2022
Integrative molecular and clinical profiling of acral melanoma links focal amplification of 22q11.21 to metastasis
Farshidfar F, Rhrissorrakrai K, Levovitz C, Peng C, Knight J, Bacchiocchi A, Su J, Yin M, Sznol M, Ariyan S, Clune J, Olino K, Parida L, Nikolaus J, Zhang M, Zhao S, Wang Y, Huang G, Wan M, Li X, Cao J, Yan Q, Chen X, Newman AM, Halaban R. Integrative molecular and clinical profiling of acral melanoma links focal amplification of 22q11.21 to metastasis. Nature Communications 2022, 13: 898. PMID: 35197475, PMCID: PMC8866401, DOI: 10.1038/s41467-022-28566-4.Peer-Reviewed Original ResearchConceptsAcral melanomaMelanoma subtypesClinical profilingCommon melanoma subtypeImmune checkpoint blockadeCheckpoint blockadeInferior survivalMelanoma cell linesKey molecular driversPoor prognosisTherapeutic targetAnchorage-independent growthImmunomodulatory genesNon-white individualsHotspot mutationsMolecular driversCandidate oncogeneMelanomaApoptotic cell deathLZTR1Focal amplificationTumor promoterCell linesMetastasisTumor suppressor
2001
Surgical Considerations in the Management of Malignant Melanoma of the Ear
Narayan D, Ariyan S. Surgical Considerations in the Management of Malignant Melanoma of the Ear. Plastic & Reconstructive Surgery 2001, 107: 20-24. PMID: 11176596, DOI: 10.1097/00006534-200101000-00004.Peer-Reviewed Original ResearchConceptsMalignant melanomaLocal recurrenceYale-New Haven HospitalUnknown primary sitePrimary malignant melanomaPalpable nodesDisseminated diseaseRadical resectionConsecutive patientsLocal excisionRegional recurrenceWorse prognosisTransit melanomaConservative excisionSurgical considerationsSkin graftsDifficult lesionsFasciocutaneous flapPatientsPrimary siteMelanomaCosmetic importanceRecurrenceExternal earLesions
2000
Surgical Management Of The Primary Melanoma
Narayan D, Ariyan S. Surgical Management Of The Primary Melanoma. Clinics In Plastic Surgery 2000, 27: 409-419. PMID: 10941561, DOI: 10.1016/s0094-1298(20)32736-x.Peer-Reviewed Original ResearchRegional Lymph Node Dissections In Malignant Melanoma
Lawton G, Ariyan S. Regional Lymph Node Dissections In Malignant Melanoma. Clinics In Plastic Surgery 2000, 27: 431-440. PMID: 10941563, DOI: 10.1016/s0094-1298(20)32738-3.Peer-Reviewed Original ResearchConceptsElective lymph node dissectionLymph node dissectionNode dissectionNegative nodesTherapeutic lymph node dissectionRegional lymph node dissectionSentinel lymph node dissectionClinical stage ITime of resectionPositive nodesRegional lymphadenectomySentinel lymphProphylactic excisionCutaneous melanomaPrimary tumorMalignant melanomaPrimary melanomaRegional nodesSurvival advantageStage IPatientsMetastatic cellsMelanomaDissectionClear benefitLymphatic Mapping And Sentinel Lymph Node Biopsies
Ali-Salaam P, Ariyan S. Lymphatic Mapping And Sentinel Lymph Node Biopsies. Clinics In Plastic Surgery 2000, 27: 421-429. PMID: 10941562, DOI: 10.1016/s0094-1298(20)32737-1.Peer-Reviewed Original ResearchThe Use Of Isolated Limb Perfusion To Manage Recurrent Malignant Melanoma
Ma D, Ariyan S. The Use Of Isolated Limb Perfusion To Manage Recurrent Malignant Melanoma. Clinics In Plastic Surgery 2000, 27: 441-450. PMID: 10941564, DOI: 10.1016/s0094-1298(20)32739-5.Peer-Reviewed Original ResearchConceptsRecurrent malignant melanomaMalignant melanomaLimb perfusionTumor necrosis factor alphaRecurrent metastatic diseaseIsolated limb perfusionNecrosis factor alphaList of drugsHyperthermic ILPRecurrent diseaseMetastatic diseaseTumor loadLimb functionClinical trialsSurgical techniqueFactor alphaWound hygieneChemotherapeutic agentsMelanomaPerfusionDiseaseExtremitiesTreatmentHyperthermicTrials
