2021
Human Immunodeficiency Virus Infection and Incident Heart Failure: A Meta-Analysis of Prospective Studies
Chen Y, Gao Y, Zhou Y, Li X, Wang H, Polonsky TS, Vermund SH, Qian HZ, Qian F. Human Immunodeficiency Virus Infection and Incident Heart Failure: A Meta-Analysis of Prospective Studies. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2021, 87: 741-749. PMID: 33492019, PMCID: PMC10768809, DOI: 10.1097/qai.0000000000002629.Peer-Reviewed Original ResearchMeSH KeywordsAdultCD4 Lymphocyte CountDatabases, FactualFemaleHeart FailureHIV InfectionsHumansIncidenceProspective StudiesRiskConceptsIncident heart failureLow CD4 countHeart failureHIV infectionRandom-effects modelCD4 countSubgroup analysisRisk of HFHuman immunodeficiency virus (HIV) infectionLaird random-effects modelYoung adultsAvailable prospective evidenceImmunodeficiency virus infectionPooled relative riskFull-text assessmentWeb of ScienceFixed-effects modelProspective studyIncident casesProspective evidenceRelative riskVirus infectionFunnel plotMeta-AnalysisSimilar association
2017
Control of HIV epidemic: improve access to testing and ART
Vermund SH. Control of HIV epidemic: improve access to testing and ART. The Lancet HIV 2017, 4: e533-e534. PMID: 28867268, PMCID: PMC10950070, DOI: 10.1016/s2352-3018(17)30166-2.Peer-Reviewed Original ResearchMobility and Clinic Switching Among Postpartum Women Considered Lost to HIV Care in South Africa
Clouse K, Vermund SH, Maskew M, Lurie MN, MacLeod W, Malete G, Carmona S, Sherman G, Fox MP. Mobility and Clinic Switching Among Postpartum Women Considered Lost to HIV Care in South Africa. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2017, 74: 383-389. PMID: 28225717, PMCID: PMC5324708, DOI: 10.1097/qai.0000000000001284.Peer-Reviewed Original ResearchConceptsHIV careNational Health Laboratory Service databaseLow CD4 cell countsNational Antiretroviral Therapy ProgramCD4 cell countObservational cohort studyAntiretroviral therapy programsAntiretroviral therapyCohort studyPostpartum womenPublic clinicsService databaseCell countTherapy programCareWomenLTFUClinicOne-thirdDaysPatientsPregnancyTherapyImpact of Depression and Anxiety on Initiation of Antiretroviral Therapy Among Men Who Have Sex with Men with Newly Diagnosed HIV Infections in China
Tao J, Vermund SH, Lu H, Ruan Y, Shepherd BE, Kipp AM, Amico KR, Zhang X, Shao Y, Qian HZ. Impact of Depression and Anxiety on Initiation of Antiretroviral Therapy Among Men Who Have Sex with Men with Newly Diagnosed HIV Infections in China. AIDS Patient Care And STDs 2017, 31: 96-104. PMID: 28170305, PMCID: PMC5312604, DOI: 10.1089/apc.2016.0214.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyART initiationHIV diagnosisHIV infectionDepression scoresEarly ART initiationNational ART databaseNew HIV diagnosesImpact of depressionEffect of depressionProspective cohortBorderline depressionCox regressionHADS scoresBaseline prevalenceEligible participantsHospital AnxietyBorderline anxietyDepression ScaleDoctor's adviceChinese MSMChinese menSymptom severityHIVAnxiety scores
2016
Integrated prevention of mother-to-child HIV transmission services, antiretroviral therapy initiation, and maternal and infant retention in care in rural north-central Nigeria: a cluster-randomised controlled trial
Aliyu MH, Blevins M, Audet CM, Kalish M, Gebi UI, Onwujekwe O, Lindegren ML, Shepherd BE, Wester CW, Vermund SH. Integrated prevention of mother-to-child HIV transmission services, antiretroviral therapy initiation, and maternal and infant retention in care in rural north-central Nigeria: a cluster-randomised controlled trial. The Lancet HIV 2016, 3: e202-e211. PMID: 27126487, PMCID: PMC4852280, DOI: 10.1016/s2352-3018(16)00018-7.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAdolescentAdultAnti-HIV AgentsCD4 Lymphocyte CountDelivery of Health Care, IntegratedEarly Intervention, EducationalFamilyFemaleHIV InfectionsHumansInfantInfectious Disease Transmission, VerticalMaleMothersNevirapineNigeriaPregnancyPregnancy Complications, InfectiousPrenatal CareRural PopulationYoung AdultConceptsChild HIV transmissionAntiretroviral therapyStandard of careRural North-Central NigeriaWeeks post partumIntervention groupAntiretroviral prophylaxisEligible womenHIV statusHIV transmissionSecondary level health care facilitiesChild HIV transmission servicesClinical stage 1 diseasePost partumEunice Kennedy Shriver National InstituteMedian CD4 countPMTCT service deliveryAntiretroviral therapy initiationCD4 cell countPrevention of motherStage 1 diseaseUnknown HIV statusElimination of motherNorth Central NigeriaEarly infant diagnosis
2015
Predictors of antiretroviral therapy initiation: a cross-sectional study among Chinese HIV-infected men who have sex with men
Liu Y, Ruan Y, Vermund SH, Osborn CY, Wu P, Jia Y, Shao Y, Qian HZ. Predictors of antiretroviral therapy initiation: a cross-sectional study among Chinese HIV-infected men who have sex with men. BMC Infectious Diseases 2015, 15: 570. PMID: 26714889, PMCID: PMC4696158, DOI: 10.1186/s12879-015-1309-x.Peer-Reviewed Original ResearchConceptsCells/μLAntiretroviral therapy initiationART initiationHIV infectionCross-sectional studyTherapy initiationChinese MSMWorld Health Organization (WHO) clinical stage III/IVClinical stage III/IVStage III/IVNational HIV treatment guidelinesCD4 cell countHIV treatment guidelinesHIV viral suppressionLonger durationLogistic regression modelsChinese HIVEligible HIVCD4 countHIV careViral suppressionART eligibilityMedian durationTreatment guidelinesClinical symptomsPractical Management of HIV-Associated Anemia in Resource-Limited Settings: Prospective Observational Evaluation of a New Mozambican Guideline
Brentlinger PE, Silva WP, Vermund SH, Valverde E, Buene M, Moon TD. Practical Management of HIV-Associated Anemia in Resource-Limited Settings: Prospective Observational Evaluation of a New Mozambican Guideline. AIDS Research And Human Retroviruses 2015, 32: 12-25. PMID: 26178574, PMCID: PMC4692124, DOI: 10.1089/aid.2015.0030.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnemiaAnthelminticsAnti-HIV AgentsAntimalarialsAntitubercular AgentsCD4 Lymphocyte CountCoinfectionDeveloping CountriesDisease ManagementFemaleHelminthiasisHemoglobinsHIV InfectionsHumansLost to Follow-UpMalaria, FalciparumMaleMozambiquePractice Guidelines as TopicProspective StudiesRural PopulationTuberculosis, PulmonaryConceptsHIV-associated anemiaAdverse drug reactionsDrug reactionsHemoglobin responseGuideline revisionsIron deficiencyLower body mass indexCo-trimoxazole prophylaxisDiscontinuation of zidovudineLaboratory-confirmed malariaProspective observational evaluationRural Zambézia ProvinceT-cell countsT-lymphocyte countsSmear-positive tuberculosisBody mass indexResource limited settingsResource-limited settingsLogistic regression modelsAnaemic HIVStudy cliniciansAntiretroviral therapyEsophageal candidiasisPresumptive treatmentAnemia managementPregnant women with HIV in rural Nigeria have higher rates of antiretroviral treatment initiation, but similar loss to follow-up as non-pregnant women and men
Aliyu MH, Blevins M, Megazzini KM, Parrish DD, Audet CM, Chan N, Odoh C, Gebi UI, Muhammad MY, Shepherd BE, Wester CW, Vermund SH. Pregnant women with HIV in rural Nigeria have higher rates of antiretroviral treatment initiation, but similar loss to follow-up as non-pregnant women and men. International Health 2015, 7: 405-411. PMID: 26012740, PMCID: PMC4654753, DOI: 10.1093/inthealth/ihv032.Peer-Reviewed Original ResearchConceptsNon-pregnant womenPregnant womenPregnancy statusCumulative incidenceART-naïve patientsEarly ART initiationPost-ART initiationAntiretroviral therapy initiationDays of enrollmentART-naïve HIVAntiretroviral treatment initiationRural NigeriaART initiationHigher CD4Therapy initiationTreatment initiationClinical stageCox regressionPatient groupPregnant clientsHIVLTFUWomenHigh rateSexPrevalence and risk factors of cervical squamous intraepithelial lesions among HIV-infected women in Dar es Salaam, Tanzania
Liu E, McCree R, Mtisi E, Fawzi WW, Aris E, Lema IA, Hertzmark E, Chalamilla G, Li N, Vermund SH, Spiegelman D. Prevalence and risk factors of cervical squamous intraepithelial lesions among HIV-infected women in Dar es Salaam, Tanzania. International Journal Of STD & AIDS 2015, 27: 219-225. PMID: 25957324, PMCID: PMC11340030, DOI: 10.1177/0956462415584466.Peer-Reviewed Original ResearchConceptsCervical squamous intraepithelial lesionsSquamous intraepithelial lesionsHIV disease stageCell countIntraepithelial lesionsDisease stageHigh-grade squamous intraepithelial lesionsAdvanced HIV disease stageCervical cancer prevention servicesLow CD4 cell countsCD4 cell countCancer prevention servicesCross-sectional studyResource-limited settingsCervical inflammationLow CD4Median CD4HIV careMedian ageCervical screeningPapanicolaou smearsRisk factorsTreatment clinicsPrevention servicesHIVEnrolment trends in a comprehensive HIV programme in rural north-central Nigeria: improved care indices, but declining quality of clinical data over time
Aliyu MH, Blevins M, Arinze F, Megazzini KM, Bussell S, Dunlap J, Odoh C, Gebi UI, Muhammad MY, Shepherd BE, Audet CM, Vermund SH, Wester CW. Enrolment trends in a comprehensive HIV programme in rural north-central Nigeria: improved care indices, but declining quality of clinical data over time. Pathogens And Global Health 2015, 109: 75-83. PMID: 25822098, PMCID: PMC4571821, DOI: 10.1179/2047773215y.0000000007.Peer-Reviewed Original ResearchConceptsComprehensive HIV programsHIV programsComprehensive HIV/AIDS servicesCell countAdvanced clinical diseaseClinical stage INorth Central NigeriaHIV/AIDS servicesRural North-Central NigeriaQuality improvement effortsMedian CD4Clinical stagingMedian ageHIV servicesCare indexClinical dataClinical diseaseStage IAIDS servicesPatientsWindow periodHemoglobin dataClinical servicesEnrollment yearCells/
2014
Management of Fever in Ambulatory HIV-Infected Adults in Resource-Limited Settings
Brentlinger PE, Silva WP, Buene M, Morais L, Valverde E, Vermund SH, Moon TD. Management of Fever in Ambulatory HIV-Infected Adults in Resource-Limited Settings. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2014, 67: 304-309. PMID: 25314251, PMCID: PMC5844466, DOI: 10.1097/qai.0000000000000304.Peer-Reviewed Original ResearchMeSH KeywordsAdultAIDS-Related Opportunistic InfectionsAmbulatory CareAnti-Bacterial AgentsAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveBacterial InfectionsCD4 Lymphocyte CountDisease ManagementFemaleFeverHIV InfectionsHumansMaleMultivariate AnalysisOutcome Assessment, Health CarePractice Guidelines as TopicProspective StudiesRisk FactorsViral LoadConceptsManagement of feverLow CD4 T-lymphocyte countCD4 T-lymphocyte countLower body mass indexBacterial blood stream infectionsSpecific alternative diagnosesT-lymphocyte countsHistory of feverProspective observational studyBlood stream infectionsBody mass indexResource limited settingsAmbulatory HIVAntiretroviral therapyMalaria testingLower hemoglobinMass indexAdverse outcomesAlternative diagnosesObservational studyAxillary temperatureGuideline performanceMultivariate analysisHIVFeverCurrent drug use and lack of HIV virologic suppression: point-of-care urine drug screen versus self-report
