Nonuniform Sampling for Global Optimization of Kinetic Rate Constants in Biological Pathways
Kleinstein S, Bottino D, Georgieva A, Sarangapani R, Lett G. Nonuniform Sampling for Global Optimization of Kinetic Rate Constants in Biological Pathways. 2006, 1611-1616. DOI: 10.1109/wsc.2006.322934.Peer-Reviewed Original ResearchGlobal optimizationNon-optimal local minimaParameter estimation problemEvolutionary-type algorithmEstimation problemDifferential evolutionSlow convergenceNonuniform sampling methodLocal minimaOptimizationConvergenceEvolutionary strategyMisconvergencePowerful toolProblemPathway modelEstimationSampling methodAlgorithmRobustnessConstants