2013
ZIPping to Pain Relief: The Role (or Not) of PKMζ in Chronicc Pain
Price TJ, Ghosh S. ZIPping to Pain Relief: The Role (or Not) of PKMζ in Chronicc Pain. Molecular Pain 2013, 9: 1744-8069-9-6. PMID: 23433248, PMCID: PMC3621284, DOI: 10.1186/1744-8069-9-6.BooksMeSH KeywordsAnimalsCell-Penetrating PeptidesChronic PainEnzyme InhibitorsHumansLipopeptidesLong-Term PotentiationModels, BiologicalProtein Kinase CConceptsChronic pain statesChronic painLong-term potentiationAnterior cingulate cortexPain statesPain plasticityCertain chronic pain statesRole of PKMζSpinal dorsal hornChronic pain developmentSignificant clinical problemPotential roleSuch off-target effectsPain reliefDorsal hornPain developmentCNS areasCNS regionsClinical problemNociceptor stimulationPainCingulate cortexNew targetsKey moleculesOff-target effects
2002
CK2 constitutively associates with and phosphorylates chicken erythroid ankyrin and regulates its ability to bind to spectrin
Ghosh S, Dorsey FC, Cox JV. CK2 constitutively associates with and phosphorylates chicken erythroid ankyrin and regulates its ability to bind to spectrin. Journal Of Cell Science 2002, 115: 4107-4115. PMID: 12356915, DOI: 10.1242/jcs.00102.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnkyrinsAntibody SpecificityCasein Kinase IICell MembraneChick EmbryoCytoskeletonDogsEnzyme InhibitorsEpithelial CellsErythroid Precursor CellsMacromolecular SubstancesPhosphoric Monoester HydrolasesPhosphorylationPhosphotransferasesPrecipitin TestsProtein BindingProtein IsoformsProtein Serine-Threonine KinasesSpectrinSubcellular FractionsConceptsErythroid ankyrinKidney epithelial cellsMadin-Darby canine kidney epithelial cellsCK2-specific inhibitorCanine kidney epithelial cellsEpithelial cellsPhosphorylation eventsPhosphatase inhibitorSpectrin cytoskeletonMembrane cytoskeletonPhosphorylation stateCK2Erythroid cellsAnkyrinCytoskeletonInhibitor studiesCell typesPhosphorylationSpectrinKinaseCellsFirst demonstrationVivoInhibitorsComplexes
2001
Dynamics of Ankyrin-containing Complexes in Chicken Embryonic Erythroid Cells: Role of Phosphorylation
Ghosh S, Cox J. Dynamics of Ankyrin-containing Complexes in Chicken Embryonic Erythroid Cells: Role of Phosphorylation. Molecular Biology Of The Cell 2001, 12: 3864-3874. PMID: 11739786, PMCID: PMC60761, DOI: 10.1091/mbc.12.12.3864.Peer-Reviewed Original ResearchConceptsCytoskeletal associationPhosphatase inhibitorErythroid ankyrinErythroid cellsEmbryonic erythroid cellsRole of phosphorylationAE1 anion exchangerTreatment of cellsBind spectrinAnkyrin isoformsAnkyrinCytoskeletal spectrinDynamic rearrangementPhosphorylationSoluble poolVivo consequencesSpectrinComplex formationSerineRapid cyclesIsoformsCellsPoolInhibitorsComplexes