Qian HZ, Mitchell VJ, Bebawy S, Cassell H, Perez G, McGowan CC, Sterling TR, Vermund SH, D’Aquila R, Hulgan T. Current drug use and lack of HIV virologic suppression: point-of-care urine drug screen versus self-report. BMC Infectious Diseases 2014, 14: 508. PMID: 25234368, PMCID: PMC4175271, DOI: 10.1186/1471-2334-14-508.Peer-Reviewed Original ResearchConceptsUrine drug screensCurrent drug usePositive urine drug screenComputer Assisted Self-InterviewVirologic suppressionDrug useAntiretroviral therapyDrug screensNegative urine drug screensHigher CD4 countsHIV disease progressionRoutine clinic visitsHIV virologic suppressionCross-sectional studyLower self-reported ratesSelf-reported ratesCD4 countClinic visitsPrognostic informationDisease progressionCaucasian raceART usersLower likelihoodResultsAbout halfSelf interviewCorrelates of Suboptimal Entry Into Early Infant Diagnosis in Rural North Central Nigeria
Aliyu MH, Blevins M, Megazzini KM, Audet CM, Dunlap J, Sodangi IS, Gebi UI, Shepherd BE, Wester CW, Vermund SH. Correlates of Suboptimal Entry Into Early Infant Diagnosis in Rural North Central Nigeria. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2014, 67: e19-e26. PMID: 24853310, PMCID: PMC4134378, DOI: 10.1097/qai.0000000000000215.Peer-Reviewed Original ResearchConceptsEarly infant diagnosisRural North-Central NigeriaInfant diagnosisPregnant womenChild HIV transmission (PMTCT) programsHIV care/treatmentClinic of enrolmentPediatric HIV infectionPrevention of motherNorth Central NigeriaMultivariable logistic regressionCare/treatmentDate of enrollmentHIV service uptakeEID uptakeCohort studyHIV infectionLaboratory variablesClinic locationService uptakeMaternal factorsTransmission programInfantsReferral sourceLogistic regressionRisk Factors for Delayed Initiation of Combination Antiretroviral Therapy in Rural North Central Nigeria
Aliyu MH, Blevins M, Parrish DD, Megazzini KM, Gebi UI, Muhammad MY, Ahmed ML, Hassan A, Shepherd BE, Vermund SH, Wester CW. Risk Factors for Delayed Initiation of Combination Antiretroviral Therapy in Rural North Central Nigeria. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2014, 65: e41-e49. PMID: 23727981, PMCID: PMC3818360, DOI: 10.1097/qai.0b013e31829ceaec.Peer-Reviewed Original ResearchConceptsCombination antiretroviral therapyAntiretroviral therapyDate of enrollmentART initiationCD4 countFunctional statusInitiation of ARTMedian CD4 countHigher CD4 countsLower functional statusMonths of enrollmentBody mass indexART eligibility criteriaAdults/adolescentsRural North-Central NigeriaHIV/AIDSQuality improvement effortsEligible HIVEligible patientsPatient characteristicsART uptakeMass indexRisk factorsTimely initiationDelayed initiation
2013
Impact of HIV drug resistance on virologic and immunologic failure and mortality in a cohort of patients on antiretroviral therapy in China
Liao L, Xing H, Su B, Wang Z, Ruan Y, Wang X, Liu Z, Lu Y, Yang S, Zhao Q, Vermund SH, Chen RY, Shao Y. Impact of HIV drug resistance on virologic and immunologic failure and mortality in a cohort of patients on antiretroviral therapy in China. AIDS 2013, 27: 1815-1824. PMID: 23803794, PMCID: PMC3694318, DOI: 10.1097/qad.0b013e3283611931.Peer-Reviewed Original ResearchConceptsCombination antiretroviral therapyHIV drug resistanceImmunologic failureHigh mortalityVirologic failureAntiretroviral therapyEmergence of HIVDRBaseline CD4 cell countDrug resistanceCD4 cell countCohort of patientsSecond-line drugsEnd of studyProportional hazards modelRural Chinese countiesHIVDR mutationsMedian timePatient adherenceKaplan-MeierChinese patientsRisk factorsHazards modelPatientsCell countMortalityOptimizing PMTCT service delivery in rural North-Central Nigeria: Protocol and design for a cluster randomized study
