2024
Memory B cell subsets have divergent developmental origins that are coupled to distinct imprinted epigenetic states
Callahan D, Smita S, Joachim S, Hoehn K, Kleinstein S, Weisel F, Chikina M, Shlomchik M. Memory B cell subsets have divergent developmental origins that are coupled to distinct imprinted epigenetic states. Nature Immunology 2024, 25: 562-575. PMID: 38200277, DOI: 10.1038/s41590-023-01721-9.Peer-Reviewed Original ResearchGerminal center B cellsDistinct genomic featuresDP cellsDevelopmental originsEpigenetic stateFunctional diversityEpigenetic patternsTranscriptional profilingGenomic featuresDN cellsDistinct developmental historiesB cellsReporter miceFunctional responseCellsMemory B cellsChromatinB cell subsetsCell-dependent responsesMultiple approachesProgenyDiversityT cell-dependent responsesGerminal centersDevelopmental history
2011
Cell subset prediction for blood genomic studies
Bolen CR, Uduman M, Kleinstein SH. Cell subset prediction for blood genomic studies. BMC Bioinformatics 2011, 12: 258. PMID: 21702940, PMCID: PMC3213685, DOI: 10.1186/1471-2105-12-258.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear cellsTotal peripheral blood mononuclear cellsGene signatureSubset-specific genesBlood mononuclear cellsPatient blood samplesPersonalized treatment decisionsSpecific cell subsetsHCV patientsPBMC subsetsNK cellsStandard therapyCell subsetsMononuclear cellsT cellsTreatment decisionsTherapy responseBlood samplesB cellsMyeloid cellsCellular sourceTranscriptional profilingDisease mechanismsGene expression profilesCells