1999
Follow‐up recommendations for patients with American Joint Committee on Cancer Stages I–III malignant melanoma
Poo‐Hwu W, Ariyan S, Lamb L, Papac R, Zelterman D, Hu G, Brown J, Fischer D, Bolognia J, Buzaid A. Follow‐up recommendations for patients with American Joint Committee on Cancer Stages I–III malignant melanoma. Cancer 1999, 86: 2252-2258. PMID: 10590365, DOI: 10.1002/(sici)1097-0142(19991201)86:11<2252::aid-cncr12>3.0.co;2-q.Peer-Reviewed Original ResearchConceptsCancer stage IAmerican Joint CommitteePatient education programStage IYale Melanoma UnitSurveillance scheduleSymptomatic recurrenceMelanoma UnitSurveillance examinationsJoint CommitteeOverall survival rateStage of diseaseDetection of recurrenceAsymptomatic recurrenceAsymptomatic patientsDistant recurrenceLocoregional recurrenceHazard ratioDisease recurrenceInitial visitMore recurrencesMost recurrencesLate recurrenceMelanoma patientsRecurrence group
1998
Safety and efficacy of isolated perfusion of extremities for recurrent tumor in elderly patients
Ariyan S, Poo W. Safety and efficacy of isolated perfusion of extremities for recurrent tumor in elderly patients. Surgery 1998, 123: 335-343. PMID: 9526527, DOI: 10.1016/s0039-6060(98)70188-6.Peer-Reviewed Original ResearchConceptsElderly patientsYounger patientsIsolated perfusionMeaningful disease controlRegional isolated perfusionEvidence of diseaseHigh-dose chemotherapySeries of patientsIsolated limb perfusionMajor surgical proceduresNumber of patientsDisease-free controlsYears of ageSalvage of limbsSignificant palliationThird perfusionAggressive treatmentDose chemotherapyOlder patientsRecurrent diseaseSurvival benefitTransit diseaseSerious complicationsRecurrent tumorsLimb perfusion
1997
Regional Isolated Perfusion of Extremities for Melanoma: A 20-Year Experience with Drugs Other than L-Phenylalanine Mustard
Ariyan S, Poo W, Bolognia J. Regional Isolated Perfusion of Extremities for Melanoma: A 20-Year Experience with Drugs Other than L-Phenylalanine Mustard. Plastic & Reconstructive Surgery 1997, 99: 1023-1029. PMID: 9091898, DOI: 10.1097/00006534-199704000-00016.Peer-Reviewed Original ResearchConceptsL-phenylalanine mustardRegional isolated perfusionIsolated limb perfusionIsolated perfusionLimb perfusionUpper extremityLower extremitiesTherapeutic isolated limb perfusionNonfatal pulmonary embolusRegional treatment modalityEvidence of diseaseHigh-dose chemotherapyHigh-risk melanomaNumber of patientsDifficult management problemDisease-free controlsTechnique of perfusionLimb recurrenceMeaningful palliationRepeat perfusionsAggressive treatmentPulmonary emboliDose chemotherapyRecurrent melanomaSerious complications
1996
Reconstructive Surgery in Melanoma Patients
Ariyan S. Reconstructive Surgery in Melanoma Patients. Surgical Oncology Clinics Of North America 1996, 5: 785-808. PMID: 8899945, DOI: 10.1016/s1055-3207(18)30353-3.ChaptersConceptsSurgical excisionFull-thickness skin graftingWide surgical excisionCost of hospitalizationSplit-thickness skinDepth of invasionEarly ambulationLocal recurrenceSurgical treatmentMelanoma patientsWide excisionWide resectionTumor thicknessCosmetic resultsPrimary closureFear of difficultySkin graftingMalignant melanomaReconstructive surgeryAnatomic sitesPrimary siteFurther experienceLocal flapsMethod of reconstructionExcisionProlonged Survival in Patients with Advanced Melanoma Treated with Neoadjuvant Chemotherapy Followed by Resection
