2009
Adult combination antiretroviral therapy in sub-Saharan Africa: lessons from Botswana and future challenges
Wester CW, Bussmann H, Koethe J, Moffat C, Vermund S, Essex M, Marlink RG. Adult combination antiretroviral therapy in sub-Saharan Africa: lessons from Botswana and future challenges. HIV Therapy 2009, 3: 501-526. PMID: 20161344, PMCID: PMC2774911, DOI: 10.2217/hiv.09.35.Peer-Reviewed Original ResearchCombination antiretroviral therapyAntiretroviral therapyUse of cARTFirst-line combination antiretroviral therapyHIV-1-infected adultsPrimary HIV-1 infectionMonths of treatmentHIV-1 infectionResource-rich settingsHigh mortality rateImmunologic recoveryVirologic suppressionHIV infectionHealthcare utilizationSaharan AfricaAdherence ratesLifelong monitoringPROGRESS trialTreatment outcomesMortality rateCART programClinical servicesImpressive declineTherapyInfection
2008
Predictors of Adherence to Antiretroviral Therapy in Rural Zambia
Carlucci JG, Kamanga A, Sheneberger R, Shepherd BE, Jenkins CA, Spurrier J, Vermund SH. Predictors of Adherence to Antiretroviral Therapy in Rural Zambia. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2008, 47: 615-622. PMID: 18209678, PMCID: PMC2743102, DOI: 10.1097/qai.0b013e318165dc25.Peer-Reviewed Original ResearchConceptsRural health facilitiesHIV/AIDS careRural ZambiaBetter clinical outcomesBody mass indexHIV drug resistancePredictors of adherenceResource-limited settingsAntiretroviral therapyAIDS stagePatient demographicsPill countPharmacy recordsClinical outcomesMass indexAdherence ratesClinical indicesAIDS careAdherence levelsHealth facilitiesOptimize outcomesPatient's homeMission hospitalPatientsStudy participants
2004
Universal nevirapine upon presentation in labor to prevent mother-to-child HIV transmission in high prevalence settings
Stringer J, Sinkala M, Goldenberg RL, Kumwenda R, Acosta EP, Aldrovandi GM, Stout JP, Vermund SH. Universal nevirapine upon presentation in labor to prevent mother-to-child HIV transmission in high prevalence settings. AIDS 2004, 18: 939-943. PMID: 15060442, PMCID: PMC2745979, DOI: 10.1097/00002030-200404090-00012.Peer-Reviewed Original ResearchConceptsChild HIV transmissionUnknown HIV serostatusHIV serostatusHIV transmissionPreliminary efficacyLabour wardHIV DNA polymerase chain reactionSingle-dose nevirapinePrevention of motherProspective cohort studyEvidence of infectionHigh-prevalence settingsWeeks of lifeNevirapine administrationNevirapine coverageChild transmissionCohort studyComparison cohortAdherence ratesPrevalence settingsPolymerase chain reactionCord bloodDNA polymerase chain reactionHIVInfant specimens