2015
Outcomes of acute leukemia patients transplanted with naive T cell–depleted stem cell grafts
Bleakley M, Heimfeld S, Loeb KR, Jones LA, Chaney C, Seropian S, Gooley TA, Sommermeyer F, Riddell SR, Shlomchik WD. Outcomes of acute leukemia patients transplanted with naive T cell–depleted stem cell grafts. Journal Of Clinical Investigation 2015, 125: 2677-2689. PMID: 26053664, PMCID: PMC4563691, DOI: 10.1172/jci81229.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdolescentAdrenal Cortex HormonesAdultAnimalsChronic DiseaseDisease-Free SurvivalFemaleGraft vs Host DiseaseHematopoietic Stem Cell TransplantationHistocompatibility TestingHumansKaplan-Meier EstimateLeukemiaLymphocyte DepletionMaleMiceMiddle AgedMyelodysplastic SyndromesTissue DonorsT-Lymphocyte SubsetsTransplantation ConditioningTransplantation, HomologousYoung AdultConceptsHematopoietic stem cell transplantationStem cell graftsChronic GVHDT cellsCell graftsT-cell-depleted stem cell graftsPeripheral blood stem cell graftsAllogeneic hematopoietic stem cell transplantationBlood stem cell graftsFunctional T-cell memoryT-cell-replete graftsPathogen-specific T cellsSingle-arm clinical trialT-cell recoveryVirus-specific immunityStem cell allograftsTotal body irradiationMemory T cellsStem cell transplantationT cell memoryAcute leukemia patientsHigh-risk leukemiaNaive T cellsAcute GVHDSevere GVHD
2005
Lichen sclerosus and eosinophilic fasciitis as manifestations of chronic graft-versus-host disease: Expanding the sclerodermoid spectrum
Schaffer JV, McNiff JM, Seropian S, Cooper DL, Bolognia JL. Lichen sclerosus and eosinophilic fasciitis as manifestations of chronic graft-versus-host disease: Expanding the sclerodermoid spectrum. Journal Of The American Academy Of Dermatology 2005, 53: 591-601. PMID: 16198778, DOI: 10.1016/j.jaad.2005.06.015.Peer-Reviewed Original ResearchConceptsEosinophilic fasciitisLichen sclerosusSclerodermoid GVHDHost diseaseBandlike lymphocytic infiltrateChronic cutaneous graftChronic cutaneous GVHDMajor clinical categoriesPresentations of GVHDClassic histologic featuresChronic graftChronic GVHDCutaneous GVHDSclerodermoid formAcute onsetCutaneous graftFollicular pluggingInitial presentationLymphocytic infiltrateCase seriesEpidermal atrophyHistologic featuresLS lesionsGVHDClinical categories
2000
Chronic graft‐versus‐host disease of the liver: Presentation as an acute hepatitis
Strasser S, Shulman H, Flowers M, Reddy R, Margolis D, Prumbaum M, Seropian S, McDonald G. Chronic graft‐versus‐host disease of the liver: Presentation as an acute hepatitis. Hepatology 2000, 32: 1265-1271. PMID: 11093733, DOI: 10.1053/jhep.2000.20067.Peer-Reviewed Original ResearchConceptsSmall bile ductsBile ductChronic graftHost diseaseAcute hepatitisLiver dysfunctionAlanine transaminaseHigh-dose immunosuppressive therapyProgressive bile duct destructionAllogeneic hematopoietic cell transplantationBile duct destructionChronic liver GVHDHigh-dose immunosuppressionAcute viral hepatitisHematopoietic cell transplantationSerum alanine transaminaseCholestatic pictureChronic GVHDEye involvementImmunosuppressive medicationsLiver GVHDLobular hepatitisMedian bilirubinNecroinflammatory fociDuct destruction