2022
Integrative molecular and clinical profiling of acral melanoma links focal amplification of 22q11.21 to metastasis
Farshidfar F, Rhrissorrakrai K, Levovitz C, Peng C, Knight J, Bacchiocchi A, Su J, Yin M, Sznol M, Ariyan S, Clune J, Olino K, Parida L, Nikolaus J, Zhang M, Zhao S, Wang Y, Huang G, Wan M, Li X, Cao J, Yan Q, Chen X, Newman AM, Halaban R. Integrative molecular and clinical profiling of acral melanoma links focal amplification of 22q11.21 to metastasis. Nature Communications 2022, 13: 898. PMID: 35197475, PMCID: PMC8866401, DOI: 10.1038/s41467-022-28566-4.Peer-Reviewed Original ResearchConceptsAcral melanomaMelanoma subtypesClinical profilingCommon melanoma subtypeImmune checkpoint blockadeCheckpoint blockadeInferior survivalMelanoma cell linesKey molecular driversPoor prognosisTherapeutic targetAnchorage-independent growthImmunomodulatory genesNon-white individualsHotspot mutationsMolecular driversCandidate oncogeneMelanomaApoptotic cell deathLZTR1Focal amplificationTumor promoterCell linesMetastasisTumor suppressor
2001
Surgical Considerations in the Management of Malignant Melanoma of the Ear
Narayan D, Ariyan S. Surgical Considerations in the Management of Malignant Melanoma of the Ear. Plastic & Reconstructive Surgery 2001, 107: 20-24. PMID: 11176596, DOI: 10.1097/00006534-200101000-00004.Peer-Reviewed Original ResearchConceptsMalignant melanomaLocal recurrenceYale-New Haven HospitalUnknown primary sitePrimary malignant melanomaPalpable nodesDisseminated diseaseRadical resectionConsecutive patientsLocal excisionRegional recurrenceWorse prognosisTransit melanomaConservative excisionSurgical considerationsSkin graftsDifficult lesionsFasciocutaneous flapPatientsPrimary siteMelanomaCosmetic importanceRecurrenceExternal earLesions
2000
Surgical Management Of The Primary Melanoma
Narayan D, Ariyan S. Surgical Management Of The Primary Melanoma. Clinics In Plastic Surgery 2000, 27: 409-419. PMID: 10941561, DOI: 10.1016/s0094-1298(20)32736-x.Peer-Reviewed Original ResearchRegional Lymph Node Dissections In Malignant Melanoma
Lawton G, Ariyan S. Regional Lymph Node Dissections In Malignant Melanoma. Clinics In Plastic Surgery 2000, 27: 431-440. PMID: 10941563, DOI: 10.1016/s0094-1298(20)32738-3.Peer-Reviewed Original ResearchConceptsElective lymph node dissectionLymph node dissectionNode dissectionNegative nodesTherapeutic lymph node dissectionRegional lymph node dissectionSentinel lymph node dissectionClinical stage ITime of resectionPositive nodesRegional lymphadenectomySentinel lymphProphylactic excisionCutaneous melanomaPrimary tumorMalignant melanomaPrimary melanomaRegional nodesSurvival advantageStage IPatientsMetastatic cellsMelanomaDissectionClear benefitLymphatic Mapping And Sentinel Lymph Node Biopsies
Ali-Salaam P, Ariyan S. Lymphatic Mapping And Sentinel Lymph Node Biopsies. Clinics In Plastic Surgery 2000, 27: 421-429. PMID: 10941562, DOI: 10.1016/s0094-1298(20)32737-1.Peer-Reviewed Original ResearchThe Use Of Isolated Limb Perfusion To Manage Recurrent Malignant Melanoma
Ma D, Ariyan S. The Use Of Isolated Limb Perfusion To Manage Recurrent Malignant Melanoma. Clinics In Plastic Surgery 2000, 27: 441-450. PMID: 10941564, DOI: 10.1016/s0094-1298(20)32739-5.Peer-Reviewed Original ResearchConceptsRecurrent malignant melanomaMalignant melanomaLimb perfusionTumor necrosis factor alphaRecurrent metastatic diseaseIsolated limb perfusionNecrosis factor alphaList of drugsHyperthermic ILPRecurrent diseaseMetastatic diseaseTumor loadLimb functionClinical trialsSurgical techniqueFactor alphaWound hygieneChemotherapeutic agentsMelanomaPerfusionDiseaseExtremitiesTreatmentHyperthermicTrials
1999
Follow‐up recommendations for patients with American Joint Committee on Cancer Stages I–III malignant melanoma
