2014
DNA Demethylation By Activation-Induced Cytidine Deaminase in B Cell Lymphoma
Xi Y, Shivarov V, Yaari G, Kleinstein S, Strout M. DNA Demethylation By Activation-Induced Cytidine Deaminase in B Cell Lymphoma. Blood 2014, 124: 3549. DOI: 10.1182/blood.v124.21.3549.3549.Peer-Reviewed Original ResearchActivation-induced cytidine deaminaseDNA demethylationGene expressionDNA methylationMethylation sitesBisulfite sequencingBL2 cellsHumanHT-12 v4 Expression BeadChipPrimary transcriptional start sitesC-terminal deletion mutantsCpG sitesGenome-wide methylation profilingActive DNA demethylationMethylation statusRNA polymerase IISomatic cell differentiationCytidine deaminaseSingle-nucleotide resolutionTranscriptional start siteSubset of genesDNA repair pathwaysList of genesTarget gene expressionEarly cell developmentV4 Expression BeadChip
2012
Identification of Core DNA Elements That Target Somatic Hypermutation
Kohler KM, McDonald JJ, Duke JL, Arakawa H, Tan S, Kleinstein SH, Buerstedde JM, Schatz DG. Identification of Core DNA Elements That Target Somatic Hypermutation. The Journal Of Immunology 2012, 189: 5314-5326. PMID: 23087403, PMCID: PMC3664039, DOI: 10.4049/jimmunol.1202082.Peer-Reviewed Original ResearchMeSH Keywords3' Flanking RegionAnimalsB-LymphocytesCells, CulturedChickensChromatin ImmunoprecipitationCytidine DeaminaseDNAEnhancer Elements, GeneticGenes, ImmunoglobulinGenetic LociImmunoassayImmunoglobulin Variable RegionMutationPhosphorylationRNA Polymerase IISerineSomatic Hypermutation, ImmunoglobulinTranscription, GeneticConceptsActivation-induced deaminaseDNA elementsSomatic hypermutationChicken DT40 B cellsIg lociChromatin immunoprecipitation experimentsDT40 B cellsRNA polymerase IISystematic deletion analysisL chain lociNon-Ig genesCore DNA elementSerine 5Epigenetic marksPolymerase IITranscriptional elongationMutational machineryDeletion analysisReporter cassetteImmunoprecipitation experimentsDeoxycytosine residuesIg genesDNA damageChain locusLoci