2024
Immunotherapy utilization in stage IIIA melanoma: less may be more
Frey A, Kerekes D, Khan S, Tran T, Kluger H, Clune J, Ariyan S, Sznol M, Ishizuka J, Olino K. Immunotherapy utilization in stage IIIA melanoma: less may be more. Frontiers In Oncology 2024, 14: 1336441. PMID: 38380358, PMCID: PMC10876869, DOI: 10.3389/fonc.2024.1336441.Peer-Reviewed Original ResearchStage IIIA melanomaHigh-volume centersRisk-adjusted survivalLow-volume centersImmunotherapy utilizationAdjuvant immunotherapyStage IIIATreatment of stage III melanomaAcademic centersMultivariable Cox proportional hazards regressionStage III melanomaNational Cancer DatabaseStage III diseaseFactors associated with receiptCox proportional hazards regressionCompare patient outcomesProportional hazards regressionIII melanomaImmunotherapy receiptReceiving immunotherapyIII diseaseImmunotherapy agentsOverall survivalSurvival benefitAdjuvant treatment
2023
Case report: Metastatic Merkel cell carcinoma presenting seven years after loco-regional disease resection of primary tumor with interval in-transit and nodal metastases
Rusheen J, Clune J, Ariyan S, Baumann R, Kluger H, Olino K, Weiss S. Case report: Metastatic Merkel cell carcinoma presenting seven years after loco-regional disease resection of primary tumor with interval in-transit and nodal metastases. Frontiers In Oncology 2023, 13: 1217816. PMID: 37476373, PMCID: PMC10354444, DOI: 10.3389/fonc.2023.1217816.Peer-Reviewed Case Reports and Technical NotesMerkel cell carcinomaDuration of surveillanceLate recurrenceCell carcinomaMetastatic Merkel cell carcinomaPrimary Merkel cell carcinomaMetastases 15 monthsSuch late recurrencesPredictors of recurrenceNodal recurrenceDefinitive therapyFirst recurrenceDisease resectionNodal metastasisPhysical examinationRare tumorPrimary diagnosisPrimary tumorRisk factorsHigh riskNational guidelinesRecurrenceOptimal durationPatientsCarcinomaThe role of imaging and sentinel lymph node biopsy in patients with T3b-T4b melanoma with clinically negative disease
Papageorge M, Maina R, King A, Lee V, Baumann R, Pucar D, Ariyan S, Khan S, Weiss S, Clune J, Olino K. The role of imaging and sentinel lymph node biopsy in patients with T3b-T4b melanoma with clinically negative disease. Frontiers In Oncology 2023, 13: 1143354. PMID: 37223678, PMCID: PMC10200883, DOI: 10.3389/fonc.2023.1143354.Peer-Reviewed Original ResearchPre-operative imagingCross-sectional imagingFree survivalLow-risk melanomaHigh-risk melanomaHigh-risk diseaseKaplan-Meier methodRecurrence-free survivalSentinel node biopsyWide local excisionManagement of patientsLog-rank testRole of imagingPropensity-score matchingIncidental cancerT4b diseaseMetastatic diseaseNodal diseaseNode biopsyPerioperative periodMedian ageNegative diseaseSentinel lymphLocal excisionNodular melanomaMalignant Melanoma in Older Adults: Different Patient or Different Disease?
