2009
Early Neurologic Abnormalities Associated with Human T-Cell Lymphotropic Virus Type 1 Infection in a Cohort of Peruvian Children
Kendall EA, González E, Espinoza I, Tipismana M, Verdonck K, Clark D, Vermund SH, Gotuzzo E. Early Neurologic Abnormalities Associated with Human T-Cell Lymphotropic Virus Type 1 Infection in a Cohort of Peruvian Children. The Journal Of Pediatrics 2009, 155: 700-706. PMID: 19628219, PMCID: PMC2764792, DOI: 10.1016/j.jpeds.2009.05.027.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge DistributionAge of OnsetCase-Control StudiesChildChild, PreschoolCohort StudiesConfidence IntervalsFemaleHTLV-I InfectionsHuman T-lymphotropic virus 1HumansInfectious Disease Transmission, VerticalMaleNeurologic ExaminationOdds RatioParaparesisParaparesis, Tropical SpasticPeruPrevalenceProbabilityRisk AssessmentSeverity of Illness IndexSex DistributionSpinal Cord DiseasesTime FactorsUrination DisordersConceptsParesthesia/dysesthesiaHTLV-1 infectionNeurologic abnormalitiesInfective dermatitisHTLV-1Lumbar painHuman T-cell lymphotropic virus type 1 infectionMyelopathy/tropical spastic paraparesisHuman T-cell lymphotropic virus type 1Virus type 1 infectionPeruvian childrenAbnormal neurologic findingsEarly Neurologic AbnormalitiesLower extremity hyperreflexiaStandardized neurologic examinationType 1 infectionTropical spastic paraparesisWeakness/fatigueHTLV-1 statusVirus type 1Uninfected childrenNeurologic findingsNeurologic symptomsUrinary disturbanceNeurologic examination
2005
Prevalence and predictors of intestinal helminth infections among human immunodeficiency virus type 1-infected adults in an urban African setting.
Modjarrad K, Zulu I, Redden DT, Njobvu L, Freedman DO, Vermund SH. Prevalence and predictors of intestinal helminth infections among human immunodeficiency virus type 1-infected adults in an urban African setting. American Journal Of Tropical Medicine And Hygiene 2005, 73: 777-82. PMID: 16222025, PMCID: PMC2749260, DOI: 10.4269/ajtmh.2005.73.777.Peer-Reviewed Original ResearchConceptsHIV-1-infected adultsIntestinal helminth infectionsHelminth infectionsUrban African settingIntestinal helminthsHuman immunodeficiency virus type 1Immunodeficiency virus type 1Detrimental immunologic effectsRoutine HIV careAfrican settingHuman immunodeficiency virusLight-intensity infectionsHIV infection ratesVirus type 1HIV careImmunologic effectsConcomitant infectionImmunodeficiency virusPrior historyHelminth diagnosisAscaris lumbricoidesHelminth statusParasitologic dataInfection rateInfection
2003
CC Chemokine Receptor 5 Genotype and Susceptibility to Transmission of Human Immunodeficiency Virus Type 1 in Women
Philpott S, Weiser B, Tarwater P, Vermund SH, Kleeberger CA, Gange SJ, Anastos K, Cohen M, Greenblatt RM, Kovacs A, Minkoff H, Young MA, Miotti P, Dupuis M, Chen CH, Burger H. CC Chemokine Receptor 5 Genotype and Susceptibility to Transmission of Human Immunodeficiency Virus Type 1 in Women. The Journal Of Infectious Diseases 2003, 187: 569-575. PMID: 12599073, PMCID: PMC3319124, DOI: 10.1086/367995.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus type 1Immunodeficiency virus type 1Virus type 1HIV-1-seronegative womenHIV-1-seropositive womenDelta 32Women's Interagency HIV StudyType 1CC chemokine receptor 5HIV-1 transmissionHIV-1 infectionChemokine receptor 5Differential genetic susceptibilityHeterosexual spreadHIV StudyHIV-1Receptor 5Male cohortGenetic susceptibilityPartial protectionWomenBehavioral factorsInfectionHeterozygous genotypeMost studies
2002
Correlates of Nontransmission in US Women at High Risk of Human Immunodeficiency Virus Type 1 Infection through Sexual Exposure
