2023
Activity‐based Tools for Interrogating Host Biology During Infection
Ramanathan R, Hatzios S. Activity‐based Tools for Interrogating Host Biology During Infection. Israel Journal Of Chemistry 2023, 63 PMID: 37744997, PMCID: PMC10512441, DOI: 10.1002/ijch.202200095.Peer-Reviewed Original ResearchActivity-based protein profilingPost-translational modificationsHost post-translational modificationsHost-microbe interactionsHost biologyCells senseCell signalingMicrobial mechanismsEnzyme functionProtein profilingProtein structureSide-chain reactivityChemical probesInfected cellsHost-directed therapiesPotential targetRapid modulationHost responseSignalingBiologyInfectionEnzymeProfilingPathwayPathogens
2022
An infection-induced oxidation site regulates legumain processing and tumor growth
Kovalyova Y, Bak DW, Gordon EM, Fung C, Shuman JHB, Cover TL, Amieva MR, Weerapana E, Hatzios SK. An infection-induced oxidation site regulates legumain processing and tumor growth. Nature Chemical Biology 2022, 18: 698-705. PMID: 35332331, PMCID: PMC9246868, DOI: 10.1038/s41589-022-00992-x.Peer-Reviewed Original ResearchConceptsCysteine reactivityOxidation sitesTumor growthChemical proteomicsH. pylori-infected cellsRedox-sensitive cysteinesInduces oxidationReactivityOxidationOxidation EventHuman gastric cellsCarcinogenic infectionsBacterium Helicobacter pyloriXenograft modelHelicobacter pyloriSite-specific lossGastric cellsMost cancersOxidative stressReactive oxygen speciesTumor formationOxygen speciesInfectionTumorigenesisCysteine
2016
Chemoproteomic profiling of host and pathogen enzymes active in cholera
Hatzios SK, Abel S, Martell J, Hubbard T, Sasabe J, Munera D, Clark L, Bachovchin DA, Qadri F, Ryan ET, Davis BM, Weerapana E, Waldor MK. Chemoproteomic profiling of host and pathogen enzymes active in cholera. Nature Chemical Biology 2016, 12: 268-274. PMID: 26900865, PMCID: PMC4765928, DOI: 10.1038/nchembio.2025.Peer-Reviewed Original Research