2015
Prevalence and risk factors of cervical squamous intraepithelial lesions among HIV-infected women in Dar es Salaam, Tanzania
Liu E, McCree R, Mtisi E, Fawzi WW, Aris E, Lema IA, Hertzmark E, Chalamilla G, Li N, Vermund SH, Spiegelman D. Prevalence and risk factors of cervical squamous intraepithelial lesions among HIV-infected women in Dar es Salaam, Tanzania. International Journal Of STD & AIDS 2015, 27: 219-225. PMID: 25957324, PMCID: PMC11340030, DOI: 10.1177/0956462415584466.Peer-Reviewed Original ResearchConceptsCervical squamous intraepithelial lesionsSquamous intraepithelial lesionsHIV disease stageCell countIntraepithelial lesionsDisease stageHigh-grade squamous intraepithelial lesionsAdvanced HIV disease stageCervical cancer prevention servicesLow CD4 cell countsCD4 cell countCancer prevention servicesCross-sectional studyResource-limited settingsCervical inflammationLow CD4Median CD4HIV careMedian ageCervical screeningPapanicolaou smearsRisk factorsTreatment clinicsPrevention servicesHIV
2014
Clinical Performance of Digital Cervicography and Cytology for Cervical Cancer Screening in HIV-Infected Women in Lusaka, Zambia
Bateman AC, Parham GP, Sahasrabuddhe VV, Mwanahamuntu MH, Kapambwe S, Katundu K, Nkole T, Mulundika J, Pfaendler KS, Hicks ML, Shibemba A, Vermund SH, Stringer JS, Chibwesha CJ. Clinical Performance of Digital Cervicography and Cytology for Cervical Cancer Screening in HIV-Infected Women in Lusaka, Zambia. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2014, 67: 212-215. PMID: 24977474, PMCID: PMC4162769, DOI: 10.1097/qai.0000000000000270.Peer-Reviewed Original ResearchConceptsClinical performanceDigital cervicographyCervical intraepithelial neoplasia grade 2High-grade squamous intraepithelial lesionsCervical cancer screeningSquamous intraepithelial lesionsIntraepithelial lesionsCancer screeningCervicographyGrade 2HIVCytologyWomenLesionsVisual inspectionSpecificityAssessment of High-Risk Human Papillomavirus Infections Using Clinician- and Self-Collected Cervical Sampling Methods in Rural Women from Far Western Nepal
Johnson DC, Bhatta MP, Smith JS, Kempf MC, Broker TR, Vermund SH, Chamot E, Aryal S, Lhaki P, Shrestha S. Assessment of High-Risk Human Papillomavirus Infections Using Clinician- and Self-Collected Cervical Sampling Methods in Rural Women from Far Western Nepal. PLOS ONE 2014, 9: e101255. PMID: 24978811, PMCID: PMC4076302, DOI: 10.1371/journal.pone.0101255.Peer-Reviewed Original ResearchConceptsHigh-grade squamous intraepithelial lesionsRural Nepali womenHR-HPVSquamous cell carcinomaHuman papillomavirusHigh-risk human papillomavirus infectionHigh cervical cancer ratesOverall HR-HPV prevalenceSelf-collected cervical samplesHigh-risk HPV typesGrade squamous intraepithelial lesionNepali womenClinician-collected samplesHR-HPV mRNAHR-HPV prevalenceSelf-collected testsCervical cancer ratesHuman papillomavirus infectionSelf-collected samplesSquamous intraepithelial lesionsAuxiliary nurse midwivesPre-cancer lesionsCervico-vaginal specimensSelf-collection methodType-specific distribution
2012
Implementation of cervical cancer screening using visual inspection with acetic acid in rural Mozambique: successes and challenges using HIV care and treatment programme investments in Zambézia Province