Skurnick JH, Palumbo P, DeVico A, Shacklett BL, Valentine FT, Merges M, Kamin-Lewis R, Mestecky J, Denny T, Lewis GK, Lloyd J, Praschunus R, Baker A, Nixon DF, Stranford S, Gallo R, Vermund SH, Louria DB. Correlates of Nontransmission in US Women at High Risk of Human Immunodeficiency Virus Type 1 Infection through Sexual Exposure. The Journal Of Infectious Diseases 2002, 185: 428-438. PMID: 11865394, PMCID: PMC2743095, DOI: 10.1086/338830.Peer-Reviewed Original ResearchConceptsSexual exposureSuppressive activityHuman immunodeficiency virus type 1 (HIV-1) infectionHigher CD8 cell countsHIV-1-suppressive activitySingle-cell cytokine productionHuman immunodeficiency virus type 1Macrophage inflammatory protein-1 betaVirus type 1 infectionHIV-positive male partnersInflammatory protein-1 betaMale partnersImmunodeficiency virus type 1CD4 cell responseCD8 cell countsHIV-positive donorsHIV-positive partnerHIV-negative partnersType 1 infectionInterferon-gamma secretionHIV-suppressive activityVirus type 1Apparent protective roleHIV antigenLocal antibodies
2001
Virologic and Immunologic Determinants of Heterosexual Transmission of Human Immunodeficiency Virus Type 1 in Africa
Fideli L, Allen S, Musonda R, Trask S, Hahn B, Weiss H, Mulenga J, Kasolo F, Vermund S, Aldrovandi G. Virologic and Immunologic Determinants of Heterosexual Transmission of Human Immunodeficiency Virus Type 1 in Africa. AIDS Research And Human Retroviruses 2001, 17: 901-910. PMID: 11461676, PMCID: PMC2748905, DOI: 10.1089/088922201750290023.Peer-Reviewed Original ResearchConceptsCopies/Heterosexual transmissionRisk ratioMultivariate Cox regression analysisHuman immunodeficiency virus type 1Immunodeficiency virus type 1Plasma viral loadCox regression analysisCorresponding risk ratioHIV-1 RNAVirus type 1Female transmissionCase-control designGender-specific differencesPlasma VLImmunologic correlatesViral loadProspective studySerology resultsWorld's HIVVirus isolationType 1Immunologic determinantsReference groupNontransmitters
1998
Behavioral and Demographic Risk Factors for Transmission of Human Immunodeficiency Virus Type 1 in Heterosexual Couples: Report from the Heterosexual HIV Transmission Study
Skurnick J, Kennedy C, Perez G, Abrams J, Vermund S, Denny T, Wright T, Quinones M, Louria D. Behavioral and Demographic Risk Factors for Transmission of Human Immunodeficiency Virus Type 1 in Heterosexual Couples: Report from the Heterosexual HIV Transmission Study. Clinical Infectious Diseases 1998, 26: 855-864. PMID: 9564464, DOI: 10.1086/513929.Peer-Reviewed Original ResearchConceptsHIV-concordant couplesRisk factorsAnal sexHuman immunodeficiency virus type 1 (HIV-1) infectionHeterosexual HIV transmission studyHuman immunodeficiency virus type 1Virus type 1 infectionImmunodeficiency virus type 1HIV transmission studyHIV-discordant couplesStage of diseaseType 1 infectionBehavioral risk factorsUnprotected vaginal sexDemographic risk factorsMultivariate logistic modelVirus type 1Sexual risk behaviorsPartner infectionUninfected womenAntiviral therapyHIV transmissionDiscordant couplesPap smearGrade 2Immunological and Virological Analyses of Persons Infected by Human Immunodeficiency Virus Type 1 while Participating in Trials of Recombinant gp120 Subunit Vaccines
