2013
A Pilot Study Of Sorafenib In Refractory Or Relapsed T-Cell Lymphoma Patients
Fraser J, Lansigan F, Seropian S, Barbarotta L, Foss F. A Pilot Study Of Sorafenib In Refractory Or Relapsed T-Cell Lymphoma Patients. Blood 2013, 122: 4356. DOI: 10.1182/blood.v122.21.4356.4356.Peer-Reviewed Original ResearchPeripheral T-cell lymphomaCutaneous T-cell lymphomaT-cell lymphomaRefractory T-cell lymphomaStarting doseStage IIBSkin toxicityPilot studyClinical activityRelapsed T-cell lymphomaAllogeneic stem cell transplantAngioimmunoblastic T-cell lymphomaT-cell lymphoma patientsPlatelet-derived growth factor receptor alphaProgression-free survivalStem cell transplantDuration of responseGrowth factor receptor alphaOff-label useT-cell NHLNumber of therapiesMulti-kinase inhibitorAdvisory CommitteeClinical CRStable disease
2010
A Phase 1 Trial of Vorinostat and Pegylated Liposomal Doxorubicin In Relapsed or Refractory Lymphoma.
Lansigan F, Seropian S, Cooper D, Potter V, Sowers N, Foss F. A Phase 1 Trial of Vorinostat and Pegylated Liposomal Doxorubicin In Relapsed or Refractory Lymphoma. Blood 2010, 116: 2816. DOI: 10.1182/blood.v116.21.2816.2816.Peer-Reviewed Original ResearchDose level 3Stem cell transplantStable diseaseHL patientsHodgkin's lymphomaPartial responseRefractory lymphomaCell transplantCardiac toxicityDisease progressionLiposomal doxorubicinLymphoplasmacytic lymphomaGrade 3Prior treatmentAST/ALT elevationAutologous stem cell transplantMedian age 69 yearsAllogeneic stem cell transplantPeripheral T-cell lymphomaTherapy warrants further investigationDisease controlLarge B-cell lymphomaDose level 1Dose level 2Doses of vorinostat