2010
Telomere-independent Rap1 is an IKK adaptor and regulates NF-κB-dependent gene expression
Teo H, Ghosh S, Luesch H, Ghosh A, Wong ET, Malik N, Orth A, de Jesus P, Perry AS, Oliver JD, Tran NL, Speiser LJ, Wong M, Saez E, Schultz P, Chanda SK, Verma IM, Tergaonkar V. Telomere-independent Rap1 is an IKK adaptor and regulates NF-κB-dependent gene expression. Nature Cell Biology 2010, 12: 758-767. PMID: 20622870, DOI: 10.1038/ncb2080.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBlotting, WesternCell LineCell Line, TumorChromatin ImmunoprecipitationChromatography, GelHeLa CellsHumansI-kappa B KinaseImmunohistochemistryImmunoprecipitationKaplan-Meier EstimateMiceNF-kappa BPhosphorylationPolymerase Chain ReactionProtein BindingRNA, Small InterferingShelterin ComplexTelomere-Binding ProteinsTissue Array Analysis
2003
Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of β-catenin, and enhanced tumor cell invasion
Lu Z, Ghosh S, Wang Z, Hunter T. Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of β-catenin, and enhanced tumor cell invasion. Cancer Cell 2003, 4: 499-515. PMID: 14706341, DOI: 10.1016/s1535-6108(03)00304-0.Peer-Reviewed Original ResearchMeSH KeywordsBeta CateninCadherinsCaveolaeCaveolin 1CaveolinsCell AdhesionCell MovementCell NucleusCytoskeletal ProteinsDNA-Binding ProteinsDown-RegulationEndocytosisEpidermal Growth FactorErbB ReceptorsGlycogen Synthase Kinase 3Glycogen Synthase Kinase 3 betaHumansIntercellular JunctionsNeoplasm MetastasisRNA, AntisenseSignal TransductionSnail Family Transcription FactorsTrans-ActivatorsTranscription FactorsTranscriptional ActivationTumor Cells, CulturedConceptsTranscriptional activityCaveolin-1Cell-cell adhesion proteinsCaveolin-1 functionCell-cell adhesionEGF receptor overexpressionE-cadherinCaveolin-dependent endocytosisTCF/LEFTranscriptional repressor SnailComplex cellular changesCaveolin-1 expressionChronic EGF treatmentTumor cell invasionEGF-induced effectsCaveolin-1 downregulationAdhesion proteinsNegative regulationTranscriptional downregulationAntisense RNAGSK-3betaE-cadherin expressionEGF treatmentHuman tumor cellsCell invasion