2015
Implementation and Operational Research
Kapambwe S, Sahasrabuddhe VV, Blevins M, Mwanahamuntu MH, Mudenda V, Shepherd BE, Chibwesha CJ, Pfaendler KS, Hicks ML, Vermund SH, Stringer JS, Parham GP. Implementation and Operational Research. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2015, 70: e20-e26. PMID: 26322673, PMCID: PMC4791059, DOI: 10.1097/qai.0000000000000685.Peer-Reviewed Original ResearchConceptsUnknown HIV serostatusHIV serostatusYoung womenCervical cancerOlder womenHIV/AIDS care programsCervical cancer prevention programsInvasive cervical cancer casesRisk of ICCHIV-seronegative womenHIV-seropositive womenIndependent risk factorCancer prevention programsCervical cancer casesMultivariable logistic regressionAIDS care programsLifetime sexual partnersHIV infectionSaharan AfricaRisk factorsCancer casesAge 35High riskICC casesCare programPopulation-Level Scale-Up of Cervical Cancer Prevention Services in a Low-Resource Setting: Development, Implementation, and Evaluation of the Cervical Cancer Prevention Program in Zambia
Parham GP, Mwanahamuntu MH, Kapambwe S, Muwonge R, Bateman AC, Blevins M, Chibwesha CJ, Pfaendler KS, Mudenda V, Shibemba AL, Chisele S, Mkumba G, Vwalika B, Hicks ML, Vermund SH, H. BH, Stringer JS, Sankaranarayanan R, Sahasrabuddhe VV. Population-Level Scale-Up of Cervical Cancer Prevention Services in a Low-Resource Setting: Development, Implementation, and Evaluation of the Cervical Cancer Prevention Program in Zambia. PLOS ONE 2015, 10: e0122169. PMID: 25885821, PMCID: PMC4401717, DOI: 10.1371/journal.pone.0122169.Peer-Reviewed Original ResearchConceptsCervical cancer prevention programsCancer prevention programsHistopathologic evaluationCervical intraepithelial neoplasia grade 2Cervical cancer prevention servicesPrevention programsHIV-negative womenInvasive cervical cancerCancer prevention servicesCervical cancer preventionExpert physician opinionHIV/AIDS programsElectronic medical recordsLow-resource countriesProportion of womenSame-day servicesLow-resource settingsUnscreened womenEvaluable dataCervical diseaseCervical cancerScreening servicesMedical recordsCancer preventionCervical precancer
2013
Utilization of Cervical Cancer Screening Services and Trends in Screening Positivity Rates in a ‘Screen-And-Treat’ Program Integrated with HIV/AIDS Care in Zambia
Mwanahamuntu MH, Sahasrabuddhe VV, Blevins M, Kapambwe S, Shepherd BE, Chibwesha C, Pfaendler KS, Mkumba G, Vwalika B, Hicks ML, Vermund SH, Stringer JS, Parham GP. Utilization of Cervical Cancer Screening Services and Trends in Screening Positivity Rates in a ‘Screen-And-Treat’ Program Integrated with HIV/AIDS Care in Zambia. PLOS ONE 2013, 8: e74607. PMID: 24058599, PMCID: PMC3776830, DOI: 10.1371/journal.pone.0074607.Peer-Reviewed Original ResearchConceptsCervical cancer screening servicesCancer screening servicesHIV-seronegative womenHIV serostatusScreening servicesHIV/AIDS care programsCervical cancer prevention programsCervical cancer prevention servicesCervical cancer screening programsHIV/AIDS careHIV-seropositive womenCancer prevention servicesCancer prevention programsCancer screening programsAIDS care programsProportion of womenPatterns of utilizationHIV-seropositiveCervical cancerSaharan AfricaTest positivityPositivity rateAIDS careScreening programMultivariable modeling
2012
HPV Genotype Distribution in Cervical Intraepithelial Neoplasia among HIV-Infected Women in Pune, India
