Analysis of the clinical safety of intralesional injection of collagenase Clostridium histolyticum (CCH) for adults with Peyronie's disease (PD)
Carson CC, Sadeghi-Nejad H, Tursi JP, Smith TM, Kaufman GJ, Gilbert K, Honig SC. Analysis of the clinical safety of intralesional injection of collagenase Clostridium histolyticum (CCH) for adults with Peyronie's disease (PD). BJU International 2015, 116: 815-822. PMID: 25818264, DOI: 10.1111/bju.13120.Peer-Reviewed Original ResearchConceptsTreatment-related adverse eventsCollagenase clostridium histolyticumPooled safety analysisAdverse eventsSerious AEsPeyronie's diseasePenile haematomaIntralesional injectionClinical studiesSerious treatment-related adverse eventsTreatment-emergent adverse eventsTreatment-related serious AEsOpen-label safetyPlacebo-controlled studySerious adverse eventsSystemic hypersensitivity reactionClostridium histolyticumCorporal ruptureHypersensitivity eventsPenile painMost patientsPenile swellingAntibody levelsCCH treatmentHypersensitivity reactions