inflammationMolecular approachesEmbryonic stem cellsAnti-inflammatory functionsRetinal degenerationTyrosine kinasePhotoreceptor degenerationKnockout miceKnockout modelsMouse modelRodent modelsTAM familyMerTK functionStem cellsAlleles
2018
Coagulopathies and inflammatory diseases: ‘…glimpse of a Snark’
del Carmen S, Hapak SM, Ghosh S, Rothlin CV. Coagulopathies and inflammatory diseases: ‘…glimpse of a Snark’. Current Opinion In Immunology 2018, 55: 44-53. PMID: 30268838, PMCID: PMC6366937, DOI: 10.1016/j.coi.2018.09.005.BooksConceptsAnti-pathogen defenseUnderlying molecular basisInflammatory diseasesMolecular basisSelective pressureHost defense mechanismsSubset of patientsDefense mechanismsVertebratesRegulation of inflammationHuman populationThrombophilic stateTherapeutic roleDefenseDiseaseInvertebratesCoagulopathyInflammationPhysical injuryMutationsRegulationPathogensCascadeApixabanThrombophilia