Connor RI, Korber B, Graham BS, Hahn BH, Ho DD, Walker BD, Neumann AU, Vermund SH, Mestecky J, Jackson S, Fenamore E, Cao Y, Gao F, Kalams S, Kunstman KJ, McDonald D, McWilliams N, Trkola A, Moore JP, Wolinsky SM. Immunological and Virological Analyses of Persons Infected by Human Immunodeficiency Virus Type 1 while Participating in Trials of Recombinant gp120 Subunit Vaccines. Journal Of Virology 1998, 72: 1552-1576. PMID: 9445059, PMCID: PMC124637, DOI: 10.1128/jvi.72.2.1552-1576.1998.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus type 1Immunodeficiency virus type 1Virus type 1MN rgp120Antibody responseHIV-1Recombinant gp120 subunit vaccinePhase I/II clinical trialsCytotoxic T lymphocyte responsesType 1Immunoglobulin G antibody responseGp120 subunit vaccineSyncytium-inducing (SI) phenotypeT lymphocyte responsesG antibody responseClade B virusesInducing (NSI) phenotypeInfected vaccineesNSI strainsPlacebo recipientsVaccine recipientsViral burdenPlacebo vaccineAntibody titersMultiple immunizations
1994
Incidence Of Clinical Aids Conditions In A Cohort Of Homosexual Men With CD4+ Cell Counts <100/mm3
Bacellar H, Muñoz A, Hoover D, Phair J, Besley D, Kingsley L, Vermund S, Study F. Incidence Of Clinical Aids Conditions In A Cohort Of Homosexual Men With CD4+ Cell Counts <100/mm3. The Journal Of Infectious Diseases 1994, 170: 1284-1287. PMID: 7963728, DOI: 10.1093/infdis/170.5.1284.Peer-Reviewed Original ResearchConceptsIncidence rateHomosexual menCD4 cells/mm3P. carinii pneumonia prophylaxisHuman immunodeficiency virus type 1Multicenter AIDS Cohort StudyImmunodeficiency virus type 1Cells/mm3Use of antiretroviralsPneumocystis carinii pneumoniaAIDS Cohort StudyHealth care providersMycobacterium avium complexVirus type 1Cytomegalovirus diseasePneumonia prophylaxisCytomegalovirus retinitisAIDS illnessCohort studyOpportunistic infectionsAIDS conditionsCarinii pneumoniaClinical trialsKaposi's sarcomaCare providers
1993
Trends in the Incidence of Outcomes Defining Acquired Immunodeficiency Syndrome (AIDS) in the Multicenter AIDS Cohort Study: 1985–1991
Muñoz A, Schrager L, Bacellar H, Speizer I, Vermund S, Detels R, Saah A, Kingsley L, Seminara D, Phair J. Trends in the Incidence of Outcomes Defining Acquired Immunodeficiency Syndrome (AIDS) in the Multicenter AIDS Cohort Study: 1985–1991. American Journal Of Epidemiology 1993, 137: 423-438. PMID: 8096356, DOI: 10.1093/oxfordjournals.aje.a116691.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAIDS-Related Opportunistic InfectionsCD4-Positive T-LymphocytesCohort StudiesCytomegalovirus InfectionsHerpes SimplexHIV SeropositivityHIV-1HumansIncidenceLeukocyte CountLymphomaMaleNervous System DiseasesPneumonia, PneumocystisProspective StudiesRegression AnalysisRisk FactorsSarcoma, KaposiUnited StatesConceptsAcquired Immunodeficiency SyndromeP. carinii pneumoniaCarinii pneumoniaProgressive immunosuppressionKaposi's sarcomaImmunodeficiency syndromeOpportunistic infectionsHerpes simplex virus infectionHuman immunodeficiency virus type 1Multicenter AIDS Cohort StudyImmunodeficiency virus type 1Use of chemoprophylaxisUse of prophylaxisIncidence of outcomesPneumocystis carinii pneumoniaSimplex virus infectionAIDS Cohort StudyVirus type 1Antiretroviral therapyCohort studyClinical outcomesInitial diagnosisSecondary diagnosisLower incidenceNeurologic disease
1991
Estimating the 1978–1990 and Future Spread of Human Immunodeficiency Virus Type 1 in Subgroups of Homosexual Men
Hoover D, Munoz A, Carey V, Chmiel J, Taylor J, Margolick J, Kingsley L, Vermund S. Estimating the 1978–1990 and Future Spread of Human Immunodeficiency Virus Type 1 in Subgroups of Homosexual Men. American Journal Of Epidemiology 1991, 134: 1190-1205. PMID: 1746529, DOI: 10.1093/oxfordjournals.aje.a116022.Peer-Reviewed Original ResearchConceptsSeroconversion ratesHomosexual menHuman immunodeficiency virus type 1 (HIV-1) infectionHuman immunodeficiency virus type 1Virus type 1 infectionImmunodeficiency virus type 1Kaplan-Meier methodHIV-1 infectionType 1 infectionAge 55 yearsHIV-1 epidemicVirus type 1AIDS diagnosisSeroconversionAnnual hazardHematologic variablesAge 55Type 1Survival methodsBisexual menHomosexual populationCohortMenAgeInfection