2010
A cluster-randomized trial of enhanced labor ward-based PMTCT services to increase nevirapine coverage in Lusaka, Zambia
Megazzini KM, Sinkala M, Vermund SH, Redden DT, Krebs DW, Acosta EP, Mwanza J, Goldenberg RL, Chintu N, Bulterys M, Stringer JS. A cluster-randomized trial of enhanced labor ward-based PMTCT services to increase nevirapine coverage in Lusaka, Zambia. AIDS 2010, 24: 447-455. PMID: 19926959, DOI: 10.1097/qad.0b013e328334b285.Peer-Reviewed Original ResearchConceptsWomen/infant pairsCluster-randomized trialNevirapine coverageInfant pairsLabour wardClinic coverageProbability of HIVProportion of HIVPrevention of motherStandard of carePMTCT programmePMTCT servicesChild transmissionHIV testingUnknown serostatusSurveillance periodIntervention periodControl clinicsRelative riskTreatment clinicsUmbilical cordHIVClinicGEE modelOdds of coverage
2009
Predictors of Rapid HIV Testing Acceptance and Successful Nevirapine Administration in Zambian Labor Wards
Megazzini KM, Chintu N, Vermund SH, Redden DT, Krebs DW, Simwenda M, Tambatamba B, Sinkala M, Stringer JS. Predictors of Rapid HIV Testing Acceptance and Successful Nevirapine Administration in Zambian Labor Wards. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2009, 52: 273-279. PMID: 19568175, DOI: 10.1097/qai.0b013e3181ab6e7c.Peer-Reviewed Original ResearchConceptsNevirapine administrationHIV testingHIV statusHIV testing acceptanceChild transmission servicesTime of admissionProvision of HIVResource-limited settingsSusceptible womenEligible womenPrimigravida womenHIV counselingCervical dilationLabour wardTesting acceptanceEligibility criteriaTesting ratesInert tabletsWomenHIVAdministrationCounselingPredictorsHoursStatus
2004
Universal nevirapine upon presentation in labor to prevent mother-to-child HIV transmission in high prevalence settings
Stringer J, Sinkala M, Goldenberg RL, Kumwenda R, Acosta EP, Aldrovandi GM, Stout JP, Vermund SH. Universal nevirapine upon presentation in labor to prevent mother-to-child HIV transmission in high prevalence settings. AIDS 2004, 18: 939-943. PMID: 15060442, PMCID: PMC2745979, DOI: 10.1097/00002030-200404090-00012.Peer-Reviewed Original ResearchConceptsChild HIV transmissionUnknown HIV serostatusHIV serostatusHIV transmissionPreliminary efficacyLabour wardHIV DNA polymerase chain reactionSingle-dose nevirapinePrevention of motherProspective cohort studyEvidence of infectionHigh-prevalence settingsWeeks of lifeNevirapine administrationNevirapine coverageChild transmissionCohort studyComparison cohortAdherence ratesPrevalence settingsPolymerase chain reactionCord bloodDNA polymerase chain reactionHIVInfant specimens