1982
Granulomatous lymphangitis. A complication of intralymphatic immunotherapy with methanol extraction residue of BCG (MER)
Kirkwood J, Ariyan S, Nordlund J, Forget B. Granulomatous lymphangitis. A complication of intralymphatic immunotherapy with methanol extraction residue of BCG (MER). Cancer 1982, 50: 1299-1303. PMID: 7104973, DOI: 10.1002/1097-0142(19821001)50:7<1299::aid-cncr2820500714>3.0.co;2-#.Peer-Reviewed Original ResearchConceptsBacille Calmette-GuerinMethanol extraction residueCalmette-GuerinThick primary melanomasDefinitive surgical excisionAdjuvant therapyIntralymphatic immunotherapyRegional metastasesRecurrent melanomaRegional nodalClinical presentationSurgical excisionAdjuvant agentLocal instillationIntralymphatic injectionsPrimary tumorPrimary melanomaAntitumor effectsGranulomatous lymphangitisExperimental animalsSubstantial riskComplicationsThick primariesImmunotherapyTherapy
1980
An Experimental Model to Determine the Effects of Adjuvant Therapy on the Incidence of Postoperative Wound Infection
Ariyan S, Marfuggi R, Harder G, Goodie M, Schobinger R. An Experimental Model to Determine the Effects of Adjuvant Therapy on the Incidence of Postoperative Wound Infection. Plastic & Reconstructive Surgery 1980, 65: 328-337. PMID: 6766558, DOI: 10.1097/00006534-198003000-00009.Peer-Reviewed Original ResearchConceptsPreoperative radiationDose of radiationPostoperative wound infectionQuantitative bacterial countsRate of infectionAdjuvant therapyPostoperative radiationDoses of radiationSurgical infectionsWound infectionSurgical woundsNeck areaS. aureus organismsVirulent organismsNormal tissuesExperimental modelTissue resistanceInfectionRatsWoundsDoseDosesBacterial contaminationBacterial countsTissueAn Experimental Model to Determine the Effects of Adjuvant Therapy on the Incidence of Postoperative Wound Infection
Ariyan S, Kraft R, Goldberg N, Lawrie H. An Experimental Model to Determine the Effects of Adjuvant Therapy on the Incidence of Postoperative Wound Infection. Plastic & Reconstructive Surgery 1980, 65: 338-345. PMID: 6766559, DOI: 10.1097/00006534-198003000-00010.Peer-Reviewed Original ResearchConceptsWound infectionPostoperative wound infectionUse of methotrexateNormal wound healingLeucovorin treatmentPreoperative adjuvantAdjuvant therapyAdjuvant treatmentNeck cancerSurgical removalSurgical woundsRadiation therapyLD50 doseLarge dosesExperimental modelWound healingTherapyInfectionReasonable approachBacterial contaminationTreatmentOptimal timeMethotrexateAdjuvantMTX