Poo‐Hwu W, Ariyan S, Lamb L, Papac R, Zelterman D, Hu G, Brown J, Fischer D, Bolognia J, Buzaid A. Follow‐up recommendations for patients with American Joint Committee on Cancer Stages I–III malignant melanoma. Cancer 1999, 86: 2252-2258. PMID: 10590365, DOI: 10.1002/(sici)1097-0142(19991201)86:11<2252::aid-cncr12>3.0.co;2-q.Peer-Reviewed Original ResearchConceptsCancer stage IAmerican Joint CommitteePatient education programStage IYale Melanoma UnitSurveillance scheduleSymptomatic recurrenceMelanoma UnitSurveillance examinationsJoint CommitteeOverall survival rateStage of diseaseDetection of recurrenceAsymptomatic recurrenceAsymptomatic patientsDistant recurrenceLocoregional recurrenceHazard ratioDisease recurrenceInitial visitMore recurrencesMost recurrencesLate recurrenceMelanoma patientsRecurrence group
1998
Safety and efficacy of isolated perfusion of extremities for recurrent tumor in elderly patients
Ariyan S, Poo W. Safety and efficacy of isolated perfusion of extremities for recurrent tumor in elderly patients. Surgery 1998, 123: 335-343. PMID: 9526527, DOI: 10.1016/s0039-6060(98)70188-6.Peer-Reviewed Original ResearchConceptsElderly patientsYounger patientsIsolated perfusionMeaningful disease controlRegional isolated perfusionEvidence of diseaseHigh-dose chemotherapySeries of patientsIsolated limb perfusionMajor surgical proceduresNumber of patientsDisease-free controlsYears of ageSalvage of limbsSignificant palliationThird perfusionAggressive treatmentDose chemotherapyOlder patientsRecurrent diseaseSurvival benefitTransit diseaseSerious complicationsRecurrent tumorsLimb perfusion
1997
Regional Isolated Perfusion of Extremities for Melanoma: A 20-Year Experience with Drugs Other than L-Phenylalanine Mustard
Ariyan S, Poo W, Bolognia J. Regional Isolated Perfusion of Extremities for Melanoma: A 20-Year Experience with Drugs Other than L-Phenylalanine Mustard. Plastic & Reconstructive Surgery 1997, 99: 1023-1029. PMID: 9091898, DOI: 10.1097/00006534-199704000-00016.Peer-Reviewed Original ResearchConceptsL-phenylalanine mustardRegional isolated perfusionIsolated limb perfusionIsolated perfusionLimb perfusionUpper extremityLower extremitiesTherapeutic isolated limb perfusionNonfatal pulmonary embolusRegional treatment modalityEvidence of diseaseHigh-dose chemotherapyHigh-risk melanomaNumber of patientsDifficult management problemDisease-free controlsTechnique of perfusionLimb recurrenceMeaningful palliationRepeat perfusionsAggressive treatmentPulmonary emboliDose chemotherapyRecurrent melanomaSerious complications
1996
Reconstructive Surgery in Melanoma Patients
Ariyan S. Reconstructive Surgery in Melanoma Patients. Surgical Oncology Clinics Of North America 1996, 5: 785-808. PMID: 8899945, DOI: 10.1016/s1055-3207(18)30353-3.ChaptersConceptsSurgical excisionFull-thickness skin graftingWide surgical excisionCost of hospitalizationSplit-thickness skinDepth of invasionEarly ambulationLocal recurrenceSurgical treatmentMelanoma patientsWide excisionWide resectionTumor thicknessCosmetic resultsPrimary closureFear of difficultySkin graftingMalignant melanomaReconstructive surgeryAnatomic sitesPrimary siteFurther experienceLocal flapsMethod of reconstructionExcision
1995
Multiple Primary Melanomas
Ariyan S, Poo W, Bolognia J, Buzaid A, Ariyan T, Ariyan S. Multiple Primary Melanomas. Plastic & Reconstructive Surgery 1995, 96: 1384-1389. PMID: 7480238, DOI: 10.1097/00006534-199511000-00023.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overFemaleHumansMaleMelanomaMiddle AgedNeoplasms, Second PrimaryPrognosisSkin NeoplasmsConceptsSecond primary melanomaPrimary melanomaPrimary cutaneous melanomaMultiple primary melanomasIncidence of melanomaYale Melanoma UnitFirst malignancySubsequent melanomaFirst diagnosisPoor prognosisCutaneous melanomaMelanoma UnitPatient prognosisMultiple melanomasSubsequent lesionsPatientsInitial melanomaMelanomaPrognosisFirst yearSecond yearReportYearsMalignancyStatistics Report
