2007
Early clinical and immune response to NNRTI-based antiretroviral therapy among women with prior exposure to single-dose nevirapine
Chi BH, Sinkala M, Stringer EM, Cantrell RA, Mtonga V, Bulterys M, Zulu I, Kankasa C, Wilfert C, Weidle PJ, Vermund SH, Stringer J. Early clinical and immune response to NNRTI-based antiretroviral therapy among women with prior exposure to single-dose nevirapine. AIDS 2007, 21: 957-964. PMID: 17457089, PMCID: PMC2745970, DOI: 10.1097/qad.0b013e32810996b2.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveCD4 Lymphocyte CountDrug Administration ScheduleEpidemiologic MethodsFemaleHIV InfectionsHumansInfectious Disease Transmission, VerticalNevirapinePregnancyPregnancy Complications, InfectiousReverse Transcriptase InhibitorsTreatment FailureTreatment OutcomeConceptsSingle-dose nevirapineClinical treatment failureCD4 cell responseAntiretroviral therapyTreatment failureNVP exposureTreatment outcomesCell responsesShort-term treatment outcomesPrior exposureChild HIV transmissionPrevention of motherCD4 cell changesPoor treatment outcomesNon-nucleoside reverseSignificant differencesWorld Health Organization guidelinesHealth Organization guidelinesART initiationCohort evaluationMultivariable analysisHIV transmissionHIV treatmentRisk factorsImmune response
2002
Correlates of Nontransmission in US Women at High Risk of Human Immunodeficiency Virus Type 1 Infection through Sexual Exposure
Skurnick JH, Palumbo P, DeVico A, Shacklett BL, Valentine FT, Merges M, Kamin-Lewis R, Mestecky J, Denny T, Lewis GK, Lloyd J, Praschunus R, Baker A, Nixon DF, Stranford S, Gallo R, Vermund SH, Louria DB. Correlates of Nontransmission in US Women at High Risk of Human Immunodeficiency Virus Type 1 Infection through Sexual Exposure. The Journal Of Infectious Diseases 2002, 185: 428-438. PMID: 11865394, PMCID: PMC2743095, DOI: 10.1086/338830.Peer-Reviewed Original ResearchConceptsSexual exposureSuppressive activityHuman immunodeficiency virus type 1 (HIV-1) infectionHigher CD8 cell countsHIV-1-suppressive activitySingle-cell cytokine productionHuman immunodeficiency virus type 1Macrophage inflammatory protein-1 betaVirus type 1 infectionHIV-positive male partnersInflammatory protein-1 betaMale partnersImmunodeficiency virus type 1CD4 cell responseCD8 cell countsHIV-positive donorsHIV-positive partnerHIV-negative partnersType 1 infectionInterferon-gamma secretionHIV-suppressive activityVirus type 1Apparent protective roleHIV antigenLocal antibodies