2011
Biomedical Model Fitting and Error Analysis
Costa KD, Kleinstein SH, Hershberg U. Biomedical Model Fitting and Error Analysis. Science Signaling 2011, 4: tr9. PMID: 21954296, PMCID: PMC3272496, DOI: 10.1126/scisignal.2001983.Peer-Reviewed Original ResearchConceptsMathematical modelAppropriate mathematical modelModel parametersError analysisFit parameter valuesLinearization schemeNonlinear modelGoodness of fitNonlinear dataModel fittingBest fitParameter valuesInverse modelingComputational methodsParticular applicationSuch constantsExperimental dataFittingBiomedical systemsProblemFitModelParametersConstantsSeries of measurements
2006
Nonuniform Sampling for Global Optimization of Kinetic Rate Constants in Biological Pathways
Kleinstein S, Bottino D, Georgieva A, Sarangapani R, Lett G. Nonuniform Sampling for Global Optimization of Kinetic Rate Constants in Biological Pathways. 2006, 1611-1616. DOI: 10.1109/wsc.2006.322934.Peer-Reviewed Original ResearchGlobal optimizationNon-optimal local minimaParameter estimation problemEvolutionary-type algorithmEstimation problemDifferential evolutionSlow convergenceNonuniform sampling methodLocal minimaOptimizationConvergenceEvolutionary strategyMisconvergencePowerful toolProblemPathway modelEstimationSampling methodAlgorithmRobustnessConstants