2017
Erythrocyte efferocytosis modulates macrophages towards recovery after intracerebral hemorrhage
Chang CF, Goods BA, Askenase MH, Hammond MD, Renfroe SC, Steinschneider AF, Landreneau MJ, Ai Y, Beatty HE, da Costa LHA, Mack M, Sheth KN, Greer DM, Huttner A, Coman D, Hyder F, Ghosh S, Rothlin CV, Love JC, Sansing LH. Erythrocyte efferocytosis modulates macrophages towards recovery after intracerebral hemorrhage. Journal Of Clinical Investigation 2017, 128: 607-624. PMID: 29251628, PMCID: PMC5785262, DOI: 10.1172/jci95612.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisAxl Receptor Tyrosine KinaseBrain InjuriesCerebral HemorrhageC-Mer Tyrosine KinaseErythrocytesHematomaHumansImmunity, InnateInflammationMacrophagesMaleMiceMice, Inbred C57BLMice, TransgenicPhagocytosisPhenotypeProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesSolubilityTreatment OutcomeConceptsMonocyte-derived macrophagesIntracerebral hemorrhageEryptotic erythrocytesNeurological recoveryHematoma clearanceExperimental intracerebral hemorrhageReceptor tyrosine kinase AXLHuman monocyte-derived macrophagesTyrosine kinase AXLICH onsetFunctional outcomeBrain injuryTissue injurySoluble AxlDynamic phenotypic changesAlternative activationPhenotypic changesMacrophage phenotypeIron depositionMurine brainMacrophage responseRestorative functionEfferocytosisMacrophagesEngulfment of erythrocytes
2001
Dynamics of Ankyrin-containing Complexes in Chicken Embryonic Erythroid Cells: Role of Phosphorylation
Ghosh S, Cox J. Dynamics of Ankyrin-containing Complexes in Chicken Embryonic Erythroid Cells: Role of Phosphorylation. Molecular Biology Of The Cell 2001, 12: 3864-3874. PMID: 11739786, PMCID: PMC60761, DOI: 10.1091/mbc.12.12.3864.Peer-Reviewed Original ResearchConceptsCytoskeletal associationPhosphatase inhibitorErythroid ankyrinErythroid cellsEmbryonic erythroid cellsRole of phosphorylationAE1 anion exchangerTreatment of cellsBind spectrinAnkyrin isoformsAnkyrinCytoskeletal spectrinDynamic rearrangementPhosphorylationSoluble poolVivo consequencesSpectrinComplex formationSerineRapid cyclesIsoformsCellsPoolInhibitorsComplexes
1999
Chicken Erythroid AE1 Anion Exchangers Associate with the Cytoskeleton During Recycling to the Golgi
Ghosh S, Cox K, Cox J. Chicken Erythroid AE1 Anion Exchangers Associate with the Cytoskeleton During Recycling to the Golgi. Molecular Biology Of The Cell 1999, 10: 455-469. PMID: 9950688, PMCID: PMC25180, DOI: 10.1091/mbc.10.2.455.Peer-Reviewed Original ResearchAnimalsAnkyrinsAntiportersBiological Transport, ActiveBrefeldin ACell MembraneChick EmbryoChloride-Bicarbonate AntiportersCytoskeletonDetergentsErythroid Precursor CellsGolgi ApparatusIn Vitro TechniquesMannosyl-Glycoprotein Endo-beta-N-AcetylglucosaminidaseProtein Processing, Post-TranslationalSolubility