2022
Two-Year Analysis of a New Oral Testosterone Undecanoate (TU) Formulation in Hypogonadal Men: Efficacy, Impact on Psychosexual Function, and Safety.
Honig S, Gittelman M, Kaminetsky J, Wang C, Amory J, Rohowsky N, Dudley R, Woun Seo B, Newmark J, Swerdloff R. Two-Year Analysis of a New Oral Testosterone Undecanoate (TU) Formulation in Hypogonadal Men: Efficacy, Impact on Psychosexual Function, and Safety. The Journal Of Sexual Medicine 2022, 19: 1750-1758. PMID: 37057401, DOI: 10.1016/j.jsxm.2022.09.002.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedHumansHypogonadismLibidoMaleMiddle AgedSexual BehaviorTestosteroneYoung AdultConceptsTestosterone replacement therapyPsychosexual Daily QuestionnaireLiver function testsOral TUSerum T concentrationsSexual functionT concentrationsTU therapyHypogonadal menFunction testsEffective long-term treatment optionProstate-specific antigen levelHigh-density lipoprotein cholesterolLong-term treatment optionAdult hypogonadal menOral testosterone undecanoateTotal testosterone levelsSystolic blood pressureTotal T concentrationsActive-controlled trialYears of treatmentLong-term safetySignificant changesEugonadal rangeCardiovascular endpoints
2019
Multicenter Investigation of Fungal Infections of Inflatable Penile Prostheses
Gross MS, Reinstatler L, Henry GD, Honig SC, Stahl PJ, Burnett AL, Maria PP, Bennett NE, Kava BR, Kohler TS, Beilan JA, Carrion RE, Munarriz RM. Multicenter Investigation of Fungal Infections of Inflatable Penile Prostheses. The Journal Of Sexual Medicine 2019, 16: 1100-1105. PMID: 31255212, DOI: 10.1016/j.jsxm.2019.05.003.Peer-Reviewed Original ResearchConceptsInflatable penile prosthesisPenile prosthesisFungal infectionsIPP infectionAntifungal prophylaxisIPP implantationDiabetic patientsMulticenter investigationCurrent American Urological Association guidelinesMean body mass indexAmerican Urological Association guidelinesRetrospective institutional review boardExtensive record reviewMulti-institution databaseRecent antibiotic exposurePiperacillin/tazobactamBody mass indexAmpicillin/sulbactamPercent of implantsSecond-generation cephalosporinsPenile prosthesis infectionInstitutional review boardIntravenous antibioticsMean hemoglobinOverweight patients
2016
Trends in Testosterone Replacement Therapy Use from 2003 to 2013 among Reproductive-Age Men in the United States
Rao PK, Boulet SL, Mehta A, Hotaling J, Eisenberg ML, Honig SC, Warner L, Kissin DM, Nangia AK, Ross LS. Trends in Testosterone Replacement Therapy Use from 2003 to 2013 among Reproductive-Age Men in the United States. Journal Of Urology 2016, 197: 1121-1126. PMID: 27789218, PMCID: PMC11056957, DOI: 10.1016/j.juro.2016.10.063.Peer-Reviewed Original ResearchConceptsTherapy useReproductive-age menTherapy usersMen 18Older menTestosterone replacement therapyTruven Health MarketScanLong-term sequelaeCommercial claims databaseYounger age groupsCochran-Armitage testCross-sectional analysisFourfold increaseMen 56Topical gel formulationTestosterone useClaims databaseReplacement therapySignificant threefold increaseInjection usePractice patternsGel usePoisson regressionAge groupsSemen analysis
2015
Analysis of the clinical safety of intralesional injection of collagenase Clostridium histolyticum (CCH) for adults with Peyronie's disease (PD)
Carson CC, Sadeghi-Nejad H, Tursi JP, Smith TM, Kaufman GJ, Gilbert K, Honig SC. Analysis of the clinical safety of intralesional injection of collagenase Clostridium histolyticum (CCH) for adults with Peyronie's disease (PD). BJU International 2015, 116: 815-822. PMID: 25818264, DOI: 10.1111/bju.13120.Peer-Reviewed Original ResearchConceptsTreatment-related adverse eventsCollagenase clostridium histolyticumPooled safety analysisAdverse eventsSerious AEsPeyronie's diseasePenile haematomaIntralesional injectionClinical studiesSerious treatment-related adverse eventsTreatment-emergent adverse eventsTreatment-related serious AEsOpen-label safetyPlacebo-controlled studySerious adverse eventsSystemic hypersensitivity reactionClostridium histolyticumCorporal ruptureHypersensitivity eventsPenile painMost patientsPenile swellingAntibody levelsCCH treatmentHypersensitivity reactions
2008
The expression and distribution of deoxyribonucleic acid repair and apoptosis markers in testicular germ cells of infertile varicocele patients resembles that of old fertile men