Mane A, Nirmalkar A, Risbud AR, Vermund SH, Mehendale SM, Sahasrabuddhe VV. HPV Genotype Distribution in Cervical Intraepithelial Neoplasia among HIV-Infected Women in Pune, India. PLOS ONE 2012, 7: e38731. PMID: 22723879, PMCID: PMC3378535, DOI: 10.1371/journal.pone.0038731.Peer-Reviewed Original ResearchConceptsCarcinogenic HPV genotypesHPV genotypesLow CD4HPV infectionCIN3 lesionsCommon HPV genotypesHPV genotype distributionMultiple HPV genotypesCombination antiretroviral therapyCervical intraepithelial neoplasiaCarcinogenic HPV infectionHalf of womenQuarter of womenHPV type detectionLifetime sexual partnersCarcinogenic HPVHPV16 detectionAntiretroviral therapyHPV genotypingComposite endpointOrder of prevalenceIntraepithelial neoplasiaCervical cancerHPV 16Observational studyImplementation of cervical cancer screening using visual inspection with acetic acid in rural Mozambique: successes and challenges using HIV care and treatment programme investments in Zambézia Province
Moon TD, Silva‐Matos C, Cordoso A, Baptista AJ, Sidat M, Vermund SH. Implementation of cervical cancer screening using visual inspection with acetic acid in rural Mozambique: successes and challenges using HIV care and treatment programme investments in Zambézia Province. Journal Of The International AIDS Society 2012, 15: 17406. PMID: 22713260, PMCID: PMC3499800, DOI: 10.7448/ias.15.2.17406.Peer-Reviewed Original ResearchConceptsLoop electrosurgical excision procedureHIV careCervical cancerProvincial HospitalZambézia ProvinceCervical cancer screening servicesMaternal child health nursesAntiretroviral therapy rolloutVIA-positive womenCancer screening servicesElectrosurgical excision procedureChild health nursesSquamous intraepithelial lesionsCervical cancer screeningChronic disease screeningHealth manpower shortagesRural MozambiqueExcision procedureHIV testingIntraepithelial lesionsHIV statusClinic nursesScreening servicesCancer screeningHealth nursesCervical Cancer Prevention in Low- and Middle-Income Countries: Feasible, Affordable, Essential
Sahasrabuddhe VV, Parham GP, Mwanahamuntu MH, Vermund SH. Cervical Cancer Prevention in Low- and Middle-Income Countries: Feasible, Affordable, Essential. Cancer Prevention Research 2012, 5: 11-17. PMID: 22158053, PMCID: PMC3586242, DOI: 10.1158/1940-6207.capr-11-0540.Peer-Reviewed Original ResearchConceptsCervical cancer preventionHuman immunodeficiency virusCervical cancerMiddle-income countriesCancer preventionPrevention servicesCervical cancer prevention servicesCancer prevention servicesCervical cancer screeningGynecologic issuesImmunodeficiency virusHuman papillomavirusCancer screeningEarly treatmentPelvic examHigh-income countriesWorldwide burdenCare deliveryNew casesScreening testHPVCancerLMICsEffective alternativePrevention
2011
Comparison of visual inspection with acetic acid and cervical cytology to detect high‐grade cervical neoplasia among HIV‐infected women in India
Sahasrabuddhe VV, Bhosale RA, Kavatkar AN, Nagwanshi CA, Joshi SN, Jenkins CA, Shepherd BE, Kelkar RS, Sahay S, Risbud AR, Vermund SH, Mehendale SM. Comparison of visual inspection with acetic acid and cervical cytology to detect high‐grade cervical neoplasia among HIV‐infected women in India. International Journal Of Cancer 2011, 130: 234-240. PMID: 21387289, PMCID: PMC3516675, DOI: 10.1002/ijc.25971.Peer-Reviewed Original ResearchMeSH KeywordsAcetatesAdultCervix UteriColposcopyCross-Sectional StudiesCytodiagnosisDNA, ViralFemaleHIVHIV InfectionsHumansIndiaMass ScreeningPapanicolaou TestPolymerase Chain ReactionPredictive Value of TestsSensitivity and SpecificityUterine Cervical DysplasiaUterine Cervical NeoplasmsVaginal SmearsConceptsCervical cytologyHigh-grade squamous intraepithelial lesionsHigh-grade cervical neoplasiaNegative predictive value estimatesScreening testHPV-positive CIN2Atypical squamous cellsSquamous intraepithelial lesionsHuman immunodeficiency virusConventional cervical cytologyPredictive value estimatesSecondary prevention methodsNonpregnant HIVRigorous endpointsAntiretroviral therapyHIV/Intraepithelial lesionsCervical neoplasiaCervical cancerImmunodeficiency virusSquamous cellsHuman papillomavirusUndetermined significanceIntraepithelial cellsCare program
