2013
Reconstruction of regulatory networks through temporal enrichment profiling and its application to H1N1 influenza viral infection
Zaslavsky E, Nudelman G, Marquez S, Hershberg U, Hartmann BM, Thakar J, Sealfon SC, Kleinstein SH. Reconstruction of regulatory networks through temporal enrichment profiling and its application to H1N1 influenza viral infection. BMC Bioinformatics 2013, 14: s1. PMID: 23734902, PMCID: PMC3633009, DOI: 10.1186/1471-2105-14-s6-s1.Peer-Reviewed Original ResearchConceptsRegulatory networksTranscription factorsExtensive genetic reprogrammingUnderlying transcriptional networksGene expression patternsAntiviral responseGene expression changesNovel antiviral factorTranscriptional cascadeTranscriptional networksDendritic cellsPromoter analysisRegulatory connectionsGenetic reprogrammingTranscriptional programsExpression patternsNetwork reconstruction methodsExpression changesCellular responsesExpression kineticsMonocyte-derived human dendritic cellsAntiviral stateHuman monocyte-derived dendritic cellsSuch virus infectionsImmune antagonists
2010
Lambda and alpha interferons inhibit hepatitis B virus replication through a common molecular mechanism but with different in vivo activities
Pagliaccetti NE, Chu EN, Bolen CR, Kleinstein SH, Robek MD. Lambda and alpha interferons inhibit hepatitis B virus replication through a common molecular mechanism but with different in vivo activities. Virology 2010, 401: 197-206. PMID: 20303135, PMCID: PMC2864496, DOI: 10.1016/j.virol.2010.02.022.Peer-Reviewed Original ResearchConceptsIFN-alpha/betaIFN-lambdaHepatitis B virus replicationB virus replicationType III interferonsRelated cytokines interleukinWeak antiviral activityHBV responseHBV replicationIL-22IL-6Molecular mechanismsCytokines interleukinAlpha interferonAntiviral immunityIII interferonsTransgenic miceAntiviral responseAntiviral mechanismAntiviral activityVirus replicationUnique receptorCommon molecular mechanismIFN-lambda2Vivo activityAntiviral Response Dictated by Choreographed Cascade of Transcription Factors
Zaslavsky E, Hershberg U, Seto J, Pham AM, Marquez S, Duke JL, Wetmur JG, tenOever BR, Sealfon SC, Kleinstein SH. Antiviral Response Dictated by Choreographed Cascade of Transcription Factors. The Journal Of Immunology 2010, 184: 2908-2917. PMID: 20164420, PMCID: PMC2856074, DOI: 10.4049/jimmunol.0903453.Peer-Reviewed Original ResearchMeSH KeywordsConserved SequenceDendritic CellsGene Expression Regulation, ViralGenes, OverlappingHumansMonocytesMultigene FamilyNewcastle disease virusOligonucleotide Array Sequence AnalysisPredictive Value of TestsPromoter Regions, GeneticReproducibility of ResultsTranscription FactorsUp-RegulationConceptsCell state transitionsRegulatory networksTranscription factorsGenetic programMost individual genesNovel transcription factorSpecific transcription factorsSingle regulatory networkAntiviral responseGene expression changesCurrent biological knowledgeActivation of RIGChoreographed cascadePromoter analysisIndividual genesGenetic regulatory networksMaster regulatorExpression changesBiological knowledgeExpression kineticsImmune evasion genesAntiviral roleImmune antagonistsHost immune systemNewcastle disease virus
2008
Interleukin-29 Functions Cooperatively with Interferon to Induce Antiviral Gene Expression and Inhibit Hepatitis C Virus Replication*
Pagliaccetti NE, Eduardo R, Kleinstein SH, Mu XJ, Bandi P, Robek MD. Interleukin-29 Functions Cooperatively with Interferon to Induce Antiviral Gene Expression and Inhibit Hepatitis C Virus Replication*. Journal Of Biological Chemistry 2008, 283: 30079-30089. PMID: 18757365, PMCID: PMC2662072, DOI: 10.1074/jbc.m804296200.Peer-Reviewed Original ResearchConceptsAntiviral gene expressionIFN-alpha/betaIL-29IFN-alphaVirus replicationIFN-gammaInhibits Hepatitis C Virus ReplicationCritical innate immune responseAntiviral activityHepatitis C virus replicationChronic viral infectionsC virus replicationGreater antiviral activityInnate immune responseIFN-gamma combinationHepatitis CGene expressionCellular antiviral responseCytokines interleukinHCV replicationImmune responseViral infectionIndividual cytokinesVesicular stomatitis virusAntiviral response