Moon TD, Silva‐Matos C, Cordoso A, Baptista AJ, Sidat M, Vermund SH. Implementation of cervical cancer screening using visual inspection with acetic acid in rural Mozambique: successes and challenges using HIV care and treatment programme investments in Zambézia Province. Journal Of The International AIDS Society 2012, 15: 17406. PMID: 22713260, PMCID: PMC3499800, DOI: 10.7448/ias.15.2.17406.Peer-Reviewed Original ResearchConceptsLoop electrosurgical excision procedureHIV careCervical cancerProvincial HospitalZambézia ProvinceCervical cancer screening servicesMaternal child health nursesAntiretroviral therapy rolloutVIA-positive womenCancer screening servicesElectrosurgical excision procedureChild health nursesSquamous intraepithelial lesionsCervical cancer screeningChronic disease screeningHealth manpower shortagesRural MozambiqueExcision procedureHIV testingIntraepithelial lesionsHIV statusClinic nursesScreening servicesCancer screeningHealth nurses
2011
Comparison of visual inspection with acetic acid and cervical cytology to detect high‐grade cervical neoplasia among HIV‐infected women in India
Sahasrabuddhe VV, Bhosale RA, Kavatkar AN, Nagwanshi CA, Joshi SN, Jenkins CA, Shepherd BE, Kelkar RS, Sahay S, Risbud AR, Vermund SH, Mehendale SM. Comparison of visual inspection with acetic acid and cervical cytology to detect high‐grade cervical neoplasia among HIV‐infected women in India. International Journal Of Cancer 2011, 130: 234-240. PMID: 21387289, PMCID: PMC3516675, DOI: 10.1002/ijc.25971.Peer-Reviewed Original ResearchMeSH KeywordsAcetatesAdultCervix UteriColposcopyCross-Sectional StudiesCytodiagnosisDNA, ViralFemaleHIVHIV InfectionsHumansIndiaMass ScreeningPapanicolaou TestPolymerase Chain ReactionPredictive Value of TestsSensitivity and SpecificityUterine Cervical DysplasiaUterine Cervical NeoplasmsVaginal SmearsConceptsCervical cytologyHigh-grade squamous intraepithelial lesionsHigh-grade cervical neoplasiaNegative predictive value estimatesScreening testHPV-positive CIN2Atypical squamous cellsSquamous intraepithelial lesionsHuman immunodeficiency virusConventional cervical cytologyPredictive value estimatesSecondary prevention methodsNonpregnant HIVRigorous endpointsAntiretroviral therapyHIV/Intraepithelial lesionsCervical neoplasiaCervical cancerImmunodeficiency virusSquamous cellsHuman papillomavirusUndetermined significanceIntraepithelial cellsCare program
2009
Anal squamous intraepithelial lesions among HIV positive and HIV negative men who have sex with men in Thailand
Li AH, Phanuphak N, Sahasrabuddhe VV, Chaithongwongwatthana S, Vermund SH, Jenkins CA, Shepherd BE, Teeratakulpisarn N, van der Lugt J, Avihingsanon A, Ruxrungtham K, Shikuma C, Phanuphak P, Ananworanich J. Anal squamous intraepithelial lesions among HIV positive and HIV negative men who have sex with men in Thailand. Sexually Transmitted Infections 2009, 85: 503. PMID: 19525263, PMCID: PMC3875384, DOI: 10.1136/sti.2009.036707.Peer-Reviewed Original ResearchConceptsAnal squamous intraepithelial lesionsHigh-grade squamous intraepithelial lesionsLow-grade squamous intraepithelial lesionsHIV-negative MSMSquamous intraepithelial lesionsHIV-positive MSMNegative MSMHIV-negative menIntraepithelial lesionsPositive MSMRisk factorsAnal condylomaNegative menActive antiretroviral therapy (HAART) useAbnormal anal cytologyAnal cancer precursorsAnal Pap smearsAnal precancerous lesionsAntiretroviral therapy useT-cell countsAtypical squamous cellsSignificant risk factorsAnal cytologyAsian HIVTherapy use
2007
Prevalence and distribution of HPV genotypes among HIV-infected women in Zambia