El-Domyati MM, Al-Din AB, Barakat MT, El-Fakahany HM, Honig S, Xu J, Sakkas D. The expression and distribution of deoxyribonucleic acid repair and apoptosis markers in testicular germ cells of infertile varicocele patients resembles that of old fertile men. Fertility And Sterility 2008, 93: 795-801. PMID: 19062002, DOI: 10.1016/j.fertnstert.2008.10.031.Peer-Reviewed Original ResearchConceptsInfertile varicocele patientsDNA repair markersVaricocele patientsFertile menTesticular germ cellsApoptosis markersRetrospective case-control studyRepair markersHuman testicular germ cellsCase-control studyCell proliferation markersApoptosis marker proteinsGerm cellsTesticular specimensImmunohistochemical stainingMAIN OUTCOMEFertile volunteersInfertile menPatientsProliferation markersAbove markersDeoxyribonucleic acid repairTesticular tissueYoung menMen
2006
Single-Blind, Multicenter, Placebo Controlled, Parallel Study to Assess the Safety and Efficacy of Intralesional Interferon α-2b for Minimally Invasive Treatment for Peyronie’s Disease
Hellstrom WJ, Kendirci M, Matern R, Cockerham Y, Myers L, Sikka SC, Venable D, Honig S, McCullough A, Hakim LS, Nehra A, Templeton LE, Pryor JL. Single-Blind, Multicenter, Placebo Controlled, Parallel Study to Assess the Safety and Efficacy of Intralesional Interferon α-2b for Minimally Invasive Treatment for Peyronie’s Disease. Journal Of Urology 2006, 176: 394-398. PMID: 16753449, DOI: 10.1016/s0022-5347(06)00517-9.Peer-Reviewed Original ResearchConceptsIntralesional interferon alpha-2bAlpha-2bInterferon alpha-2bPeyronie's diseasePenile curvatureInterferon alpha-2b therapyPlaque sizeAlpha-2b therapyIntralesional interferon αMean International IndexErectile Function scoreFlu-like symptomsBlood flow improvementParallel studyPenile painPlacebo-ControlledPain resolutionConsecutive patientsErectile functionFunction scoresMean ageControl armInternational IndexInvasive treatmentStudy completion
2003
Microarray Gene Analysis and Expression Profiles of Dupuytren’s Contracture
Pan D, Watson HK, Swigart C, Thomson JG, Honig SC, Narayan D. Microarray Gene Analysis and Expression Profiles of Dupuytren’s Contracture. Annals Of Plastic Surgery 2003, 50: 618-622. PMID: 12783014, DOI: 10.1097/01.sap.0000069066.35253.b3.Peer-Reviewed Original ResearchAgedBase SequenceCohort StudiesDNA PrimersDupuytren ContractureFemaleGene Expression RegulationGenetic Predisposition to DiseaseHumansMaleMiddle AgedMolecular Sequence DataOligonucleotide Array Sequence AnalysisReverse Transcriptase Polymerase Chain ReactionSampling StudiesSensitivity and Specificity
1997
The prevalence of cystic abnormalities of the prostate involving the ejaculatory ducts as detected by transrectal ultrasound
Kim E, Onel E, Honig S, Lipshultz L. The prevalence of cystic abnormalities of the prostate involving the ejaculatory ducts as detected by transrectal ultrasound. International Urology And Nephrology 1997, 29: 647-652. PMID: 9477362, DOI: 10.1007/bf02552181.Peer-Reviewed Original ResearchConceptsCystic lesionsTransrectal ultrasoundInfertile menEjaculatory ductPopulation of menScreening groupDuctal obstructionMethodsThe prevalencePrevalence increasesProstate cancerCystic abnormalitiesLarge seriesLesionsProstateSemen analysisPrevalenceFertile malesDuctMenAbnormalitiesRiskUltrasoundPopulationPurposeToInfertility
1992
The role of fine‐needle aspiration biopsy of the prostate in staging adenocarcinoma
Honig S, Stilmant M, Klavans M, Freedlund M, Siroky M. The role of fine‐needle aspiration biopsy of the prostate in staging adenocarcinoma. Cancer 1992, 69: 2978-2982. PMID: 1591691, DOI: 10.1002/1097-0142(19920615)69:12<2978::aid-cncr2820691219>3.0.co;2-z.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAgedAged, 80 and overBiopsy, NeedleHumansMaleMiddle AgedNeoplasm StagingProstatic NeoplasmsConceptsMalignant cytologic findingsFine-needle aspiration biopsyStage A1 diseaseCytologic findingsProstate cancerStage A1A2 diseaseTURP specimenAspiration biopsyIncidental prostate cancerModerate-grade tumorsStage A2 diseaseTherapy of patientsHigh-grade tumorsClinical suspicionOutlet obstructionConsecutive patientsTransurethral resectionBetter prognosisHistologic evidenceGrade tumorsHistologic findingsRadical prostatectomyIncidental findingStage A2