SMAC Mimetic Birinapant plus Radiation Eradicates Human Head and Neck Cancers with Genomic Amplifications of Cell Death Genes FADD and BIRC2
Eytan D, Snow G, Carlson S, Derakhshan A, Saleh A, Schiltz S, Cheng H, Mohan S, Cornelius S, Coupar J, Sowers A, Hernandez L, Mitchell J, Annunziata C, Chen Z, Van Waes C. SMAC Mimetic Birinapant plus Radiation Eradicates Human Head and Neck Cancers with Genomic Amplifications of Cell Death Genes FADD and BIRC2. Cancer Research 2016, 76: 5442-5454. PMID: 27469115, PMCID: PMC5026594, DOI: 10.1158/0008-5472.can-15-3317.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntineoplastic AgentsBlotting, WesternCarcinoma, Squamous CellCell Line, TumorChemoradiotherapyDipeptidesFas-Associated Death Domain ProteinFemaleGene AmplificationGene Knockdown TechniquesHead and Neck NeoplasmsHumansImmunohistochemistryIndolesInhibitor of Apoptosis ProteinsMiceMice, Inbred BALB CMice, SCIDReal-Time Polymerase Chain ReactionSquamous Cell Carcinoma of Head and NeckTNF-Related Apoptosis-Inducing LigandTumor Necrosis Factor-alphaUbiquitin-Protein LigasesXenograft Model Antitumor AssaysConceptsSmac mimeticsCell deathNovel Smac mimeticsCaspase-dependent apoptosisExpression of FADDFrequent genomic amplificationCell cycle arrestBaculovirus inhibitorG2-M cell cycle arrestApoptosis repeatCancer Genome AtlasDeath domainIAP inhibitorsFunctional importanceSiRNA knockdownDNA fragmentationHNSCC cell linesFADDBirinapantGenomic amplificationGene transferGenome AtlasProtein markersComparison of tumorGenomic alterations