2010
Implementation of cervical cancer prevention services for HIV-infected women in Zambia: measuring program effectiveness
Parham GP, Mwanahamuntu MH, Sahasrabuddhe VV, Westfall AO, King KE, Chibwesha C, Pfaendler KS, Mkumba G, Mudenda V, Kapambwe S, Vermund SH, Hicks ML, Stringer JS, Chi BH. Implementation of cervical cancer prevention services for HIV-infected women in Zambia: measuring program effectiveness. HIV Therapy 2010, 4: 713-722. PMID: 25419240, PMCID: PMC4237284, DOI: 10.2217/hiv.10.52.Peer-Reviewed Original ResearchCervical cancer deathsCervical cancer prevention programsCancer prevention programsCervical cancerCancer deathHistologic evaluationHIV/AIDS care programsVisible lesionsCervical cancer prevention methodsCervical cancer prevention servicesPrevention programsCervical intraepithelial neoplasia (CIN) IPrevention effortsCancer prevention servicesCancer prevention methodsIntraepithelial neoplasia IAIDS care programsFuture prevention effortsCIN 2/3Clinical outcomesClinical managementProgram effectivenessPrevention servicesHIVCare programPrevalence and Predictors of Colposcopic-Histopathologically Confirmed Cervical Intraepithelial Neoplasia in HIV-Infected Women in India
Sahasrabuddhe VV, Bhosale RA, Joshi SN, Kavatkar AN, Nagwanshi CA, Kelkar RS, Jenkins CA, Shepherd BE, Sahay S, Risbud AR, Vermund SH, Mehendale SM. Prevalence and Predictors of Colposcopic-Histopathologically Confirmed Cervical Intraepithelial Neoplasia in HIV-Infected Women in India. PLOS ONE 2010, 5: e8634. PMID: 20072610, PMCID: PMC2798747, DOI: 10.1371/journal.pone.0008634.Peer-Reviewed Original ResearchConceptsCervical intraepithelial neoplasiaCervical high-risk HPV DNASeverity of CINHigh-risk HPV DNAAntiretroviral therapyHPV DNAIndependent predictorsIntraepithelial neoplasiaCervical cancerEvidence of CINPrevalence of CINPrevalence estimatesMultivariable ordinal logistic regression analysisMultivariable ordinal logistic regressionAdvanced neoplastic diseaseNon-pregnant HIVTrue disease burdenCervical precancerous lesionsLogistic regression analysisOrdinal logistic regression analysisClinical suspicionCIN1 lesionsMedian agePreventable cancersCervical cytology
2009
Human Immunodeficiency Virus (HIV) Antigens and RNA in HIV-Seronegative Women with Cervical Intraepithelial Neoplasia
Basu J, Romney SL, Angeletti RH, Vermund SH, Nieves E, Kadish AS, Mikhail MS, Orr GA. Human Immunodeficiency Virus (HIV) Antigens and RNA in HIV-Seronegative Women with Cervical Intraepithelial Neoplasia. AIDS Research And Human Retroviruses 2009, 25: 249-259. PMID: 19292595, PMCID: PMC6463994, DOI: 10.1089/aid.2008.0096.Peer-Reviewed Original ResearchConceptsCervical intraepithelial neoplasiaProstate-specific antigenCervicovaginal lavageHIV proteinsIntraepithelial neoplasiaWestern blotHuman immunodeficiency virus antigenHIV p24 expressionHIV-2 antibodiesHIV-seronegative womenRisk of progressionViral load assaysCervical biopsy specimensHIV serologySeronegative womenHIV RNAHIV exposureCervical secretionsHIV antigenNegative serologyP24 antigenCervical cancerBiopsy specimensP24 expressionVirus antigen
2006
Prevalence and predictors of squamous intraepithelial lesions of the cervix in HIV-infected women in Lusaka, Zambia
