2013
Reconstruction of regulatory networks through temporal enrichment profiling and its application to H1N1 influenza viral infection
Zaslavsky E, Nudelman G, Marquez S, Hershberg U, Hartmann BM, Thakar J, Sealfon SC, Kleinstein SH. Reconstruction of regulatory networks through temporal enrichment profiling and its application to H1N1 influenza viral infection. BMC Bioinformatics 2013, 14: s1. PMID: 23734902, PMCID: PMC3633009, DOI: 10.1186/1471-2105-14-s6-s1.Peer-Reviewed Original ResearchConceptsRegulatory networksTranscription factorsExtensive genetic reprogrammingUnderlying transcriptional networksGene expression patternsAntiviral responseGene expression changesNovel antiviral factorTranscriptional cascadeTranscriptional networksDendritic cellsPromoter analysisRegulatory connectionsGenetic reprogrammingTranscriptional programsExpression patternsNetwork reconstruction methodsExpression changesCellular responsesExpression kineticsMonocyte-derived human dendritic cellsAntiviral stateHuman monocyte-derived dendritic cellsSuch virus infectionsImmune antagonists
2010
Antiviral Response Dictated by Choreographed Cascade of Transcription Factors
Zaslavsky E, Hershberg U, Seto J, Pham AM, Marquez S, Duke JL, Wetmur JG, tenOever BR, Sealfon SC, Kleinstein SH. Antiviral Response Dictated by Choreographed Cascade of Transcription Factors. The Journal Of Immunology 2010, 184: 2908-2917. PMID: 20164420, PMCID: PMC2856074, DOI: 10.4049/jimmunol.0903453.Peer-Reviewed Original ResearchMeSH KeywordsConserved SequenceDendritic CellsGene Expression Regulation, ViralGenes, OverlappingHumansMonocytesMultigene FamilyNewcastle disease virusOligonucleotide Array Sequence AnalysisPredictive Value of TestsPromoter Regions, GeneticReproducibility of ResultsTranscription FactorsUp-RegulationConceptsCell state transitionsRegulatory networksTranscription factorsGenetic programMost individual genesNovel transcription factorSpecific transcription factorsSingle regulatory networkAntiviral responseGene expression changesCurrent biological knowledgeActivation of RIGChoreographed cascadePromoter analysisIndividual genesGenetic regulatory networksMaster regulatorExpression changesBiological knowledgeExpression kineticsImmune evasion genesAntiviral roleImmune antagonistsHost immune systemNewcastle disease virus