2023
Age-dependent impairment in antibody responses elicited by a homologous CoronaVac booster dose
Filardi B, Monteiro V, Schwartzmann P, do Prado Martins V, Zucca L, Baiocchi G, Malik A, Silva J, Hahn A, Chen N, Pham K, Pérez-Then E, Miric M, Brache V, Cochon L, Larocca R, Della Rosa Mendez R, Silveira D, Pinto A, Croda J, Yildirim I, Omer S, Ko A, Vermund S, Grubaugh N, Iwasaki A, Lucas C, Initiative Y, Vogels C, Breban M, Koch T, Chaguza C, Tikhonova I, Castaldi C, Mane S, De Kumar B, Ferguson D, Kerantzas N, Peaper D, Landry M, Schulz W. Age-dependent impairment in antibody responses elicited by a homologous CoronaVac booster dose. Science Translational Medicine 2023, 15: eade6023. PMID: 36791210, DOI: 10.1126/scitranslmed.ade6023.Peer-Reviewed Original ResearchMeSH KeywordsAgedAntibodies, ViralAntibody FormationBNT162 VaccineCOVID-19HumansImmunoglobulin GSARS-CoV-2ConceptsBooster doseAntibody responseNeutralization titersVirus-specific IgG titersOlder adultsAntiviral humoral immunityPlasma antibody responsesHigh-risk populationSARS-CoV-2 spikeYears of ageAge-dependent impairmentHeterologous regimensBooster dosesBooster vaccineCoronaVac vaccineIgG titersProtective immunityHumoral immunityHumoral responseCoronaVacOmicron waveBooster strategyAge groupsEarly controlVaccineCOVID-19 vaccine equity in Africa
Turyasingura N, James W, Vermund S. COVID-19 vaccine equity in Africa. Transactions Of The Royal Society Of Tropical Medicine And Hygiene 2023, 117: 470-472. PMID: 36622662, PMCID: PMC10235805, DOI: 10.1093/trstmh/trac130.Peer-Reviewed Original ResearchConceptsVaccine equitySevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Severe COVID-19 infectionRespiratory syndrome coronavirus 2Coronavirus disease 2019 (COVID-19) pandemicSyndrome coronavirus 2COVID-19 vaccination ratesCOVID-19 infectionDisease 2019 pandemicLower COVID-19 vaccination ratesCoronavirus 2Vaccination ratesVaccine developmentVaccine distributionGlobal health discourseHealth discourseHigh-income nationsHospitalizationInfection
2022
Risk of SARS-CoV-2 reinfection: a systematic review and meta-analysis
Deng L, Li P, Zhang X, Jiang Q, Turner D, Zhou C, Gao Y, Qian F, Zhang C, Lu H, Zou H, Vermund S, Qian H. Risk of SARS-CoV-2 reinfection: a systematic review and meta-analysis. Scientific Reports 2022, 12: 20763. PMID: 36456577, PMCID: PMC9714387, DOI: 10.1038/s41598-022-24220-7.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 reinfectionSystematic reviewReinfection incidenceHazard ratioCase reportIncidence ratePrior SARS-CoV-2 infectionSARS-CoV-2 infectionIncidence of reinfectionInfection-naïve individualsRisk of reinfectionSARS-CoV-2 variantsRandom-effects modelSARS-CoV-2Web of ScienceCohort studyReinfection riskReinfection casesPrior infectionLower riskNew infectionsOmicron variantReinfectionInfection incidenceIncidenceNo evidence of fetal defects or anti-syncytin-1 antibody induction following COVID-19 mRNA vaccination