Parham GP, Sahasrabuddhe VV, Mwanahamuntu MH, Shepherd BE, Hicks ML, Stringer EM, Vermund SH. Prevalence and predictors of squamous intraepithelial lesions of the cervix in HIV-infected women in Lusaka, Zambia. Gynecologic Oncology 2006, 103: 1017-1022. PMID: 16875716, PMCID: PMC2748907, DOI: 10.1016/j.ygyno.2006.06.015.Peer-Reviewed Original ResearchConceptsHigh-risk HPV typesSquamous intraepithelial lesionsSquamous cell carcinomaHPV typesIntraepithelial lesionsHIV/AIDS care servicesPrevalence of SILHigh-grade squamous intraepithelial lesionsLow-grade squamous intraepithelial lesionsCervical squamous intraepithelial lesionsMultivariable logistic regression modelingNon-pregnant HIVScreening of HIVDevelopment of HPVLogistic regression modelingResource-constrained settingsResource-constrained nationsMedian CD4Abnormal cytologyAntiretroviral therapyCytological lesionsHPV typingIndependent predictorsMedian ageCervical cancer
2003
Utility of cervicography in HIV-infected and uninfected adolescents
Moscicki AB, Durako SJ, Ma Y, Darragh T, Vermund SH. Utility of cervicography in HIV-infected and uninfected adolescents. Journal Of Adolescent Health 2003, 32: 204-213. PMID: 12606114, DOI: 10.1016/s1054-139x(02)00461-5.Peer-Reviewed Original ResearchConceptsPositive predictive valuePap smearUninfected groupHigh-risk adolescent populationAdequate Pap smearsLow positive predictive valueRepeat Papanicolaou smearsSingle Pap smearVisit 6 monthsHIV-positive youthHIV-negative youthPositive cervigramHIV infectionCervical cancerProspective studyVisit 1Papanicolaou smearsUninfected adolescentsHIVPredictive valueTime of analysisAdolescent populationCervicography
1995
Prevalence of Human Papillomavirus Among STD Clinic Attenders in Jamaica
FIGUEROA J, WARD E, LUTHI T, VERMUND S, BRATHWAITE A, BURK R. Prevalence of Human Papillomavirus Among STD Clinic Attenders in Jamaica. Sexually Transmitted Diseases 1995, 22: 114-118. PMID: 7624812, DOI: 10.1097/00007435-199503000-00007.Peer-Reviewed Original ResearchConceptsHuman papillomavirus infectionHuman papillomavirusPapillomavirus infectionSTD clinicOlder womenHigh HPV prevalenceHuman papillomavirus (HPV) prevalencePrevalence of HPVSTD clinic attendersIncidence of cancerMajor etiologic agentHuman papillomavirus (HPV) genomeLow-stringency Southern blot hybridizationCross-sectional surveyHPV prevalenceEffect of ageClinic attendersCervical cancerWomen 25Risk factorsWomen 20Effective vaccineLow prevalenceWomen 15Etiologic agent
1992
Genital Human Papillomavirus Infection in Women
Kelley K, Galbraith M, Vermund S. Genital Human Papillomavirus Infection in Women. Journal Of Obstetric Gynecologic & Neonatal Nursing 1992, 21: 503-515. PMID: 1337355, DOI: 10.1111/j.1552-6909.1992.tb01771.x.Peer-Reviewed Original ResearchConceptsGenital human papillomavirus (HPV) infectionHuman papillomavirus infectionHuman papillomavirusCervical neoplasiaHPV infectionPapillomavirus infectionHIV infectionPapanicolaou testRisk factorsPrevalence of HPVCervical intraepithelial lesionsPutative precursor lesionsOutcome of therapyEffective screening toolAbnormal cervical cellsHPV typesIntraepithelial lesionsCervical cancerCondylomata acuminataPrecursor lesionsClinicians' knowledgeNeoplasiaInfectionLiterature searchYoung womenGenital papillomavirus infection and cervical dysplasia—opportunistic complications of hiv infection
Laga M, Icenogle J, Marsella R, Manoka A, Nzila N, Ryder R, Vermund S, Heyward W, Nelson A, Reeves W. Genital papillomavirus infection and cervical dysplasia—opportunistic complications of hiv infection. International Journal Of Cancer 1992, 50: 45-48. PMID: 1309459, DOI: 10.1002/ijc.2910500110.Peer-Reviewed Original ResearchConceptsCervical intra-epithelial neoplasiaHuman genital papillomavirusesHPV infectionOpportunistic complicationsSeronegative womenHIV infectionHPV typesCervical cancerPap smearHuman immunodeficiency virus (HIV) infectionHIV-seropositive womenHPV DNA testingImmunodeficiency virus infectionIntra-epithelial neoplasiaGenital papillomavirus infectionAno-genital cancersGenital HPV typesCervicovaginal lavageSeropositive womenHIV seropositivityPapillomavirus infectionCervical diseaseCervical dysplasiaHPV DNAImmunodeficiency syndrome