Sasson D, Smetona J, Parsaei Y, Papageorge M, Ariyan S, Olino K, Clune J. Malignant Melanoma in Older Adults: Different Patient or Different Disease? Cureus 2023, 15: e34742. PMID: 36909026, PMCID: PMC9998075, DOI: 10.7759/cureus.34742.Peer-Reviewed Original ResearchMelanoma-specific survivalRecurrence-free survivalOlder patientsT2 tumorsNodal positivityMetastatic progressionOlder adultsConclusion Older adultsLog-rank testingKaplan-Meier analysisT4 tumorsYounger patientsT1 tumorsBreslow thicknessClinical outcomesTumor characteristicsTumor thicknessSingle institutionClinical behaviorMalignant melanomaLower incidenceHigh incidencePatientsConsecutive sampleAge groupsPredictive accuracy of elevated mitotic rate on lymph node positivity and recurrence in thin melanomas
Ly C, Blaha O, Wei W, Galan A, Kluger H, Ariyan S, Olino K, Clune J. Predictive accuracy of elevated mitotic rate on lymph node positivity and recurrence in thin melanomas. Frontiers In Oncology 2023, 12: 1077226. PMID: 36686728, PMCID: PMC9853390, DOI: 10.3389/fonc.2022.1077226.Peer-Reviewed Original ResearchMelanoma-specific mortalityElevated mitotic rateLymph node positivityMitoses/Mitotic rateT2 tumorsNode positivityThin melanomasSentinel lymph node positivityImportant prognostic factorSingle academic centerPrimary cutaneous melanomaLow mitotic ratePositive SLNNon-ulcerated lesionsSLN biopsyT4 tumorsPatient demographicsPrognostic factorsSLN positivityRetrospective reviewTumor characteristicsBreslow thicknessCutaneous melanomaT category
2022
Author Correction: Integrative molecular and clinical profiling of acral melanoma links focal amplification of 22q11.21 to metastasis
Farshidfar F, Rhrissorrakrai K, Levovitz C, Peng C, Knight J, Bacchiocchi A, Su J, Yin M, Sznol M, Ariyan S, Clune J, Olino K, Parida L, Nikolaus J, Zhang M, Zhao S, Wang Y, Huang G, Wan M, Li X, Cao J, Yan Q, Chen X, Newman AM, Halaban R. Author Correction: Integrative molecular and clinical profiling of acral melanoma links focal amplification of 22q11.21 to metastasis. Nature Communications 2022, 13: 2704. PMID: 35538087, PMCID: PMC9090916, DOI: 10.1038/s41467-022-30446-w.Peer-Reviewed Original ResearchIntegrative molecular and clinical profiling of acral melanoma links focal amplification of 22q11.21 to metastasis
Farshidfar F, Rhrissorrakrai K, Levovitz C, Peng C, Knight J, Bacchiocchi A, Su J, Yin M, Sznol M, Ariyan S, Clune J, Olino K, Parida L, Nikolaus J, Zhang M, Zhao S, Wang Y, Huang G, Wan M, Li X, Cao J, Yan Q, Chen X, Newman AM, Halaban R. Integrative molecular and clinical profiling of acral melanoma links focal amplification of 22q11.21 to metastasis. Nature Communications 2022, 13: 898. PMID: 35197475, PMCID: PMC8866401, DOI: 10.1038/s41467-022-28566-4.Peer-Reviewed Original ResearchConceptsAcral melanomaMelanoma subtypesClinical profilingCommon melanoma subtypeImmune checkpoint blockadeCheckpoint blockadeInferior survivalMelanoma cell linesKey molecular driversPoor prognosisTherapeutic targetAnchorage-independent growthImmunomodulatory genesNon-white individualsHotspot mutationsMolecular driversCandidate oncogeneMelanomaApoptotic cell deathLZTR1Focal amplificationTumor promoterCell linesMetastasisTumor suppressor
2017
Distinct dominant T-cell receptors with a tissue resident memory phenotype in individual melanoma metastases.
Dhodapkar K, Boddupalli C, Bar N, Kadaveru K, Krauthammer M, Pornputtapong N, Mai Z, Ariyan S, Narayan D, Kluger H, Deng Y, Verma R, Das R, Bacchiocchi A, Halaban R, Sznol M, Dhodapkar M. Distinct dominant T-cell receptors with a tissue resident memory phenotype in individual melanoma metastases. Journal Of Clinical Oncology 2017, 35: 3-3. DOI: 10.1200/jco.2017.35.7_suppl.3.Peer-Reviewed Original ResearchInhibitory immune checkpointsTissue-resident memory TT cellsIndividual metastasesMelanoma metastasesDominant T-cell receptorReduced T cell infiltrationTissue-resident memory phenotypeEffective anti-tumor immunityT-cell receptor sequencingTumor cellsExome sequencingResident memory phenotypeResident memory TT RM cellsAnti-tumor immunityT cell infiltrationCell receptor sequencingT cell subsetsAntibody-mediated blockadeT-cell contentVascular endothelial growth factorSingle-cell mass cytometryCell mass cytometryEndothelial growth factor
2016
Fibula Osteocutaneous Flap for Mandibular Reconstruction
Ariyan S. Fibula Osteocutaneous Flap for Mandibular Reconstruction. 2016, 369-372. DOI: 10.1007/978-3-319-40631-2_88.Peer-Reviewed Original ResearchPrevious radiation therapyHead neck cancerMicrovascular free flapsFibula osteocutaneous flapHead-neck areaSurgical treatmentBilateral resectionNeck cancerIntraoral bacteriaRadiation therapyOsteocutaneous flapFree flapNeck areaResectionIntraoral reconstructionDurable techniquePoor hygieneMandibular reconstructionSoft tissueMandibleTissue/Contralateral angleFlapBoneTherapyPectoralis Major Flap for Head and Neck Reconstruction
Ariyan S. Pectoralis Major Flap for Head and Neck Reconstruction. 2016, 365-368. DOI: 10.1007/978-3-319-40631-2_87.Peer-Reviewed Original ResearchMyocutaneous flapPectoralis major myocutaneous flapPrevious radiation therapyFree flap reconstructionPectoralis major flapMajor myocutaneous flapHead-neck areaFlap reconstructionMajor flapIntraoral bacteriaRadiation therapyNeck reconstructionNeck areaSurgical preparationPectoralis majorVascular anatomyPoor hygieneStage reconstructionFlapSurgical skillsReliable techniqueResectionTherapyCancerInterlesional diversity of T cell receptors in melanoma with immune checkpoints enriched in tissue-resident memory T cells
Boddupalli CS, Bar N, Kadaveru K, Krauthammer M, Pornputtapong N, Mai Z, Ariyan S, Narayan D, Kluger H, Deng Y, Verma R, Das R, Bacchiocchi A, Halaban R, Sznol M, Dhodapkar MV, Dhodapkar KM. Interlesional diversity of T cell receptors in melanoma with immune checkpoints enriched in tissue-resident memory T cells. JCI Insight 2016, 1: e88955. PMID: 28018970, PMCID: PMC5161225, DOI: 10.1172/jci.insight.88955.Peer-Reviewed Original ResearchTumor-infiltrating lymphocytesMemory T cellsTissue-resident memory T cellsT cell receptorImmune checkpointsT cellsIndividual metastasesSubset of TILsExpression of ICsCell receptorTumor cellsLess IL-2Blood T cellsExpression of VEGFTIL infiltrationDurable responsesAdvanced melanomaImmune therapyNeoantigen loadIL-2Immune cellsNonlymphoid tissuesSame patientMyeloid cellsMetastasisCorrelation of body mass index with female survival benefit among a single-institution cohort of cutaneous melanomas >1 mm thick following wide-local excision and sentinel lymph node biopsy.
