2022
Antiretroviral therapy resistance mutations among HIV infected people in Kazakhstan
Mukhatayeva A, Mustafa A, Dzissyuk N, Issanov A, Mukhatayev Z, Bayserkin B, Vermund SH, Ali S. Antiretroviral therapy resistance mutations among HIV infected people in Kazakhstan. Scientific Reports 2022, 12: 17195. PMID: 36229577, PMCID: PMC9562405, DOI: 10.1038/s41598-022-22163-7.Peer-Reviewed Original ResearchCOVID-19 Clinical Presentation Among HIV-Infected Persons in China: A Systematic Review
Huang D, Zunong J, Li M, Li D, Gong J, Vermund SH, Hu Y. COVID-19 Clinical Presentation Among HIV-Infected Persons in China: A Systematic Review. Current HIV/AIDS Reports 2022, 19: 167-176. PMID: 35394249, PMCID: PMC8990500, DOI: 10.1007/s11904-022-00606-0.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyCOVID-19 clinical severityCOVID-19 clinical presentationCOVID-19Undetectable viral loadAsymptomatic COVID-19Severe COVID-19Last clinical visitCase series/reportsCase fatality rateCOVID-19 prognosisLate antiretroviral therapyIL-6 resultsSARS-CoV-2COVID-19 diagnosisMedian CD4Gastrointestinal symptomsHIV infectionMedian ageRespiratory distressClinical featuresClinical presentationClinical visitsViral loadClinical details
2018
Exploration of Implementation Patterns and Content from a Text-Based Outreach Intervention Clinical Trial for Newly Diagnosed, HIV-Positive MSM in Beijing, China
Knudson A, Shaw S, Yin L, Xiao D, Qian HZ, Sullivan S, Liu H, Ruan Y, Shao Y, Vermund SH, Amico KR. Exploration of Implementation Patterns and Content from a Text-Based Outreach Intervention Clinical Trial for Newly Diagnosed, HIV-Positive MSM in Beijing, China. AIDS And Behavior 2018, 23: 1158-1165. PMID: 30288683, PMCID: PMC6566097, DOI: 10.1007/s10461-018-2287-y.Peer-Reviewed Original Research
2013
Can Combination Prevention Strategies Reduce HIV Transmission in Generalized Epidemic Settings in Africa? The HPTN 071 (PopART) Study Plan in South Africa and Zambia
Vermund SH, Fidler SJ, Ayles H, Beyers N, Hayes RJ. Can Combination Prevention Strategies Reduce HIV Transmission in Generalized Epidemic Settings in Africa? The HPTN 071 (PopART) Study Plan in South Africa and Zambia. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2013, 63: s221-s227. PMID: 23764639, PMCID: PMC3739051, DOI: 10.1097/qai.0b013e318299c3f4.Peer-Reviewed Original ResearchConceptsHIV Prevention Trials NetworkHPTN 071 (PopART) studyHPTN 071HIV incidenceHIV transmissionHome-based HIV testingVoluntary medical male circumcisionGeneralized epidemic settingsLinkage of HIVUniversal antiretroviral therapyChild HIV transmissionPrevention of motherHIV viral loadCommunity health workersMedical male circumcisionCommunity-randomized trialIntervention strategiesCombination prevention strategiesAntiretroviral therapyHIV acquisitionSeropositive personsTuberculosis servicesHIV testingViral loadTuberculosis transmission
2012
Oral Lesions: Poor Markers of Virologic Failure in HIV‐Infected Patients on Antiretroviral Therapy
Tami-Maury I, Willig J, Jolly P, Vermund S, Aban I, Hill J, Wilson C. Oral Lesions: Poor Markers of Virologic Failure in HIV‐Infected Patients on Antiretroviral Therapy. International Scholarly Research Notices 2012, 2013: 1-7. DOI: 10.5402/2013/269728.Peer-Reviewed Original ResearchPositive predictive valueVirologic failureAntiretroviral therapyPredictive valueViral loadHigh baseline viral loadMonths of ARTModerate positive predictive valueBaseline viral loadStrong positive predictive valueNegative predictive valueVirologic statusBaseline factorsCopies/Poor markerPatientsMental disordersOL groupTherapyMonthsHIVArt therapyPoor predictorMarkersFailurePrevention, Detection, and Treatment of Coinfections: A Priority in Human Immunodeficiency Virus–Infected Persons to Reduce Viral Load and Consequent Disease Progression and Transmission : Comment on “Effect of Early Syphilis Infection on Plasma Viral Load and CD4 Cell Count in Human Immunodeficiency Virus–Infected Men”