Sasson H, Poo W, Bakas M, Ariyan S. Prolonged Survival in Patients with Advanced Melanoma Treated with Neoadjuvant Chemotherapy Followed by Resection. Annals Of Plastic Surgery 1996, 37: 286-292. PMID: 8883727, DOI: 10.1097/00000637-199609000-00009.Peer-Reviewed Original ResearchConceptsStart of chemotherapySite of metastasisSurgical resectionPerformance statusResidual metastasesNeoadjuvant chemotherapyCombination chemotherapyMetastatic melanomaRetrospective analysisCompletion of chemotherapyCycles of chemotherapyConcomitant medical problemsDistant lymph nodesInitiation of therapySimilar clinical characteristicsTreatment of choiceNew combination regimensSignificant survival advantageDuration of survivalHigh response rateStable diseaseRecurrent diseaseClinical characteristicsMedian durationPartial response
1995
Multiple Primary Melanomas
Ariyan S, Poo W, Bolognia J, Buzaid A, Ariyan T, Ariyan S. Multiple Primary Melanomas. Plastic & Reconstructive Surgery 1995, 96: 1384-1389. PMID: 7480238, DOI: 10.1097/00006534-199511000-00023.Peer-Reviewed Original ResearchConceptsSecond primary melanomaPrimary melanomaPrimary cutaneous melanomaMultiple primary melanomasIncidence of melanomaYale Melanoma UnitFirst malignancySubsequent melanomaFirst diagnosisPoor prognosisCutaneous melanomaMelanoma UnitPatient prognosisMultiple melanomasSubsequent lesionsPatientsInitial melanomaMelanomaPrognosisFirst yearSecond yearReportYearsMalignancyStatistics Report
1985
Versatility and Safety of Flap Coverage for Wide Excision of Cutaneous Melanomas
Cuono C, Ariyan S. Versatility and Safety of Flap Coverage for Wide Excision of Cutaneous Melanomas. Plastic & Reconstructive Surgery 1985, 76: 281-284. PMID: 3895262, DOI: 10.1097/00006534-198508000-00017.Peer-Reviewed Original ResearchConceptsFlap repairWide excisionShorter hospital stayPostoperative flap necrosisIntransit metastasesHospital stayEarly mobilizationLocal recurrenceConsecutive seriesCutaneous melanomaFlap coverageFlap necrosisPrimary melanomaRetrospective analysisSkin graftsRhomboid flapContour defectsRhombic flapMelanomaExcisionFlapMonthsRepairPatientsRecurrence
1984
Regional isolated perfusion of high risk melanoma of the extremities with imidazole carboxamide.
Ariyan S, Mitchell M, Kirkwood J. Regional isolated perfusion of high risk melanoma of the extremities with imidazole carboxamide. Journal Of The American College Of Surgeons 1984, 158: 238-42. PMID: 6701736.Peer-Reviewed Original ResearchConceptsRegional isolated perfusionIntransit metastasesIsolated perfusionSerum glutamic-oxalacetic transaminase levelFirst postoperative dayGlutamic oxalacetic transaminase levelHigh-risk melanomaTransaminase levelsPostoperative daySubcutaneous metastasesFourth patientNew lesionsFifth patientRisk melanomaImidazole carboxamidePatientsPerfused extremitySymptoms of toxicityValuable drugMetastasisExtremitiesMelanomaPerfusionMonthsDecarbazine
1983
Tomographic Gallium-67 Citrate Scanning Useful New Surveillance for Metastatic Melanoma
KIRKWOOD J, MYERS J, VLOCK D, NEUMANN R, ARIYAN S, GOTTSCHALK A, HOFFER P. Tomographic Gallium-67 Citrate Scanning Useful New Surveillance for Metastatic Melanoma. Annals Of Surgery 1983, 198: 102-107. PMID: 6859984, PMCID: PMC1352941, DOI: 10.1097/00000658-198307000-00020.Peer-Reviewed Original ResearchConceptsLymph nodesMetastatic melanomaTomographic scanBone sitesEvident lymph nodesIndependent clinical evaluationProspective surveillance studyPeripheral lymph nodesSoft tissue sitesLymphatic sitesMediastinal sitesGallium scanGallium imagingPulmonary sitesClinical evaluationTomographic scanningAbdominal sitesGallium uptakeBrain sitesOsseous sitesSurveillance studyDiscordant findingsTissue sitesOverall sensitivityMelanoma
1982
Tomographic gallium-67 citrate scanning: useful new surveillance for metastatic melanoma.
