2015
Endosomal regulation of contact inhibition through the AMOT:YAP pathway
Cox CM, Mandell EK, Stewart L, Lu R, Johnson DL, McCarter SD, Tavares A, Runyan R, Ghosh S, Wilson JM. Endosomal regulation of contact inhibition through the AMOT:YAP pathway. Molecular Biology Of The Cell 2015, 26: 2673-2684. PMID: 25995376, PMCID: PMC4501364, DOI: 10.1091/mbc.e15-04-0224.Peer-Reviewed Original ResearchConceptsEndosomal membranesYAP activitySubconfluent cellsOrgan growth controlTranscription coactivator YesPhosphorylation-dependent regulationIntegral membrane proteinsConfluent cellsAmot proteinsEndosomal regulationContact-mediated inhibitionCytoplasmic domainEndotubinMembrane proteinsOvergrowth phenotypeInduces translocationAngiomotinYAP interactionDirect bindingGrowth controlContact inhibitionFamily membersCell growthYAPYAP pathway
2010
Telomere-independent Rap1 is an IKK adaptor and regulates NF-κB-dependent gene expression
Teo H, Ghosh S, Luesch H, Ghosh A, Wong ET, Malik N, Orth A, de Jesus P, Perry AS, Oliver JD, Tran NL, Speiser LJ, Wong M, Saez E, Schultz P, Chanda SK, Verma IM, Tergaonkar V. Telomere-independent Rap1 is an IKK adaptor and regulates NF-κB-dependent gene expression. Nature Cell Biology 2010, 12: 758-767. PMID: 20622870, DOI: 10.1038/ncb2080.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBlotting, WesternCell LineCell Line, TumorChromatin ImmunoprecipitationChromatography, GelHeLa CellsHumansI-kappa B KinaseImmunohistochemistryImmunoprecipitationKaplan-Meier EstimateMiceNF-kappa BPhosphorylationPolymerase Chain ReactionProtein BindingRNA, Small InterferingShelterin ComplexTelomere-Binding ProteinsTissue Array Analysis
2002
CK2 constitutively associates with and phosphorylates chicken erythroid ankyrin and regulates its ability to bind to spectrin
Ghosh S, Dorsey FC, Cox JV. CK2 constitutively associates with and phosphorylates chicken erythroid ankyrin and regulates its ability to bind to spectrin. Journal Of Cell Science 2002, 115: 4107-4115. PMID: 12356915, DOI: 10.1242/jcs.00102.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnkyrinsAntibody SpecificityCasein Kinase IICell MembraneChick EmbryoCytoskeletonDogsEnzyme InhibitorsEpithelial CellsErythroid Precursor CellsMacromolecular SubstancesPhosphoric Monoester HydrolasesPhosphorylationPhosphotransferasesPrecipitin TestsProtein BindingProtein IsoformsProtein Serine-Threonine KinasesSpectrinSubcellular FractionsConceptsErythroid ankyrinKidney epithelial cellsMadin-Darby canine kidney epithelial cellsCK2-specific inhibitorCanine kidney epithelial cellsEpithelial cellsPhosphorylation eventsPhosphatase inhibitorSpectrin cytoskeletonMembrane cytoskeletonPhosphorylation stateCK2Erythroid cellsAnkyrinCytoskeletonInhibitor studiesCell typesPhosphorylationSpectrinKinaseCellsFirst demonstrationVivoInhibitorsComplexes