MHC Class I–Associated Phosphopeptides Are the Targets of Memory-like Immunity in Leukemia
Cobbold M, De La Peña H, Norris A, Polefrone JM, Qian J, English AM, Cummings KL, Penny S, Turner JE, Cottine J, Abelin JG, Malaker SA, Zarling AL, Huang HW, Goodyear O, Freeman SD, Shabanowitz J, Pratt G, Craddock C, Williams ME, Hunt DF, Engelhard VH. MHC Class I–Associated Phosphopeptides Are the Targets of Memory-like Immunity in Leukemia. Science Translational Medicine 2013, 5: 203ra125. PMID: 24048523, PMCID: PMC4071620, DOI: 10.1126/scitranslmed.3006061.Peer-Reviewed Original ResearchConceptsT cellsImmune surveillanceAllogeneic stem cell transplantationMajor histocompatibility complex class IStem cell transplantationT cell responsesHistocompatibility complex class IAdoptive transfer immunotherapyCancer immune surveillanceHuman leukocyte antigenComplex class ICell linesPrimary leukemia cellsT cell linesClinical outcomesCell transplantationLeukocyte antigenLeukemia patientsMemory compartmentHematological tumorsHealthy individualsLeukemia cell linesCell responsesMalignant transformationNormal tissues