1989
Cutaneous Angiosarcoma of the Face and Scalp
Barttelbort S, Stahl R, Ariyan S. Cutaneous Angiosarcoma of the Face and Scalp. Plastic & Reconstructive Surgery 1989, 84: 55-59. PMID: 2734404, DOI: 10.1097/00006534-198907000-00011.Peer-Reviewed Original ResearchConceptsCutaneous angiosarcomaSurgical resectionIntraoperative frozen section analysisComplete surgical resectionFrozen section analysisHigh false-negative rateStaging biopsiesPostoperative radiationAggressive neoplasmClinical manifestationsFull courseFalse negative rateAngiosarcomaResectionNeoplasmsScalpTrue extentSection analysisPatientsBiopsyMisdiagnosis
1986
Single-Stage Repair of Complex Scalp and Cranial Defects with the Free Radial Forearm Flap
Chicarilli Z, Ariyan S, Cuono C. Single-Stage Repair of Complex Scalp and Cranial Defects with the Free Radial Forearm Flap. Plastic & Reconstructive Surgery 1986, 77: 577-585. PMID: 3952213, DOI: 10.1097/00006534-198604000-00010.Peer-Reviewed Original Research
1985
Versatility and Safety of Flap Coverage for Wide Excision of Cutaneous Melanomas
Cuono C, Ariyan S. Versatility and Safety of Flap Coverage for Wide Excision of Cutaneous Melanomas. Plastic & Reconstructive Surgery 1985, 76: 281-284. PMID: 3895262, DOI: 10.1097/00006534-198508000-00017.Peer-Reviewed Original ResearchMeSH KeywordsHumansMelanomaRetrospective StudiesSkin NeoplasmsSkin TransplantationSurgery, PlasticSurgical FlapsConceptsFlap repairWide excisionShorter hospital stayPostoperative flap necrosisIntransit metastasesHospital stayEarly mobilizationLocal recurrenceConsecutive seriesCutaneous melanomaFlap coverageFlap necrosisPrimary melanomaRetrospective analysisSkin graftsRhomboid flapContour defectsRhombic flapMelanomaExcisionFlapMonthsRepairPatientsRecurrence
1984
Regional isolated perfusion of high risk melanoma of the extremities with imidazole carboxamide.
Ariyan S, Mitchell M, Kirkwood J. Regional isolated perfusion of high risk melanoma of the extremities with imidazole carboxamide. Journal Of The American College Of Surgeons 1984, 158: 238-42. PMID: 6701736.Peer-Reviewed Original ResearchConceptsRegional isolated perfusionIntransit metastasesIsolated perfusionSerum glutamic-oxalacetic transaminase levelFirst postoperative dayGlutamic oxalacetic transaminase levelHigh-risk melanomaTransaminase levelsPostoperative daySubcutaneous metastasesFourth patientNew lesionsFifth patientRisk melanomaImidazole carboxamidePatientsPerfused extremitySymptoms of toxicityValuable drugMetastasisExtremitiesMelanomaPerfusionMonthsDecarbazine
1982
Granulomatous lymphangitis. A complication of intralymphatic immunotherapy with methanol extraction residue of BCG (MER)
Kirkwood J, Ariyan S, Nordlund J, Forget B. Granulomatous lymphangitis. A complication of intralymphatic immunotherapy with methanol extraction residue of BCG (MER). Cancer 1982, 50: 1299-1303. PMID: 7104973, DOI: 10.1002/1097-0142(19821001)50:7<1299::aid-cncr2820500714>3.0.co;2-#.Peer-Reviewed Original ResearchConceptsBacille Calmette-GuerinMethanol extraction residueCalmette-GuerinThick primary melanomasDefinitive surgical excisionAdjuvant therapyIntralymphatic immunotherapyRegional metastasesRecurrent melanomaRegional nodalClinical presentationSurgical excisionAdjuvant agentLocal instillationIntralymphatic injectionsPrimary tumorPrimary melanomaAntitumor effectsGranulomatous lymphangitisExperimental animalsSubstantial riskComplicationsThick primariesImmunotherapyTherapy
1980
Melanoma: a multidisciplinary overview of current concepts and management.
Kirkwood J, Tonkonow B, Nordlund J, Ariyan S, Forget B, Lerner A. Melanoma: a multidisciplinary overview of current concepts and management. Connecticut Medicine 1980, 44: 21-6. PMID: 7353362.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements