1984
An Experimental Model to Determine the Level of Antibiotics in Irradiated Tissues
Cruz N, Ariyan S, Miniter P, Andriole V. An Experimental Model to Determine the Level of Antibiotics in Irradiated Tissues. Plastic & Reconstructive Surgery 1984, 73: 811-816. PMID: 6718579, DOI: 10.1097/00006534-198405000-00015.Peer-Reviewed Original ResearchConceptsMicrograms/Antibiotic levelsMale Sprague-Dawley ratsSprague-Dawley ratsIrradiated tissuesArea of skinSingle doseTherapeutic dosesIntraperitoneal administrationGentamicin levelsGrowth inhibition assaysNormal skinSkin homogenatesSkin areasExperimental modelSoft tissueWeeksSkinInhibition assaysRatsGentamicinTissueDoseDosesLevels of antibiotics
1980
An Experimental Model to Determine the Effects of Adjuvant Therapy on the Incidence of Postoperative Wound Infection
Ariyan S, Marfuggi R, Harder G, Goodie M, Schobinger R. An Experimental Model to Determine the Effects of Adjuvant Therapy on the Incidence of Postoperative Wound Infection. Plastic & Reconstructive Surgery 1980, 65: 328-337. PMID: 6766558, DOI: 10.1097/00006534-198003000-00009.Peer-Reviewed Original ResearchConceptsPreoperative radiationDose of radiationPostoperative wound infectionQuantitative bacterial countsRate of infectionAdjuvant therapyPostoperative radiationDoses of radiationSurgical infectionsWound infectionSurgical woundsNeck areaS. aureus organismsVirulent organismsNormal tissuesExperimental modelTissue resistanceInfectionRatsWoundsDoseDosesBacterial contaminationBacterial countsTissueAn Experimental Model to Determine the Effects of Adjuvant Therapy on the Incidence of Postoperative Wound Infection
Ariyan S, Kraft R, Goldberg N, Lawrie H. An Experimental Model to Determine the Effects of Adjuvant Therapy on the Incidence of Postoperative Wound Infection. Plastic & Reconstructive Surgery 1980, 65: 338-345. PMID: 6766559, DOI: 10.1097/00006534-198003000-00010.Peer-Reviewed Original ResearchConceptsWound infectionPostoperative wound infectionUse of methotrexateNormal wound healingLeucovorin treatmentPreoperative adjuvantAdjuvant therapyAdjuvant treatmentNeck cancerSurgical removalSurgical woundsRadiation therapyLD50 doseLarge dosesExperimental modelWound healingTherapyInfectionReasonable approachBacterial contaminationTreatmentOptimal timeMethotrexateAdjuvantMTX