An Experimental Model to Determine the Effects of Adjuvant Therapy on the Incidence of Postoperative Wound Infection
Ariyan S, Kraft R, Goldberg N, Lawrie H. An Experimental Model to Determine the Effects of Adjuvant Therapy on the Incidence of Postoperative Wound Infection. Plastic & Reconstructive Surgery 1980, 65: 338-345. PMID: 6766559, DOI: 10.1097/00006534-198003000-00010.Peer-Reviewed Original ResearchConceptsWound infectionPostoperative wound infectionUse of methotrexateNormal wound healingLeucovorin treatmentPreoperative adjuvantAdjuvant therapyAdjuvant treatmentNeck cancerSurgical removalSurgical woundsRadiation therapyLD50 doseLarge dosesExperimental modelWound healingTherapyInfectionReasonable approachBacterial contaminationTreatmentOptimal timeMethotrexateAdjuvantMTX