Lu-Culligan A, Tabachnikova A, Pérez-Then E, Tokuyama M, Lee HJ, Lucas C, Monteiro V, Miric M, Brache V, Cochon L, Muenker MC, Mohanty S, Huang J, Kang I, Dela Cruz C, Farhadian S, Campbell M, Yildirim I, Shaw AC, Ma S, Vermund SH, Ko AI, Omer SB, Iwasaki A. No evidence of fetal defects or anti-syncytin-1 antibody induction following COVID-19 mRNA vaccination. PLOS Biology 2022, 20: e3001506. PMID: 35609110, PMCID: PMC9129011, DOI: 10.1371/journal.pbio.3001506.Peer-Reviewed Original ResearchConceptsCOVID-19 mRNA vaccinationMRNA vaccinationEarly pregnancyFetal sizeCoronavirus disease 2019 (COVID-19) mRNA vaccinationSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Respiratory syndrome coronavirus 2Maternal antibody statusAdverse neonatal outcomesSyndrome coronavirus 2Birth defectsPolyinosinic-polycytidylic acidCrown-rump lengthGross birth defectsUnvaccinated adultsMaternal illnessNeonatal outcomesVaccinated adultsAntibody statusTLR3 agonistEarly immunizationMurine pregnancyAntibody inductionCoronavirus 2COVID-19 Clinical Presentation Among HIV-Infected Persons in China: A Systematic Review
Huang D, Zunong J, Li M, Li D, Gong J, Vermund SH, Hu Y. COVID-19 Clinical Presentation Among HIV-Infected Persons in China: A Systematic Review. Current HIV/AIDS Reports 2022, 19: 167-176. PMID: 35394249, PMCID: PMC8990500, DOI: 10.1007/s11904-022-00606-0.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyCOVID-19 clinical severityCOVID-19 clinical presentationCOVID-19Undetectable viral loadAsymptomatic COVID-19Severe COVID-19Last clinical visitCase series/reportsCase fatality rateCOVID-19 prognosisLate antiretroviral therapyIL-6 resultsSARS-CoV-2COVID-19 diagnosisMedian CD4Gastrointestinal symptomsHIV infectionMedian ageRespiratory distressClinical featuresClinical presentationClinical visitsViral loadClinical detailsIntersecting Pandemics of HIV and SARS-CoV-2: Commentary on the Special Issue
Vermund SH. Intersecting Pandemics of HIV and SARS-CoV-2: Commentary on the Special Issue. Current HIV/AIDS Reports 2022, 19: 1-4. PMID: 35192108, PMCID: PMC8862004, DOI: 10.1007/s11904-022-00599-w.Peer-Reviewed Original ResearchSchool closures and reopenings during the COVID-19 pandemic: a scoping review protocol
Li D, Nyhan K, Zhou X, Zhu Y, Castro D, Vermund SH, Brault M. School closures and reopenings during the COVID-19 pandemic: a scoping review protocol. BMJ Open 2022, 12: e054292. PMID: 35110320, PMCID: PMC8811274, DOI: 10.1136/bmjopen-2021-054292.Peer-Reviewed Original ResearchConceptsSchool closuresCOVID-19 pandemicWidespread school closuresCitation chainingType of researchSchool safetySchool reopeningSchoolsIndependent third reviewerPaucity of researchCollege studentsSources of evidenceJoanna Briggs Institute methodologyIndividual knowledgePandemicTitle screeningIndividual concernsCOVID-19 evidenceDisease prevention practicesGrey literatureFormal ethical approvalFull-text screeningBroad disseminationTeachersReopeningNeutralizing antibodies against the SARS-CoV-2 Delta and Omicron variants following heterologous CoronaVac plus BNT162b2 booster vaccination
Pérez-Then E, Lucas C, Monteiro VS, Miric M, Brache V, Cochon L, Vogels CBF, Malik AA, De la Cruz E, Jorge A, De los Santos M, Leon P, Breban MI, Billig K, Yildirim I, Pearson C, Downing R, Gagnon E, Muyombwe A, Razeq J, Campbell M, Ko AI, Omer SB, Grubaugh ND, Vermund SH, Iwasaki A. Neutralizing antibodies against the SARS-CoV-2 Delta and Omicron variants following heterologous CoronaVac plus BNT162b2 booster vaccination. Nature Medicine 2022, 28: 481-485. PMID: 35051990, PMCID: PMC8938264, DOI: 10.1038/s41591-022-01705-6.Peer-Reviewed Original ResearchConceptsTwo-dose regimenOmicron variantVaccine boosterMRNA vaccinesNeutralization activityDelta variantTwo-dose mRNA vaccinesVirus-specific antibody levelsSARS-CoV-2 Omicron variantMRNA vaccine boosterNeutralization of OmicronNumerous spike mutationsSARS-CoV-2 DeltaPotent neutralization activityInfection-induced immunityCOVID-19 vaccineBNT162b2 boosterBooster vaccinationPrime vaccinationAntibody levelsAntibody titersHumoral immunityImmune escapeInactivated vaccinesVaccine
2021
Leveraging HIV Care Infrastructures for Integrated Chronic Disease and Pandemic Management in Sub-Saharan Africa
Brault MA, Vermund SH, Aliyu MH, Omer SB, Clark D, Spiegelman D. Leveraging HIV Care Infrastructures for Integrated Chronic Disease and Pandemic Management in Sub-Saharan Africa. International Journal Of Environmental Research And Public Health 2021, 18: 10751. PMID: 34682492, PMCID: PMC8535610, DOI: 10.3390/ijerph182010751.Peer-Reviewed Original ResearchMeSH KeywordsAfrica South of the SaharaChronic DiseaseCOVID-19HIV InfectionsHumansPandemicsSARS-CoV-2ConceptsNon-communicable diseasesNon-communicable disease careInfectious diseasesHIV care infrastructureTropical infectious diseasesHIV/AIDS epidemicIntegrated service delivery modelCOVID-19Future pandemic threatsLow-cost interventionMinistry of HealthDisease careChronic diseasesCardiovascular diseaseSuch careIntegrated careAIDS ReliefHealth systemSub-Saharan AfricaDiseaseService delivery modelsPandemic threatAIDS epidemicCare infrastructureHealthcare modelSyndemic Framework Evaluation of Severe COVID-19 Outcomes in the United States: Factors Associated With Race and Ethnicity
Williams C, Vermund SH. Syndemic Framework Evaluation of Severe COVID-19 Outcomes in the United States: Factors Associated With Race and Ethnicity. Frontiers In Public Health 2021, 9: 720264. PMID: 34616705, PMCID: PMC8488144, DOI: 10.3389/fpubh.2021.720264.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infection riskSevere COVID-19 outcomesSevere clinical outcomesCOVID-19 outcomesSeverity of diseaseAssociated disease burdenCOVID-19Ethnic health inequalitiesIndividual clinical dataClinical care environmentLong-term careCoronavirus disease (COVID-19) pandemicClinical outcomesSyndemic factorsDisease burdenClinical dataHealthcare barriersHealth outcomesInfection riskHealth inequalitiesDisease pandemicSyndemic theoryVulnerable populationsCare environmentFuture pandemicsReopening Schools After a Novel Coronavirus Surge
Li D, Lin EZ, Brault MA, Paquette J, Vermund SH, Godri Pollitt KJ. Reopening Schools After a Novel Coronavirus Surge. Advances In Experimental Medicine And Biology 2021, 1318: 785-813. PMID: 33973212, DOI: 10.1007/978-3-030-63761-3_44.Peer-Reviewed Original ResearchConceptsCoronavirus disease 2019 (COVID-19) pandemicDisease 2019 pandemicGlobal death tollMental health supportPandemic influenzaDisease controlHealth supportSocial isolationNew guidelinesVulnerability of childrenRisk reductionRiskDisease control strategiesSafetyChild safetySpecial considerationDeath tollOpening schoolsPandemic
2020
African Physician Migration to High-Income Nations: Diverse Motives to Emigrate (“We Are not Florence Nightingale”) or Stay in Africa (“There Is No Place Like Home”); Comment on “Doctor Retention: A Cross-sectional Study of How Ireland Has Been Losing the Battle”
Tankwanchi AS, Hagopian A, Vermund SH. African Physician Migration to High-Income Nations: Diverse Motives to Emigrate (“We Are not Florence Nightingale”) or Stay in Africa (“There Is No Place Like Home”); Comment on “Doctor Retention: A Cross-sectional Study of How Ireland Has Been Losing the Battle”. International Journal Of Health Policy And Management 2020, 0: 660-663. PMID: 33160297, PMCID: PMC9278531, DOI: 10.34172/ijhpm.2020.219.Peer-Reviewed Original ResearchHow coronavirus disease 2019 entered Africa and the Middle East: a case study from Egypt
Khattab NM, Vermund SH, Hu Y. How coronavirus disease 2019 entered Africa and the Middle East: a case study from Egypt. Transactions Of The Royal Society Of Tropical Medicine And Hygiene 2020, 114: 715-717. PMID: 32785588, PMCID: PMC7454931, DOI: 10.1093/trstmh/traa065.Peer-Reviewed Original ResearchCoinfection With HIV and SARS-CoV-2 in Wuhan, China: A 12-Person Case Series
Hu Y, Ma J, Huang H, Vermund SH. Coinfection With HIV and SARS-CoV-2 in Wuhan, China: A 12-Person Case Series. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2020, 85: 10.1097/qai.0000000000002424. PMID: 32568771, PMCID: PMC7446977, DOI: 10.1097/qai.0000000000002424.Peer-Reviewed Original ResearchConceptsAntiretroviral therapySARS-CoV-2Clinical improvementCase seriesLong-term antiretroviral therapyMild COVID-19 symptomsCOVID-19 coinfectionAcute COVID-19COVID-19 symptomsYears of ageCOVID-19Health care servicesPossible COVID-19 casesCoinfected PersonsAntiretroviral medicationsMedian ageIntensive careCOVID-19 casesClinical prognosisFavorable outcomeSevere symptomsAdditional casesCare servicesHIVInformed consentUS withdrawal from WHO is unlawful and threatens global and US health and security
Gostin LO, Koh HH, Williams M, Hamburg MA, Benjamin G, Foege WH, Davidson P, Bradley EH, Barry M, Koplan JP, Periago MFR, El Sadr W, Kurth A, Vermund SH, Kavanagh MM. US withdrawal from WHO is unlawful and threatens global and US health and security. The Lancet 2020, 396: 293-295. PMID: 32653080, PMCID: PMC7346815, DOI: 10.1016/s0140-6736(20)31527-0.Peer-Reviewed Original ResearchSocial Distancing among Medical Students during the 2019 Coronavirus Disease Pandemic in China: Disease Awareness, Anxiety Disorder, Depression, and Behavioral Activities
Xiao H, Shu W, Li M, Li Z, Tao F, Wu X, Yu Y, Meng H, Vermund SH, Hu Y. Social Distancing among Medical Students during the 2019 Coronavirus Disease Pandemic in China: Disease Awareness, Anxiety Disorder, Depression, and Behavioral Activities. International Journal Of Environmental Research And Public Health 2020, 17: 5047. PMID: 32674285, PMCID: PMC7399842, DOI: 10.3390/ijerph17145047.Peer-Reviewed Original ResearchConceptsMultivariable logistic regressionAnxiety disordersAnxiety disorder/depressionLogistic regressionNation-wide cross-sectional surveyGeneralized Anxiety Disorder-7Anxiety Disorder-7Cross-sectional surveySelf-administered questionnaireCoronavirus disease (COVID-19) pandemicMedical students' knowledgeQuestionnaire-9Medical studentsDisease awarenessSocial distancingCoronavirus diseaseDisease controlViral spreadCOVID-19 awarenessDisease pandemicPsychological supportDepressionDisordersDaily handwashingSocial distancing measuresAsymptomatic Transmission and the Infection Fatality Risk for COVID-19: Implications for School Reopening
Vermund SH, Pitzer VE. Asymptomatic Transmission and the Infection Fatality Risk for COVID-19: Implications for School Reopening. Clinical Infectious Diseases 2020, 72: 1493-1496. PMID: 32584967, PMCID: PMC7337644, DOI: 10.1093/cid/ciaa855.Peer-Reviewed Original Research