Kirkwood J, Myers J, Vlock D, Neumann R, Ariyan S, Gottschalk A, Hoffer P. Tomographic gallium-67 citrate scanning: useful new surveillance for metastatic melanoma. Annals Of Internal Medicine 1982, 97: 694-9. PMID: 7137734, DOI: 10.7326/0003-4819-97-5-694.Peer-Reviewed Original ResearchConceptsLymph nodesMetastatic melanomaTomographic scanBone sitesEvident lymph nodesIndependent clinical evaluationProspective surveillance studyPeripheral lymph nodesSoft tissue sitesLymphatic sitesMediastinal sitesGallium scanGallium imagingPulmonary sitesClinical evaluationTomographic scanningAbdominal sitesGallium uptakeBrain sitesOsseous sitesSurveillance studyDiscordant findingsTissue sitesOverall sensitivityMelanomaGranulomatous lymphangitis. A complication of intralymphatic immunotherapy with methanol extraction residue of BCG (MER)
Kirkwood J, Ariyan S, Nordlund J, Forget B. Granulomatous lymphangitis. A complication of intralymphatic immunotherapy with methanol extraction residue of BCG (MER). Cancer 1982, 50: 1299-1303. PMID: 7104973, DOI: 10.1002/1097-0142(19821001)50:7<1299::aid-cncr2820500714>3.0.co;2-#.Peer-Reviewed Original ResearchConceptsBacille Calmette-GuerinMethanol extraction residueCalmette-GuerinThick primary melanomasDefinitive surgical excisionAdjuvant therapyIntralymphatic immunotherapyRegional metastasesRecurrent melanomaRegional nodalClinical presentationSurgical excisionAdjuvant agentLocal instillationIntralymphatic injectionsPrimary tumorPrimary melanomaAntitumor effectsGranulomatous lymphangitisExperimental animalsSubstantial riskComplicationsThick primariesImmunotherapyTherapyIntralymphatic and regional surgical adjuvant immunotherapy in high-risk melanoma of the extremities.
Ariyan S, Kirkwood J, Mitchell M, Nordlund J, Lerner A, Papac R. Intralymphatic and regional surgical adjuvant immunotherapy in high-risk melanoma of the extremities. Surgery 1982, 92: 459-63. PMID: 7112396.Peer-Reviewed Original ResearchConceptsBacillus Calmette-GuerinSurgical adjuvant immunotherapyMER-BCGAdjuvant immunotherapyControl groupHigh-risk malignant melanomaDisease-free survivalHigh-risk melanomaIntraoperative infiltrationImmunotherapy groupIntradermal vaccinationIntralymphatic immunotherapyRegional lymphadenectomyConsecutive patientsSurgical excisionCalmette-GuerinMalignant melanomaPatientsImmunotherapyMethanol-extractable residueLymphadenectomyRecurrenceMelanomaExtremitiesSame interval
1980
Functional Radical Neck Dissection
Ariyan S, Ariyan S. Functional Radical Neck Dissection. Plastic & Reconstructive Surgery 1980, 65: 768-776. PMID: 7384278, DOI: 10.1097/00006534-198006000-00009.Peer-Reviewed Original ResearchConceptsRadical neck dissectionSpinal accessory nerveNeck dissectionAccessory nerveJugular veinClassical radical neck dissectionSquamous cell carcinomaNeck structuresOperative timeSternocleidomastoid muscleCell carcinomaCosmetic resultsNeck woundsSmall seriesPatientsDissectionMuscleNerveVeinSternal endComplicationsCarcinomaInjuryComplete removalNeckMelanoma: a multidisciplinary overview of current concepts and management.
Kirkwood J, Tonkonow B, Nordlund J, Ariyan S, Forget B, Lerner A. Melanoma: a multidisciplinary overview of current concepts and management. Connecticut Medicine 1980, 44: 21-6. PMID: 7353362.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements