2023
Activity‐based Tools for Interrogating Host Biology During Infection
Ramanathan R, Hatzios S. Activity‐based Tools for Interrogating Host Biology During Infection. Israel Journal Of Chemistry 2023, 63 PMID: 37744997, PMCID: PMC10512441, DOI: 10.1002/ijch.202200095.Peer-Reviewed Original ResearchActivity-based protein profilingPost-translational modificationsHost post-translational modificationsHost-microbe interactionsHost biologyCells senseCell signalingMicrobial mechanismsEnzyme functionProtein profilingProtein structureSide-chain reactivityChemical probesInfected cellsHost-directed therapiesPotential targetRapid modulationHost responseSignalingBiologyInfectionEnzymeProfilingPathwayPathogens
2013
Osmosensory signaling in Mycobacterium tuberculosis mediated by a eukaryotic-like Ser/Thr protein kinase
Hatzios SK, Baer CE, Rustad TR, Siegrist MS, Pang JM, Ortega C, Alber T, Grundner C, Sherman DR, Bertozzi CR. Osmosensory signaling in Mycobacterium tuberculosis mediated by a eukaryotic-like Ser/Thr protein kinase. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: e5069-e5077. PMID: 24309377, PMCID: PMC3876250, DOI: 10.1073/pnas.1321205110.Peer-Reviewed Original ResearchConceptsEukaryotic-like Ser/Thr protein kinasesSer/Thr protein kinaseOsmotic stressProtein kinaseCell wall remodelingAlternative σ factorsVirulence factor productionΣ factorsTranscriptional programsSecretion systemESX-1 secretion systemBroader roleWall remodelingWidespread occurrenceKinaseBacteriaPhysiological changesFactor productionPathwayDifferent microenvironmentsAntibiotic resistanceOsmosensingRegulonPknDMycobacterium tuberculosis