Sahasrabuddhe VV, Mwanahamuntu MH, Vermund SH, Huh WK, Lyon MD, Stringer JS, Parham GP. Prevalence and distribution of HPV genotypes among HIV-infected women in Zambia. British Journal Of Cancer 2007, 96: 1480-1483. PMID: 17437020, PMCID: PMC2360194, DOI: 10.1038/sj.bjc.6603737.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaHuman papillomavirusHPV 16High-grade squamous intraepithelial lesionsDistribution of HPVHigh-risk HPV typesCervical cytological abnormalitiesTertiary care centerSquamous intraepithelial lesionsNon-pregnant womenHigh-grade lesionsHigh-risk typesSensitivity of cytologyLiquid-based cytologyHPV-52HPV typesIntraepithelial lesionsProtective immunityCell carcinomaCare centerCytological abnormalitiesHPV assessmentCell countCytologyWomen
2006
Prevalence and predictors of squamous intraepithelial lesions of the cervix in HIV-infected women in Lusaka, Zambia
Parham GP, Sahasrabuddhe VV, Mwanahamuntu MH, Shepherd BE, Hicks ML, Stringer EM, Vermund SH. Prevalence and predictors of squamous intraepithelial lesions of the cervix in HIV-infected women in Lusaka, Zambia. Gynecologic Oncology 2006, 103: 1017-1022. PMID: 16875716, PMCID: PMC2748907, DOI: 10.1016/j.ygyno.2006.06.015.Peer-Reviewed Original ResearchConceptsHigh-risk HPV typesSquamous intraepithelial lesionsSquamous cell carcinomaHPV typesIntraepithelial lesionsHIV/AIDS care servicesPrevalence of SILHigh-grade squamous intraepithelial lesionsLow-grade squamous intraepithelial lesionsCervical squamous intraepithelial lesionsMultivariable logistic regression modelingNon-pregnant HIVScreening of HIVDevelopment of HPVLogistic regression modelingResource-constrained settingsResource-constrained nationsMedian CD4Abnormal cytologyAntiretroviral therapyCytological lesionsHPV typingIndependent predictorsMedian ageCervical cancer
2000
Prevalence of and Risks for Cervical Human Papillomavirus Infection and Squamous Intraepithelial Lesions in Adolescent Girls: Impact of Infection With Human Immunodeficiency Virus
Moscicki AB, Ellenberg JH, Vermund SH, Holland CA, Darragh T, Crowley-Nowick PA, Levin L, Wilson CM. Prevalence of and Risks for Cervical Human Papillomavirus Infection and Squamous Intraepithelial Lesions in Adolescent Girls: Impact of Infection With Human Immunodeficiency Virus. JAMA Pediatrics 2000, 154: 127-134. PMID: 10665598, DOI: 10.1001/archpedi.154.2.127.Peer-Reviewed Original ResearchConceptsSquamous intraepithelial lesionsHPV infectionHuman papillomavirus infectionIntraepithelial lesionsPapillomavirus infectionHIV infectionHIV statusCervical human papillomavirus infectionLow-risk HPV typesCourse of HIVNormal cytologic findingsCD4 cell countCervical HPV infectionT-cell countsT-cell immunosuppressionHuman immunodeficiency virusHigh-risk typesAdolescent girlsSexual risk behaviorsImpact of infectionCD4 immunosuppressionBaseline visitHPV typesRisky sexual behaviorViral load
1994
Risk Factors For Squamous Intraepithelial Lesions On Pap Smear In Women At Risk For Human Immunodeficiency Virus Infection
Klein R, Ho G, Vermund S, Fleming I, Burk R. Risk Factors For Squamous Intraepithelial Lesions On Pap Smear In Women At Risk For Human Immunodeficiency Virus Infection. The Journal Of Infectious Diseases 1994, 170: 1404-1409. PMID: 7995978, DOI: 10.1093/infdis/170.6.1404.Peer-Reviewed Original ResearchMeSH KeywordsAdultCarcinoma, Squamous CellCD4 Lymphocyte CountDNA, ViralFemaleHIV AntibodiesHIV InfectionsHumansImmunocompromised HostMiddle AgedMultivariate AnalysisNew YorkOdds RatioPapanicolaou TestPapillomaviridaePapillomavirus InfectionsPrevalenceRisk FactorsTumor Virus InfectionsUterine Cervical DysplasiaUterine Cervical NeoplasmsVaginal SmearsConceptsSquamous intraepithelial lesionsHuman immunodeficiency virus (HIV) infectionImmunodeficiency virus infectionRisk factorsHPV infectionHIV infectionIntraepithelial lesionsPap smearVirus infectionHigh-risk HPV typesGenital HPV infectionHIV antibody testingIndependent risk factorSevere HIVSevere immunosuppressionHPV typesAntibody testingGenital HPVUnivariate analysisMultivariate analysisInfectionGenome detectionImmunosuppressionRiskLesions
1991
Human papillomavirus infection and other risk factors for cervical neoplasia: A case‐control study
Morrison E, Ho G, Vermund S, Goldberg G, Kadish A, Kelley K, Burk R. Human papillomavirus infection and other risk factors for cervical neoplasia: A case‐control study. International Journal Of Cancer 1991, 49: 6-13. PMID: 1874571, DOI: 10.1002/ijc.2910490103.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsBase SequenceBlotting, SouthernCarcinomaCase-Control StudiesEpitheliumFemaleHumansMolecular Sequence DataMultivariate AnalysisOligonucleotidesPolymerase Chain ReactionRegression AnalysisRisk FactorsSocioeconomic FactorsTumor Virus InfectionsUterine Cervical DiseasesUterine Cervical NeoplasmsConceptsSquamous intraepithelial lesionsCervical squamous intraepithelial lesionsIndependent risk factorHPV infectionRisk factorsHigh riskCervical neoplasiaMajor independent risk factorLow educational achievementHuman papillomavirus infectionAssociation of HPVHPV types 16Major risk factorCase-control studyLogistic regression analysisCase-control designLogistic regression modelsRisk of diseaseHPV screeningIntraepithelial lesionsPapillomavirus infectionHPV typesViral loadBorderline significanceNormal womenHigh risk of human papillomavirus infection and cervical squamous intraepithelial lesions among women with symptomatic human immunodeficiency virus infection
Vermund S, Kelley K, Klein R, Feingold A, Schreiber K, Munk G, Burk R. High risk of human papillomavirus infection and cervical squamous intraepithelial lesions among women with symptomatic human immunodeficiency virus infection. American Journal Of Obstetrics And Gynecology 1991, 165: 392-400. PMID: 1651648, DOI: 10.1016/0002-9378(91)90101-v.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus (HIV) infectionSquamous intraepithelial lesionsHuman papillomavirus infectionImmunodeficiency virus infectionSymptomatic human immunodeficiency virus infectionHuman immunodeficiency virusIntraepithelial lesionsPapillomavirus infectionVirus infectionUninfected womenImmunodeficiency virusHigh riskHuman immunodeficiency virus-infected womenHuman immunodeficiency virus-related diseaseHuman immunodeficiency virus seropositiveCervical squamous intraepithelial lesionsHigh-risk womenCervical cytologic abnormalitiesVirus-related diseasesPublic health measuresAssociated immunosuppressionAsymptomatic womenCytologic abnormalitiesHuman papillomavirusHealth measures
1990
Cervical cytologic abnormalities and papillomavirus in women infected with human immunodeficiency virus.
Feingold AR, Vermund SH, Burk RD, Kelley KF, Schrager LK, Schreiber K, Munk G, Friedland GH, Klein RS. Cervical cytologic abnormalities and papillomavirus in women infected with human immunodeficiency virus. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1990, 3: 896-903. PMID: 2166784.Peer-Reviewed Original ResearchConceptsSquamous intraepithelial lesionsHIV-positive womenCervical cytologic abnormalitiesCytologic abnormalitiesCervical cytologyAsymptomatic HIV-positive womenHuman immunodeficiency virus (HIV) infectionHIV-negative womenHuman papillomavirus infectionImmunodeficiency virus infectionSymptomatic HIV infectionIntravenous drug useHuman immunodeficiency virusIntravenous drug usersFemale genital tractWestern blot confirmationCervicovaginal lavageHPV determinationSeronegative womenHPV infectionPapillomavirus infectionCytological lesionsHIV infectionIntraepithelial lesionsImmunodeficiency virus