Jackson L, Bulloch K, Narayan D, Ariyan S, Gould Rothberg BE. Correlation of body mass index with female survival benefit among a single-institution cohort of cutaneous melanomas >1 mm thick following wide-local excision and sentinel lymph node biopsy. Journal Of Clinical Oncology 2016, 34: 172-172. DOI: 10.1200/jco.2016.34.3_suppl.172.Peer-Reviewed Original ResearchBody mass indexDisease-free survivalWide local excisionCutaneous melanomaSurvival benefitSentinel lymphMass indexNormal-weight menNormal-weight womenSingle-institution cohortCox proportional hazardsNon-therapeutic interventionsFree survivalSLN statusWeight womenClinicopathologic factorsConsecutive patientsLocal excisionMultivariable analysisWeight menLifestyle factorsActive surveillanceSimilar survivalSurvival advantageMitotic count
2012
492. Skin Flap Closure in Desmoplastic Melanoma - a 12-year Experience
Walker M, Broer P, Mody P, Patel A, Lazova R, Narayan D, Ariyan S. 492. Skin Flap Closure in Desmoplastic Melanoma - a 12-year Experience. European Journal Of Surgical Oncology 2012, 38: 873. DOI: 10.1016/j.ejso.2012.06.437.Peer-Reviewed Original Research119. Desmoplastic melanoma – A 12-year experience with sentinel lymph node biopsy
Walker M, Broer P, Goldberg C, Buonocore S, Braddock D, Lazova R, Narayan D, Ariyan S. 119. Desmoplastic melanoma – A 12-year experience with sentinel lymph node biopsy. European Journal Of Surgical Oncology 2012, 38: 771. DOI: 10.1016/j.ejso.2012.06.119.Peer-Reviewed Original Research
2009
Reconstruction in RDEB Patients
Buonocore S, Ariyan S. Reconstruction in RDEB Patients. Annals Of Plastic Surgery 2009, 63: 693. DOI: 10.1097/sap.0b013e3181c5216b.Peer-Reviewed Original Research
2006
Discussion
Ariyan S. Discussion. Plastic & Reconstructive Surgery 2006, 118: 1150. DOI: 10.1097/01.prs.0000221116.89270.04.Commentaries, Editorials and Letters
2005
Discussion
Ariyan S. Discussion. Plastic & Reconstructive Surgery 2005, 115: 1353-1354. DOI: 10.1097/01.prs.0000156973.50802.0b.Commentaries, Editorials and Letters
2004
Expression profiling reveals novel pathways in the transformation of Melanocytes to Melanomas.
Hoek K, Rimm D, Williams K, Zhao H, Ariyan S, Lin A, Kluger H, Berger A, Cheng E, Trombetta E, Wu T, Halaban R, Niinobe M, Yoshikawa K, Hannigan G. Expression profiling reveals novel pathways in the transformation of Melanocytes to Melanomas. Pigment Cell & Melanoma Research 2004, 17: 430-430. DOI: 10.1111/j.1600-0749.2004.00175_12.x.Peer-Reviewed Original Research
2002
Merkel Cell Carcinoma: Five Case Reports Using Sentinel Lymph Node Biopsy and a Review of 110 New Cases
Pan D, Narayan D, Ariyan S. Merkel Cell Carcinoma: Five Case Reports Using Sentinel Lymph Node Biopsy and a Review of 110 New Cases. Plastic & Reconstructive Surgery 2002, 110: 1259-1265. DOI: 10.1097/00006534-200210000-00007.Peer-Reviewed Original Research
2001
Surgical Considerations in the Management of Malignant Melanoma of the Ear
Narayan D, Ariyan S. Surgical Considerations in the Management of Malignant Melanoma of the Ear. Plastic & Reconstructive Surgery 2001, 107: 20-24. PMID: 11176596, DOI: 10.1097/00006534-200101000-00004.Peer-Reviewed Original ResearchConceptsMalignant melanomaLocal recurrenceYale-New Haven HospitalUnknown primary sitePrimary malignant melanomaPalpable nodesDisseminated diseaseRadical resectionConsecutive patientsLocal excisionRegional recurrenceWorse prognosisTransit melanomaConservative excisionSurgical considerationsSkin graftsDifficult lesionsFasciocutaneous flapPatientsPrimary siteMelanomaCosmetic importanceRecurrenceExternal earLesions