Vermund SH. Prevention, Detection, and Treatment of Coinfections: A Priority in Human Immunodeficiency Virus–Infected Persons to Reduce Viral Load and Consequent Disease Progression and Transmission : Comment on “Effect of Early Syphilis Infection on Plasma Viral Load and CD4 Cell Count in Human Immunodeficiency Virus–Infected Men”. JAMA Internal Medicine 2012, 172: 1243-1244. PMID: 22824925, DOI: 10.1001/archinternmed.2012.3770.Peer-Reviewed Original Research
2011
Contemporary profile of oral manifestations of HIV/AIDS and associated risk factors in a southeastern US clinic
Tamí‐Maury I, Willig J, Vermund S, Jolly P, Aban I, Hill J, Wilson CM. Contemporary profile of oral manifestations of HIV/AIDS and associated risk factors in a southeastern US clinic. Journal Of Public Health Dentistry 2011, 71: 257-264. PMID: 22320283, DOI: 10.1111/j.1752-7325.2011.00256.x.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAdultAIDS-Related Opportunistic InfectionsAntiretroviral Therapy, Highly ActiveBlack or African AmericanCandidiasis, OralCD4 Lymphocyte CountCohort StudiesFemaleFollow-Up StudiesHeterosexualityHIV InfectionsHIV-1Homosexuality, MaleHumansMaleMouth DiseasesOropharynxPharyngeal DiseasesPrevalenceRetrospective StudiesRisk FactorsSex FactorsSoutheastern United StatesViral LoadYoung AdultConceptsOral manifestationsOropharyngeal candidiasisRisk factorsUS clinicsHIV-1 RNA viral loadLow baseline CD4 countBaseline CD4 valueMean baseline CD4Active antiretroviral therapyBaseline CD4 countRNA viral loadHIV-positive individualsHIV/AIDSLogistic regression modelsBaseline CD4Antiretroviral therapyCD4 countLaboratory characteristicsRetrospective reviewCD4 valuesViral loadHIV prevalenceMean ageT cellsHAART
2010
Effect of treating co-infections on HIV-1 viral load: a systematic review
Modjarrad K, Vermund SH. Effect of treating co-infections on HIV-1 viral load: a systematic review. The Lancet Infectious Diseases 2010, 10: 455-463. PMID: 20610327, PMCID: PMC3071714, DOI: 10.1016/s1473-3099(10)70093-1.Peer-Reviewed Original ResearchConceptsViral load differencesViral loadPlasma HIV-1 RNA concentrationSystematic reviewMean plasma viral loadPlasma HIV RNA concentrationHIV-1 RNA concentrationsHIV-1 viral loadHIV RNA concentrationPlasma viral loadHIV transmission riskViral load reductionNon-pathogenic infectionsCo-infecting pathogensSyphilis treatmentHIV progressionTuberculosis treatmentEligible studiesPopulation-level benefitsTransmission riskLow-income countriesHIVTreatmentInfectionReview
2009
Predictors of Suboptimal Virologic Response to Highly Active Antiretroviral Therapy Among Human Immunodeficiency Virus–Infected Adolescents: Analyses of the Reaching for Excellence in Adolescent Care and Health (REACH) Project
Ding H, Wilson CM, Modjarrad K, McGwin G, Tang J, Vermund SH. Predictors of Suboptimal Virologic Response to Highly Active Antiretroviral Therapy Among Human Immunodeficiency Virus–Infected Adolescents: Analyses of the Reaching for Excellence in Adolescent Care and Health (REACH) Project. JAMA Pediatrics 2009, 163: 1100-1105. PMID: 19996046, PMCID: PMC3739292, DOI: 10.1001/archpediatrics.2009.204.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAntiretroviral Therapy, Highly ActiveCD4 Lymphocyte CountChi-Square DistributionFemaleHIV InfectionsHumansInterviews as TopicLogistic ModelsMalePatient CompliancePredictive Value of TestsPrevalenceProspective StudiesStatistics, NonparametricTreatment OutcomeUnited StatesViral LoadYoung AdultConceptsHuman immunodeficiency virus-infected adolescentsSuboptimal virologic responsePoor virologic responseVirologic responseActive antiretroviral therapyAntiretroviral therapyVirologic suppressionMultivariable logistic regression modelDual antiretroviral therapyInitiation of HAARTSuboptimal antiretroviral therapyAge-specific interventionsAcademic medical centerLogistic regression modelsCohort studyLymphocyte countViral loadEcho findingsAdequate adherenceTherapeutic failureBiopsychosocial predictorsHAARTMedical CenterAdolescent careConsecutive visits
2008
Impact of small reductions in plasma HIV RNA levels on the risk of heterosexual transmission and disease progression
Modjarrad K, Chamot E, Vermund SH. Impact of small reductions in plasma HIV RNA levels on the risk of heterosexual transmission and disease progression. AIDS 2008, 22: 2179-2185. PMID: 18832881, PMCID: PMC2661869, DOI: 10.1097/qad.0b013e328312c756.Peer-Reviewed Original ResearchConceptsRisk of progressionHeterosexual transmissionDisease progressionHIV RNALog10 incrementAntiretroviral therapyPlasma HIV RNA levelsGreater riskTreatment of coinfectionHIV RNA levelsHIV viral loadViral load changesHIV-1 RNARelative risk estimatesHIV loadAdjunctive careViral loadPlasma levelsHeterosexual contactWorld's HIVAnnual riskHIVAdult populationViral transmissionRisk estimates
2007
Influence of body mass index on pregnancy outcomes among HIV‐infected and HIV‐uninfected Zambian women
Banda Y, Chapman V, Goldenberg RL, H. B, Vermund SH, Stringer JS. Influence of body mass index on pregnancy outcomes among HIV‐infected and HIV‐uninfected Zambian women. Tropical Medicine And International Health 2007, 12: 856-861. PMID: 17596253, PMCID: PMC2570322, DOI: 10.1111/j.1365-3156.2007.01857.x.Peer-Reviewed Original ResearchConceptsBody mass indexPregnancy outcomesBirth weightInfant weightMass indexZambian womenBMI unitsLower body mass indexChild transmission ratePerinatal HIV transmissionPrevention of motherHIV viral loadInfant birth weightMean birth weightTransmission of HIVNevirapine administrationPrior stillbirthBMI quartilesCD4 countChild transmissionViral loadHIV transmissionMaternal parityUnivariate analysisClinical trials
2005
Does Severity of HIV Disease in HIV-Infected Mothers Affect Mortality and Morbidity among Their Uninfected Infants?
Kuhn L, Kasonde P, Sinkala M, Kankasa C, Semrau K, Scott N, Tsai WY, Vermund SH, Aldrovandi GM, Thea DM. Does Severity of HIV Disease in HIV-Infected Mothers Affect Mortality and Morbidity among Their Uninfected Infants? Clinical Infectious Diseases 2005, 41: 1654-1661. PMID: 16267740, PMCID: PMC1351118, DOI: 10.1086/498029.Peer-Reviewed Original ResearchConceptsMonths of ageUninfected infantsHIV diseaseAdvanced diseasePerinatal human immunodeficiency virus (HIV) transmissionAdvanced maternal HIV diseaseHuman immunodeficiency virus (HIV) transmissionHIV-uninfected infantsLower child weightMaternal HIV diseaseMaternal viral loadT-cell countsCells/microLLow birth weightInfants of mothersHealth of infantsMonths of lifeMaternal diseaseHIV infectionHospital admissionImmune dysfunctionInfant weightMaternal deathsViral loadBirth weightTreatment of Intestinal Helminths Does Not Reduce Plasma Concentrations of HIV-1 RNA in Coinfected Zambian Adults
Modjarrad K, Zulu I, Redden DT, Njobvu L, Lane HC, Bentwich Z, Vermund SH. Treatment of Intestinal Helminths Does Not Reduce Plasma Concentrations of HIV-1 RNA in Coinfected Zambian Adults. The Journal Of Infectious Diseases 2005, 192: 1277-1283. PMID: 16136473, PMCID: PMC2730764, DOI: 10.1086/444543.Peer-Reviewed Original ResearchConceptsHIV-1 RNAViral loadPlasma concentrationsAntihelminthic treatmentCopies/Helminth infectionsIntestinal helminthsHigh pretreatment viral loadMedian baseline viral loadPretreatment viral loadBaseline viral loadDysfunctional immune responseIntestinal helminth infectionsHuman immunodeficiency virusMean viral loadCopies/mLHigher helminth burdensPosttreatment visitAsymptomatic adultsImmunodeficiency virusProspective studyZambian adultsUninfected groupHIV-1Immune response
2004
Prevention of mother-to-child transmission of HIV in Africa.
Vermund SH. Prevention of mother-to-child transmission of HIV in Africa. Topics In Antiviral Medicine 2004, 12: 130-4. PMID: 15647608.Peer-Reviewed Original ResearchConceptsChild transmissionHIV infectionInternational AIDS Society-USA courseMaternal plasma viral loadExclusive formula feedingNevirapine resistance mutationsSingle-dose nevirapinePrevention of motherPlasma viral loadPerinatal transmission ratePerinatal transmissionAntiretroviral therapyExclusive breastfeedingFormula feedingViral loadMaternal mortalityRisk factorsMortality rateHIVAfrican childrenMixed feedingGreater riskResistance mutationsEarly weaningBreastfeeding
2003
Timing of the maternal drug dose and risk of perinatal HIV transmission in the setting of intrapartum and neonatal single-dose nevirapine
Stringer J, Sinkala M, Chapman V, Acosta EP, Aldrovandi GM, Mudenda V, Stout JP, Goldenberg RL, Kumwenda R, Vermund SH. Timing of the maternal drug dose and risk of perinatal HIV transmission in the setting of intrapartum and neonatal single-dose nevirapine. AIDS 2003, 17: 1659-1665. PMID: 12853748, PMCID: PMC2745973, DOI: 10.1097/00002030-200307250-00010.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBreast FeedingDrug Administration ScheduleFemaleHIV InfectionsHIV SeropositivityHumansInfant, NewbornInfectious Disease Transmission, VerticalLabor, ObstetricNevirapineObstetric Labor ComplicationsPregnancyPregnancy Complications, InfectiousProspective StudiesReverse Transcriptase InhibitorsRisk FactorsTime FactorsConceptsPerinatal HIV transmissionHIV transmissionInfant HIV infection statusNeonatal single-dose nevirapineMaternal drug doseSingle-dose nevirapineHIV infection statusProspective cohort studyPerinatal transmission rateOnset of laborMain outcome measuresMean drug concentrationWeeks of lifeRisk of transmissionNVP levelsNVP prophylaxisNVP syrupObstetrical clinicPerinatal transmissionCohort studyOral doseViral loadPregnant womenPolymerase chain reactionRisk factors
2002
Host genetic profiles predict virological and immunological control of HIV-1 infection in adolescents
Tang J, Wilson CM, Meleth S, Myracle A, Lobashevsky E, Mulligan MJ, Douglas SD, Korber B, Vermund SH, Kaslow RA. Host genetic profiles predict virological and immunological control of HIV-1 infection in adolescents. AIDS 2002, 16: 2275-2284. PMID: 12441799, DOI: 10.1097/00002030-200211220-00007.Peer-Reviewed Original ResearchConceptsViral loadHLA class IHost genetic profileHIV-1-infected adolescentsHIV-1-seropositive participantsCD4 T-cell countClass IHIV-seronegative individualsT-cell countsCD4 T lymphocytesHIV-1 infectionHIV-1 pathogenesisGenetic profileClinical patient groupsAntiretroviral therapyQuarterly followMultivariable analysisHealth cohortPatient groupImmunological outcomesImmunological controlNegative HLAT lymphocytesProtective effectAdolescent care
2001
Virologic and Immunologic Determinants of Heterosexual Transmission of Human Immunodeficiency Virus Type 1 in Africa
Fideli L, Allen S, Musonda R, Trask S, Hahn B, Weiss H, Mulenga J, Kasolo F, Vermund S, Aldrovandi G. Virologic and Immunologic Determinants of Heterosexual Transmission of Human Immunodeficiency Virus Type 1 in Africa. AIDS Research And Human Retroviruses 2001, 17: 901-910. PMID: 11461676, PMCID: PMC2748905, DOI: 10.1089/088922201750290023.Peer-Reviewed Original ResearchConceptsCopies/Heterosexual transmissionRisk ratioMultivariate Cox regression analysisHuman immunodeficiency virus type 1Immunodeficiency virus type 1Plasma viral loadCox regression analysisCorresponding risk ratioHIV-1 RNAVirus type 1Female transmissionCase-control designGender-specific differencesPlasma VLImmunologic correlatesViral loadProspective studySerology resultsWorld's HIVVirus isolationType 1Immunologic determinantsReference groupNontransmitters
2000
Prevalence of and Risks for Cervical Human Papillomavirus Infection and Squamous Intraepithelial Lesions in Adolescent Girls: Impact of Infection With Human Immunodeficiency Virus
Moscicki AB, Ellenberg JH, Vermund SH, Holland CA, Darragh T, Crowley-Nowick PA, Levin L, Wilson CM. Prevalence of and Risks for Cervical Human Papillomavirus Infection and Squamous Intraepithelial Lesions in Adolescent Girls: Impact of Infection With Human Immunodeficiency Virus. JAMA Pediatrics 2000, 154: 127-134. PMID: 10665598, DOI: 10.1001/archpedi.154.2.127.Peer-Reviewed Original ResearchConceptsSquamous intraepithelial lesionsHPV infectionHuman papillomavirus infectionIntraepithelial lesionsPapillomavirus infectionHIV infectionHIV statusCervical human papillomavirus infectionLow-risk HPV typesCourse of HIVNormal cytologic findingsCD4 cell countCervical HPV infectionT-cell countsT-cell immunosuppressionHuman immunodeficiency virusHigh-risk typesAdolescent girlsSexual risk behaviorsImpact of infectionCD4 immunosuppressionBaseline visitHPV typesRisky sexual behaviorViral load
1998
Serum Retinol and HIV-1 RNA Viral Load in Rapid and Slow Progressors
Camp W, Allen S, Alvarez J, Jolly P, Weiss H, Phillips J, Karita E, Serufilira A, Vermund S. Serum Retinol and HIV-1 RNA Viral Load in Rapid and Slow Progressors. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1998, 18: 401-406. PMID: 9704954, DOI: 10.1097/00042560-199808010-00022.Peer-Reviewed Original ResearchConceptsSerum retinol levelsHIV-1 RNA viral loadLow viral loadLow serum retinol levelsRNA viral loadSlow progressorsRetinol levelsViral loadHIV serologySerum retinolDisease progressionFirst HIV-positive testHigher serum retinol levelsAsymptomatic HIV infectionHigh HIV loadLow serum retinolSerum retinol valuesHIV disease progressionHIV-positive testHigh viral loadThirty HIVHIV loadHIV infectionRapid progressorsSerum vitaminSerum Retinol and HIV-1 RNA Viral Load in Rapid and Slow Progressors
Camp W, Allen S, Alvarez J, Jolly P, Weiss H, Phillips J, Karita E, Serufilira A, Vermund S. Serum Retinol and HIV-1 RNA Viral Load in Rapid and Slow Progressors. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1998, 18: 21-26. PMID: 9593454, DOI: 10.1097/00042560-199805010-00004.Peer-Reviewed Original ResearchConceptsSerum retinol levelsLow viral loadHIV-1 RNA viral loadLow serum retinol levelsRNA viral loadSlow progressorsRetinol levelsViral loadHIV serologySerum retinolDisease progressionFirst HIV-positive testHigher serum retinol levelsAsymptomatic HIV infectionHigh HIV loadLow serum retinolSerum retinol valuesHIV disease progressionHIV-positive testHigh viral loadThirty HIVHIV loadHIV infectionRapid progressorsSerum vitamin