1982
Intralymphatic and regional surgical adjuvant immunotherapy in high-risk melanoma of the extremities.
Ariyan S, Kirkwood J, Mitchell M, Nordlund J, Lerner A, Papac R. Intralymphatic and regional surgical adjuvant immunotherapy in high-risk melanoma of the extremities. Surgery 1982, 92: 459-63. PMID: 7112396.Peer-Reviewed Original ResearchConceptsBacillus Calmette-GuerinSurgical adjuvant immunotherapyMER-BCGAdjuvant immunotherapyControl groupHigh-risk malignant melanomaDisease-free survivalHigh-risk melanomaIntraoperative infiltrationImmunotherapy groupIntradermal vaccinationIntralymphatic immunotherapyRegional lymphadenectomyConsecutive patientsSurgical excisionCalmette-GuerinMalignant melanomaPatientsImmunotherapyMethanol-extractable residueLymphadenectomyRecurrenceMelanomaExtremitiesSame interval
1980
An Experimental Model to Determine the Effects of Adjuvant Therapy on the Incidence of Postoperative Wound Infection
Ariyan S, Marfuggi R, Harder G, Goodie M, Schobinger R. An Experimental Model to Determine the Effects of Adjuvant Therapy on the Incidence of Postoperative Wound Infection. Plastic & Reconstructive Surgery 1980, 65: 328-337. PMID: 6766558, DOI: 10.1097/00006534-198003000-00009.Peer-Reviewed Original ResearchConceptsPreoperative radiationDose of radiationPostoperative wound infectionQuantitative bacterial countsRate of infectionAdjuvant therapyPostoperative radiationDoses of radiationSurgical infectionsWound infectionSurgical woundsNeck areaS. aureus organismsVirulent organismsNormal tissuesExperimental modelTissue resistanceInfectionRatsWoundsDoseDosesBacterial contaminationBacterial countsTissueAn Experimental Model to Determine the Effects of Adjuvant Therapy on the Incidence of Postoperative Wound Infection
Ariyan S, Kraft R, Goldberg N, Lawrie H. An Experimental Model to Determine the Effects of Adjuvant Therapy on the Incidence of Postoperative Wound Infection. Plastic & Reconstructive Surgery 1980, 65: 338-345. PMID: 6766559, DOI: 10.1097/00006534-198003000-00010.Peer-Reviewed Original ResearchConceptsWound infectionPostoperative wound infectionUse of methotrexateNormal wound healingLeucovorin treatmentPreoperative adjuvantAdjuvant therapyAdjuvant treatmentNeck cancerSurgical removalSurgical woundsRadiation therapyLD50 doseLarge dosesExperimental modelWound healingTherapyInfectionReasonable approachBacterial contaminationTreatmentOptimal timeMethotrexateAdjuvantMTX