Aliyu MH, Blevins M, Audet C, Shepherd BE, Hassan A, Onwujekwe O, Gebi UI, Kalish M, Lindegren ML, Vermund SH, Wester CW. Optimizing PMTCT service delivery in rural North-Central Nigeria: Protocol and design for a cluster randomized study. Contemporary Clinical Trials 2013, 36: 187-197. PMID: 23816493, PMCID: PMC3786261, DOI: 10.1016/j.cct.2013.06.013.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Retroviral AgentsCD4 Lymphocyte CountCost-Benefit AnalysisFamilyFemaleHIV InfectionsHumansInfantInfant, NewbornInfectious Disease Transmission, VerticalMaternal-Child Health CentersMentorsNigeriaPatient SatisfactionPoint-of-Care SystemsPregnancyPrenatal CareResearch DesignRural PopulationSocioeconomic FactorsConceptsAntiretroviral therapyPMTCT servicesChild transmissionHIV service integrationPMTCT service deliveryPMTCT service provisionChild HIV transmissionPrevention of motherCell count testingSimilar resource-limited settingsRural health facilitiesRural North-Central NigeriaResource-limited settingsPatient care responsibilitiesPMTCT careMore HIVHIV infectionCare CD4Cell count resultsHIV transmissionPregnant womenUNAIDS/Health facilitiesHealth providersInfluential community members
2012
Availability of Volunteer-Led Home-Based Care System and Baseline Factors as Predictors of Clinical Outcomes in HIV-Infected Patients in Rural Zambia
Estopinal CB, van Dijk JH, Sitali S, Stewart H, Davidson MA, Spurrier J, Vermund SH. Availability of Volunteer-Led Home-Based Care System and Baseline Factors as Predictors of Clinical Outcomes in HIV-Infected Patients in Rural Zambia. PLOS ONE 2012, 7: e49564. PMID: 23236351, PMCID: PMC3517597, DOI: 10.1371/journal.pone.0049564.Peer-Reviewed Original ResearchConceptsBody mass indexHome-based careLower body mass indexART initiationAntiretroviral therapyUnfavorable outcomeTreatment outcomesFavorable outcomeRural Southern ProvinceCell countRetrospective cohort studyImproved treatment outcomesEligible patientsHBC programmesLow CD4HIV careAdherence counselingCohort studyDate of birthBaseline factorsMedical chartsBivariable analysisClinical outcomesMass indexMultivariable analysisHPV Genotype Distribution in Cervical Intraepithelial Neoplasia among HIV-Infected Women in Pune, India
Mane A, Nirmalkar A, Risbud AR, Vermund SH, Mehendale SM, Sahasrabuddhe VV. HPV Genotype Distribution in Cervical Intraepithelial Neoplasia among HIV-Infected Women in Pune, India. PLOS ONE 2012, 7: e38731. PMID: 22723879, PMCID: PMC3378535, DOI: 10.1371/journal.pone.0038731.Peer-Reviewed Original ResearchConceptsCarcinogenic HPV genotypesHPV genotypesLow CD4HPV infectionCIN3 lesionsCommon HPV genotypesHPV genotype distributionMultiple HPV genotypesCombination antiretroviral therapyCervical intraepithelial neoplasiaCarcinogenic HPV infectionHalf of womenQuarter of womenHPV type detectionLifetime sexual partnersCarcinogenic HPVHPV16 detectionAntiretroviral therapyHPV genotypingComposite endpointOrder of prevalenceIntraepithelial neoplasiaCervical cancerHPV 16Observational study
2011
Enrolment and programmatic trends and predictors of antiretroviral therapy initiation from President's Emergency Plan for AIDS Relief (PEPFAR)-supported public HIV care and treatment sites in rural Mozambique
Moon TD, Burlison JR, Blevins M, Shepherd BE, Baptista A, Sidat M, Vergara AE, Vermund SH. Enrolment and programmatic trends and predictors of antiretroviral therapy initiation from President's Emergency Plan for AIDS Relief (PEPFAR)-supported public HIV care and treatment sites in rural Mozambique. International Journal Of STD & AIDS 2011, 22: 621-627. PMID: 22096045, DOI: 10.1258/ijsa.2011.010442.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyART initiationAntiretroviral therapy initiationHIV treatment programsCells/μLContinuous drug supplyPresident's Emergency PlanHIV careTherapy initiationHIV testingMedian ageSaharan AfricaTreatment expansionZambézia ProvinceRoutine dataPatient record systemPatientsTreatment programOlder ageAIDS ReliefHealth manpowerCells/Drug supplyRecord systemTreatment sitesTesting and linkage of patients to early care
Vermund SH. Testing and linkage of patients to early care. AIDS 2011, 25: 1547-1548. PMID: 21747236, DOI: 10.1097/qad.0b013e32834940b3.Peer-Reviewed Original Research